[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100636101":3},{"organization":4,"armGroups":7,"interventions":27,"overallOfficials":33,"centralContacts":34,"locations":43,"responsibleParty":61,"collaborators":33,"id":65,"slug":66,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":71,"eligibilityCriteria":72,"healthyVolunteers":67,"sex":73,"minAge":33,"maxAge":33,"enrollmentInfo":74,"targetDuration":33,"studyType":77,"phases":78,"briefSummary":80,"conditions":81,"keywords":84,"overallStatus":86,"whyStopped":33,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"University of Pennsylvania","OTHER",[8,14,19,23],{"label":9,"type":10,"description":11,"interventionNames":12},"Index: Standard titration table","ACTIVE_COMPARATOR","Patients are treated with ECT using titration table 1 (alternating increases in frequency and duration)",[13],"Procedure: Electroconvulsive Therapy",{"label":15,"type":16,"description":17,"interventionNames":18},"Index: Frequency-then-duration","EXPERIMENTAL","ECT provided using Table 2, frequency uptitration followed by duration uptitration",[13],{"label":20,"type":16,"description":21,"interventionNames":22},"Index: Duration then Frequency","ECT provided using Table 3, duration titration then frequency titration",[13],{"label":24,"type":6,"description":25,"interventionNames":26},"Maintenance","Internal cross-over arm in which patients undergo 8 sessions using 8 randomized sub-convulsive stimulation protocols",[13],[28],{"type":29,"name":30,"description":31,"armGroupLabels":32,"otherNames":33},"PROCEDURE","Electroconvulsive Therapy","Electrical stimulation under anesthesia",[20,15,9,24],null,[35,40],{"name":36,"role":37,"phone":38,"phoneExt":33,"email":39},"Zachary Rosenthal, MD PhD","CONTACT","19738976511","Zachary.Rosenthal@pennmedicine.upenn.edu",{"name":41,"role":37,"phone":33,"phoneExt":33,"email":42},"Mario Cristancho, MD","marioc@pennmedicine.upenn.edu",[44],{"facility":45,"status":33,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"Pennsylvania Hospital","Philadelphia","Pennsylvania","19146","United States","US",{"type":52,"coordinates":53},"Point",[54,55],-75.16362,39.95238,{"lat":55,"lon":54},[58],{"name":59,"role":37,"phone":60,"phoneExt":33,"email":39},"Zachary Rosenthal","9738976511",{"type":62,"investigatorFullName":63,"investigatorTitle":64,"investigatorAffiliation":5,"oldNameTitle":33,"oldOrganization":33},"PRINCIPAL_INVESTIGATOR","Zach Rosenthal","Attending Physician","100636101","optimizing-stimulation-parameters-for-electroconvulsive-therapy-100636101",false,"NCT07561307","Optimizing Stimulation Parameters for Electroconvulsive Therapy","Parameter Refinement for ECT Stimulation and Titration Optimization","PRESTO","Inclusion Criteria:\n\n* Any patients being treated with electroconvulsive therapy at Pennsylvania Hospital who are willing and able to participate are eligible to be subjects in this study.\n\nExclusion Criteria:\n\n1. They are unwilling or unable to consent first to the SWEET COMBO protocol for optical monitoring during ECT\n2. Clinically significant psychiatric comorbidity as determined by clinical interview and in the opinion of the Investigator and clinical team would alter the risk\u002Fbenefit of the study\n3. History of poor response to ECT treatment in the opinion of the Investigator and clinical team that would alter the risk\u002Fbenefit of the study\n4. Presence of any disease, medical condition or physical condition that, in the opinion of the Investigator, may compromise, interfere with, limit, affect or reduce the:\n\n   1. subject's ability to participate safely in the study\n   2. integrity of the data or\n   3. subject's ability to complete the full duration of the study.","ALL",{"count":75,"type":76},64,"ESTIMATED","INTERVENTIONAL",[79],"NA","The goal of this clinical trial is to improve how electroconvulsive therapy (ECT) stimulation settings are chosen. Researchers will use real-time brain monitoring to measure both seizures and a recently identified brain event called cortical spreading depolarization (CSD).\n\nThe main questions it aims to answer are:\n\nWhat is the best way to increase ECT stimulation settings? How do different pulse settings affect the brain's response? Can certain settings produce CSD without causing a seizure?\n\nParticipants already receiving ECT as part of their care will take part. They will be assigned to one of two groups:\n\nIndex ECT group: Participants starting ECT will receive different standard titration approaches.\n\nMaintenance ECT group: Participants receiving ongoing ECT will undergo a brief, low-dose stimulation test before treatment.\n\nAll participants will be monitored using brain physiology (EEG and blood flow) and symptom scales during treatment.",[82,83],"Depression - Major Depressive Disorder","Catatonia",[85],"electroconvulsive therapy","NOT_YET_RECRUITING","2026-04-23",{"date":89,"type":90},"2026-05-01","ACTUAL",{"date":92,"type":76},"2026-07-01",{"date":94,"type":76},"2030-06-30",{"name":5,"class":6},1]