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Rodriguez",{"facility":683,"status":72,"city":672,"state":10,"zip":684,"country":607,"countryCode":608,"cosmosGeoPoint":685,"geoPoint":687,"contacts":688},"Hospital Universitario La Paz","28046",{"type":79,"coordinates":686},[676,677],{"lat":677,"lon":676},[689],{"name":690,"role":66,"phone":10,"phoneExt":10,"email":10},"Claudia Morrugares Portero",{"facility":692,"status":72,"city":672,"state":10,"zip":693,"country":607,"countryCode":608,"cosmosGeoPoint":694,"geoPoint":696,"contacts":697},"CIOSS HM Sanchinarro","28050",{"type":79,"coordinates":695},[676,677],{"lat":677,"lon":676},[698],{"name":699,"role":66,"phone":10,"phoneExt":10,"email":10},"Begoña Martinez Montesino",{"facility":701,"status":72,"city":702,"state":10,"zip":703,"country":607,"countryCode":608,"cosmosGeoPoint":704,"geoPoint":708,"contacts":709},"Hospital Universitario Virgen de la Victoria","Málaga","29010",{"type":79,"coordinates":705},[706,707],-4.42034,36.72016,{"lat":707,"lon":706},[710],{"name":711,"role":66,"phone":10,"phoneExt":10,"email":10},"Juan Manuel Escandell",{"facility":713,"status":72,"city":714,"state":10,"zip":715,"country":607,"countryCode":608,"cosmosGeoPoint":716,"geoPoint":720,"contacts":721},"CCS Hospital Universitari Parc Taulí","Sabadell","08208",{"type":79,"coordinates":717},[718,719],2.10942,41.54329,{"lat":719,"lon":718},[722],{"name":723,"role":66,"phone":10,"phoneExt":10,"email":10},"Jose Garcia Ruiz",{"facility":725,"status":72,"city":726,"state":10,"zip":727,"country":607,"countryCode":608,"cosmosGeoPoint":728,"geoPoint":732,"contacts":733},"Hospital Clinico de Santiago de Compostela","Santiago de Compostela","15706",{"type":79,"coordinates":729},[730,731],-8.54569,42.88052,{"lat":731,"lon":730},[734],{"name":735,"role":66,"phone":10,"phoneExt":10,"email":10},"Iria Portos",{"facility":737,"status":72,"city":738,"state":10,"zip":739,"country":607,"countryCode":608,"cosmosGeoPoint":740,"geoPoint":744,"contacts":745},"Hospital Clínico de Valencia","Valencia","46010",{"type":79,"coordinates":741},[742,743],-0.37966,39.47391,{"lat":743,"lon":742},[746],{"name":747,"role":66,"phone":10,"phoneExt":10,"email":10},"Matteo Stocco",{"type":749,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100443825","oracle-observation-of-residual-cancer-with-liquid-biopsy-evaluation-100443825",false,"NCT05059444","ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation","ORACLE","Inclusion Criteria:\n\n* Age \\> 18 years old AND\n* Initial treatment is given with curative\u002Fradical intent AND\n* Are planning to undergo regular follow-up and monitoring for cancer recurrence per standard of care at the enrolling site AND\n* Provided written informed consent to participate in the study AND\n* Are willing to have de-identified clinical data shared with investigators at regular intervals as outlined in the study protocol and informed consent AND\n* Are willing to provide blood samples at enrollment and at subsequent clinical visits coinciding with standard of care follow-up, for up to 5 years as outlined in the study protocol and informed consent AND\n* Have at least one Landmark blood sample\n\nHave a histologically confirmed Index Cancer that qualifies for inclusion, defined as:\n\nPrimary Study Cohorts\n\n* Cohort 1: Cohort 1: Muscle invasive carcinoma of the bladder, ureter, or renal pelvis (stage II-III),\n* Cohort 2: Cohort 2: Non-small cell lung cancer (stage IB-III):\n\nCohort 2A: Resectable OR Cohort 2B: Unresectable,\n\n* Cohort 3: Invasive breast carcinoma with hormone receptor (e.g. estrogen receptor (ER) and progesterone receptor (PR) expression) and human epidermal growth factor receptor 2 (HER2) status known and one the following:\n\nCohort 3A: High-risk2 HER2+ breast cancer (any ER, PR status allowed) OR Cohort 3B: High-risk2 triple negative breast cancer (TNBC) OR Cohort 3C: High-risk3 HR-positive\u002FHER2-negative invasive breast carcinoma,\n\n* Cohort 4: Stage IIB-III cutaneous melanoma or limited (resectable) stage IV melanoma treated with curative intent,\n* Cohort 5: Esophageal or gastroesophageal junction carcinoma (stage II-III),\n* Cohort 6: Gastric adenocarcinoma (stage II-III),\n* Cohort 7: Pancreatic adenocarcinoma that is has been surgically resected or is eligible for surgical resection,\n* Cohort 8: Invasive squamous cell carcinoma of the head and neck (Includes stage I-IVB oral cavity, oropharynx, hypopharynx, larynx, nasopharynx, nasal cavity, and paranasal sinus cancers),\n* Cohort 9: High-risk epithelial ovarian or Fallopian tube carcinoma (Defined as FIGO stage IC-III or stage IA-IB that has high grade or clear cell histology),\n* Cohort 10: High-risk endometrial carcinoma (Defined as 2023 FIGO Stage II-III),\n* Cohort 11: High-risk renal cell carcinoma (Defined as high grade (grade 3-4) stage II, stage III or limited (resectable) stage IV treated with curative intent)\n\nExploratory Cohort\n\n* Cohort 12: Pathologically confirmed adenocarcinoma of the rectum (located up to 15 cm from the anal verge) that is undergoing or underwent a preoperative chemotherapy- or immunotherapy- containing regimen\n\nExclusion Criteria:\n\n* History of allogeneic organ or tissue transplant\n* Index cancer has predominantly neuroendocrine histology\n* History of another primary cancer diagnosed within 3 years of enrollment, with the exception that in situ cancers, non-melanoma skin carcinomas, localized low- or intermediate risk prostate cancers, and stage I papillary thyroid carcinoma, and participants with bilateral\u002Fmultifocal tumors within the same organ (for example, bilateral breast cancer) are allowed if diagnosed within 3 years of enrollment\n* Known distant metastasis at time of enrollment (with the exception of participants with limited\u002Fresectable stage IV cutaneous melanoma or RCC)","ALL","18 Years",{"count":760,"type":761},2020,"ESTIMATED","OBSERVATIONAL","The purpose of ORACLE is to demonstrate the ability of a novel ctDNA assay developed by Guardant Health to detect recurrence in individuals treated for early-stage solid tumors. It is necessary that ctDNA test results are linked to clinical outcomes in order to demonstrate clinical validity for recurrence detection and explore its value in a healthcare environment subject to cost containment.",[765,766,767,768,769,770,771,772,773,774,775,776,777,778,779,780],"Bladder Carcinoma","Ureter Carcinoma","Renal Pelvis Carcinoma","Non-small Cell Lung Cancer","Invasive Breast Carcinoma","Cutaneous Melanoma","Esophageal Carcinoma","Gastroesophageal Junction Carcinoma","Gastric Adenocarcinoma","Pancreatic Adenocarcinoma","Squamous Cell Carcinoma of the Head and Neck","Epithelial Ovarian Carcinoma","Fallopian Tube Carcinoma","Endometrial Carcinoma","Renal Cell Carcinoma","Rectal Adenocarcinoma","2025-08-18",{"date":783,"type":784},"2025-08-22","ACTUAL",{"date":786,"type":784},"2021-09-07",{"date":788,"type":761},"2029-08",{"name":5,"class":6},57]