[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100473379":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":32,"centralContacts":37,"locations":47,"responsibleParty":79,"collaborators":10,"id":81,"slug":82,"hasResults":83,"nctId":84,"briefTitle":85,"officialTitle":85,"acronym":86,"eligibilityCriteria":87,"healthyVolunteers":88,"sex":89,"minAge":90,"maxAge":10,"enrollmentInfo":91,"targetDuration":10,"studyType":94,"phases":10,"briefSummary":95,"conditions":96,"keywords":10,"overallStatus":67,"whyStopped":10,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":107},{"fullName":5,"class":6},"Fondation Ophtalmologique Adolphe de Rothschild","NETWORK",[8,16],{"label":9,"type":10,"description":11,"interventionNames":12},"Cases",null,"patients with hepatic form of Wilson disease and those with neurological form",[13,14,15],"Other: Saliva samples","Other: Questionnaire OHIP-14","Other: Thorough dental examination",{"label":17,"type":10,"description":18,"interventionNames":19},"controls","control population consulting in routine dental with panoramic dental imaging, outside of an emergency context",[14,15],[21,26,29],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":10},"OTHER","Saliva samples","A saliva sample is added by research for all patients, as well as an oral quality of life questionnaire. For the witnesses, participation also entails the completion of the standardized oral examination (potentially longer than the assessment that would have been carried out as part of the treatment) and the administration of the oral quality of life questionnaire.",[9],{"type":22,"name":27,"description":24,"armGroupLabels":28,"otherNames":10},"Questionnaire OHIP-14",[9,17],{"type":22,"name":30,"description":24,"armGroupLabels":31,"otherNames":10},"Thorough dental examination",[9,17],[33],{"name":34,"affiliation":35,"role":36},"Marjolaine GOSSET","Hopital Charles Foix","STUDY_DIRECTOR",[38,43],{"name":39,"role":40,"phone":41,"phoneExt":10,"email":42},"Amélie YAVCHITZ","CONTACT","01 48 03 64 54","ayavhitz@for.paris",{"name":44,"role":40,"phone":45,"phoneExt":10,"email":46},"Aurélia POUJOIS","01 48 30 66 56","apoujois@for.paris",[48,60,65],{"facility":35,"status":49,"city":50,"state":10,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":10},"ACTIVE_NOT_RECRUITING","Ivry-sur-Seine","94200","France","FR",{"type":55,"coordinates":56},"Point",[57,58],2.38487,48.81568,{"lat":58,"lon":57},{"facility":61,"status":49,"city":50,"state":10,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":62,"geoPoint":64,"contacts":10},"Hôpital Charles Foix",{"type":55,"coordinates":63},[57,58],{"lat":58,"lon":57},{"facility":66,"status":67,"city":68,"state":10,"zip":69,"country":52,"countryCode":53,"cosmosGeoPoint":70,"geoPoint":74,"contacts":75},"Fondation Adolphe de Rothschild","RECRUITING","Paris","75019",{"type":55,"coordinates":71},[72,73],2.3488,48.85341,{"lat":73,"lon":72},[76],{"name":77,"role":40,"phone":78,"phoneExt":10,"email":46},"Aurélia Poujois","0148036656",{"type":80,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100473379","oral-health-and-wilsons-disease-somawi-100473379",false,"NCT05444127","Oral Health and Wilson's Disease: SOMAWI","SOMAWI","Inclusion Criteria:\n\n* Express consent to participate in the study\n* Member of or beneficiary of a social security scheme\n* For cases: Affected by Wilson's disease\n* For controls: Benefiting from a first routine dental consultation with dental panoramic imaging, outside of an emergency context or treatment follow-up\u002Fmaintenance\n\nExclusion Criteria:\n\n* Patient benefiting from a legal protection measure\n* Pregnant or breastfeeding women\n* Severe psychiatric disorders with behavioral disorders\n* For cases:\n\n  * hepatic or neurological decompensation\n  * liver transplant patient\n* For witnesses:\n\n  * Patient with hepatic or neurological disease\n  * Patient taking dietary supplements enriched with copper or zinc or zinc supplementation\n  * Patient wearing removable prostheses with zinc-enriched prosthetic adhesives (Fixodent ProPlus®)",true,"ALL","18 Years",{"count":92,"type":93},150,"ESTIMATED","OBSERVATIONAL","Patients with Wilson disease have poorer dental and periodontal health and a have lower oral quality of life than control patients. Patients with a neurological form would also more frequently present limitations in the function of the masticatory apparatus. Systemic treatments for Wilson disease are associated with lesions of the oral mucosa. Analysis of copper level in saliva could testify to the effectiveness of copper depletion in treated patients The main objective is to compare the state of dental health between: patients with Wilson disease in the hepatic form and patients with the neurological form, and a population of controls.",[97],"Wilson Disease","2025-12-09",{"date":100,"type":101},"2025-12-17","ACTUAL",{"date":103,"type":101},"2023-05-17",{"date":105,"type":93},"2026-10",{"name":5,"class":6},3]