[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100619426":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":29,"centralContacts":37,"locations":43,"responsibleParty":68,"collaborators":29,"id":72,"slug":73,"hasResults":74,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":29,"eligibilityCriteria":78,"healthyVolunteers":74,"sex":79,"minAge":80,"maxAge":81,"enrollmentInfo":82,"targetDuration":29,"studyType":85,"phases":86,"briefSummary":88,"conditions":89,"keywords":29,"overallStatus":45,"whyStopped":29,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":100,"completionDateStruct":101,"leadSponsor":103,"locationsCount":104},{"fullName":5,"class":6},"Tanta University","OTHER",[8,14,20],{"label":9,"type":10,"description":11,"interventionNames":12},"Group C (Control Group)","PLACEBO_COMPARATOR","Patients will be receive one oral placebo capsule the evening before surgery, one oral placebo capsule 2 hours prior to surgery, and one oral placebo capsule in the morning and one in the evening for 3 consecutive days postoperatively.",[13],"Other: Placebo capsule",{"label":15,"type":16,"description":17,"interventionNames":18},"Group M (Melatonin Group)","EXPERIMENTAL","Participants will receive one 5 mg oral melatonin capsule the evening before surgery, one 5 mg oral melatonin capsule 2 hours prior to surgery, and one oral placebo capsule in the morning, and one 5 mg oral melatonin capsule in the evening, daily for 3 consecutive days postoperatively.",[19],"Drug: Melatonin capsule",{"label":21,"type":16,"description":22,"interventionNames":23},"Group P (Pregabalin Group)","Participants will receive one 75 mg oral pregabalin capsule the evening before surgery, one 75 mg oral pregabalin capsule 2 hours prior to surgery, and one 75 mg oral pregabalin capsule in the morning, and another in the evening, daily for 3 consecutive days postoperatively.",[24],"Drug: Pregabalin capsule",[26,30,34],{"type":6,"name":27,"description":11,"armGroupLabels":28,"otherNames":29},"Placebo capsule",[9],null,{"type":31,"name":32,"description":17,"armGroupLabels":33,"otherNames":29},"DRUG","Melatonin capsule",[15],{"type":31,"name":35,"description":22,"armGroupLabels":36,"otherNames":29},"Pregabalin capsule",[21],[38],{"name":39,"role":40,"phone":41,"phoneExt":29,"email":42},"Ahmed H Ayad, MSc","CONTACT","00201009598637","Ahmed.hamdy@med.tanta.edu.eg",[44],{"facility":5,"status":45,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"RECRUITING","Tanta","El-Gharbia","31527","Egypt","EG",{"type":52,"coordinates":53},"Point",[54,55],31.00192,30.78847,{"lat":55,"lon":54},[58,59,62,64,66],{"name":39,"role":40,"phone":41,"phoneExt":29,"email":42},{"name":60,"role":61,"phone":29,"phoneExt":29,"email":29},"Shaimaa F Mostafa, MD","SUB_INVESTIGATOR",{"name":63,"role":61,"phone":29,"phoneExt":29,"email":29},"Gehan M Morsy, MD",{"name":65,"role":61,"phone":29,"phoneExt":29,"email":29},"Laila A Elahwal, MD",{"name":67,"role":61,"phone":29,"phoneExt":29,"email":29},"Ahmed E Abo Elhkair, MD",{"type":69,"investigatorFullName":70,"investigatorTitle":71,"investigatorAffiliation":5,"oldNameTitle":29,"oldOrganization":29},"PRINCIPAL_INVESTIGATOR","Ahmed Hamdy Said Ayad","Assistant lecturer of Anesthesia, Surgical Intensive Care and Pain Medicine, Tanta University, Tanta, Egypt.","100619426","oral-melatonin-versus-oral-pregabalin-on-postoperative-pain-and-anxiety-following-spine-surgery-100619426",false,"NCT07344467","Oral Melatonin Versus Oral Pregabalin on Postoperative Pain and Anxiety Following Spine Surgery","Effect of Oral Melatonin Versus Oral Pregabalin on Postoperative Pain and Anxiety Following Spine Surgery: A Prospective, Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients aged 21-60 years old.\n* Both sexes.\n* Patients of American Society of Anesthesiologists (ASA) physical status I \\& II.\n* Undergoing elective spine surgery.\n\nExclusion Criteria:\n\n* Patient refusal.\n* History of allergic reactions to melatonin or pregabalin.\n* Patients with cardiovascular disease (ischemic heart disease, Heart Failure, Arrythmia, Heart Block).\n* Patients with kidney disease with (plasma creatinine level \\> 1.5mg\u002Fdl).\n* Patients with liver disease with (aspartate transaminase, alanine transaminase, and bilirubin levels more than twice the upper limit of normal).\n* Psychological and cognitive disorders; dementia; major depression.\n* Circadian rhythm disorders such as chronic fatigue syndrome and drowsiness.","ALL","21 Years","60 Years",{"count":83,"type":84},105,"ESTIMATED","INTERVENTIONAL",[87],"NA","This study aims to compare the efficacy of using Melatonin versus Pregabalin on postoperative pain and anxiety after spine surgeries.",[90,91,92,93,94,95],"Oral","Melatonin","Pregabalin","Postoperative Pain","Anxiety","Spine Surgery","2026-01-17",{"date":98,"type":99},"2026-01-21","ACTUAL",{"date":96,"type":99},{"date":102,"type":84},"2027-06-01",{"name":5,"class":6},1]