[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100622477":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":32,"centralContacts":37,"locations":46,"responsibleParty":60,"collaborators":26,"id":64,"slug":65,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":26,"eligibilityCriteria":70,"healthyVolunteers":71,"sex":72,"minAge":73,"maxAge":74,"enrollmentInfo":75,"targetDuration":26,"studyType":78,"phases":79,"briefSummary":81,"conditions":82,"keywords":84,"overallStatus":90,"whyStopped":26,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"BLIS Technologies Limited","INDUSTRY",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Oral probiotic lozenges","ACTIVE_COMPARATOR","Oral probiotic lozenges containing Streptococcus salivarius M18 and Streptococcus salivarius K12 and prebiotic",[13],"Dietary Supplement: In this study, a probiotic lozenge formulation containing S. salivarius K12, M18 and prebiotic will be evaluated for its potential to improve bad breath",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo lozenges","PLACEBO_COMPARATOR","Oral lozenges",[19],"Other: Placebo",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DIETARY_SUPPLEMENT","In this study, a probiotic lozenge formulation containing S. salivarius K12, M18 and prebiotic will be evaluated for its potential to improve bad breath","In this study, a probiotic-free lozenge formulation containing S. salivarius K12, M18 and prebiotic will be evaluated for its potential to improve bad breath as a comparator.",[9],null,{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":26},"OTHER","Placebo","Probiotic free placebo lozenge",[15],[33],{"name":34,"affiliation":35,"role":36},"John R Tagg, PhD","BLIS Technologies Ltd","PRINCIPAL_INVESTIGATOR",[38,43],{"name":39,"role":40,"phone":41,"phoneExt":26,"email":42},"John D Hale, PhD","CONTACT","+6434740988","john.hale@blis.co.nz",{"name":44,"role":40,"phone":41,"phoneExt":26,"email":45},"Rohit Jain, PhD","rohit.jain@blis.co.nz",[47],{"facility":48,"status":26,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":26},"Blis Technologies Ltd","Dunedin","Otago","9012","New Zealand","NZ",{"type":55,"coordinates":56},"Point",[57,58],170.50361,-45.87416,{"lat":58,"lon":57},{"type":61,"investigatorFullName":62,"investigatorTitle":63,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"SPONSOR_INVESTIGATOR","John Hale","Chief Technology Officer","100622477","oral-probiotics-for-halitosis-in-healthy-adults-100622477",false,"NCT07384130","Oral Probiotics for Halitosis in Healthy Adults","Efficacy of Oral Probiotics on Cysteine-Induced Halitosis in Healthy Adult Volunteers.","Inclusion Criteria:\n\n* Participants should be otherwise healthy,\n* practice good oral hygiene,\n* 18 - 70 years of age\n\nExclusion Criteria:\n\n* on antibiotic therapy,\n* immunocompromised (have a weakened immune system)\n* history of autoimmune disease,\n* allergy or sensitivity to dairy,\n* have an active periodontal disease, any known allergy or sensitivity to components of the test product or cysteine solution.",true,"ALL","18 Years","70 Years",{"count":76,"type":77},40,"ESTIMATED","INTERVENTIONAL",[80],"NA","The aim of this study is to evaluate efficacy of a probiotic lozenge containing BLIS M18, BLIS K12 and a prebiotic in healthy adults.",[83],"Halitosis",[85,86,87,88,89],"oral probiotic","halitosis","Streptococcus salivarius M18","Streptococcus salivarius K12","chewable tablet","NOT_YET_RECRUITING","2026-02-02",{"date":93,"type":94},"2026-02-04","ACTUAL",{"date":96,"type":77},"2026-03-15",{"date":98,"type":77},"2026-07-15",{"name":62,"class":6},1]