[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100577638":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":10,"centralContacts":23,"locations":34,"responsibleParty":52,"collaborators":10,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":60,"eligibilityCriteria":61,"healthyVolunteers":62,"sex":63,"minAge":64,"maxAge":10,"enrollmentInfo":65,"targetDuration":10,"studyType":68,"phases":10,"briefSummary":69,"conditions":70,"keywords":71,"overallStatus":37,"whyStopped":10,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},{"fullName":5,"class":6},"Istituto Auxologico Italiano","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Anorexia Nervosa",null,"Young women with Anorexia Nervosa, hospitalized at the Division of Eating and Nutrition Disorders, Istituto Auxologico Italiano, IRCCS, Piancavallo, Italy,",[13],"Other: Blood samples and Questionnaires",{"label":15,"type":10,"description":16,"interventionNames":17},"Normal weight","Young women of comparable age with Body Mass Index between 18.5 and 24.9 kg\u002Fm2",[13],[19],{"type":6,"name":20,"description":21,"armGroupLabels":22,"otherNames":10},"Blood samples and Questionnaires","Blood samples for methylation of the promoter of the OX-A and OX-B genes and questionnaires:\n\nEating Disorder Examination Q Eating Disorder Inventory 3 Major Depression Inventory Symptom Checklist-revised ESS - Epworth Sleepiness Scale Pittsburgh Sleep Quality Index Horne \\& Ostberg questionnaire",[9,15],[24,30],{"name":25,"role":26,"phone":27,"phoneExt":28,"email":29},"Alessandro Sartorio, MD","CONTACT","+390261911","2426","sartorio@auxologico.it",{"name":31,"role":26,"phone":27,"phoneExt":32,"email":33},"Luca Grappiolo, Dr.","2894","luca.grappiolo@auxologico.it",[35],{"facility":36,"status":37,"city":38,"state":39,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"Istituto Auxologico Italiano IRCCS, Site Piancavallo","RECRUITING","Oggebbio","Verbania","28824","Italy","IT",{"type":44,"coordinates":45},"Point",[46,47],8.64663,45.99088,{"lat":47,"lon":46},[50],{"name":25,"role":26,"phone":51,"phoneExt":28,"email":29},"+39-02619111",{"type":53,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100577638","orexin-gene-in-anorexia-nervosa-100577638",false,"NCT06800898","Orexin Gene in Anorexia Nervosa","The Methylation Level of the Orexin Gene in Anorexia Nervosa: Relationship With Eating Disorder, Depressive State, and Sleep Quality","ORESSANNE","Patients with Anorexia Nervosa:\n\nInclusion Criteria:\n\n* Female sex\n* Age 18 years and older\n* Anorexia Nervosa\n* Hospitalized at the Division of Eating and Nutrition Disorders, Istituto Auxologico Italiano, IRCCS, Piancavallo, Italy\n\nExclusion Criteria:\n\n* Absence of signed informed consent\n\nControl group:\n\nInclusion Criteria:\n\n* Female sex\n* Age 18 years and older\n* Body Mass Index between 18.5 and 24.9 kg\u002Fm2\n\nExclusion Criteria:\n\n* Absence of signed informed consent\n* Presence of any physical and mental pathology",true,"FEMALE","18 Years",{"count":66,"type":67},60,"ESTIMATED","OBSERVATIONAL","The objectives of this study will be to determine the methylation of the promoter of the Orexin A (OX-A) and B (OX-B) genes in young women (\\> 18 years) with Anorexia Nervosa (AN), compared with a control group; and to evaluate the relationship of promoter methylation of the genes for OX-A and OX-B with the severity of the eating disorder, psychiatric comorbidities (in particular, depression), and sleep quality.",[9],[72,73,74,75,76,77],"Orexins","Methylation","Epigenetics","Psychiatric comorbidities","Eating disorder","Quality of sleep","2026-03-25",{"date":80,"type":81},"2026-03-30","ACTUAL",{"date":83,"type":81},"2024-06-19",{"date":85,"type":67},"2026-06-30",{"name":5,"class":6},1]