[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100510107":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":25,"centralContacts":30,"locations":36,"responsibleParty":56,"collaborators":25,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":64,"eligibilityCriteria":65,"healthyVolunteers":60,"sex":66,"minAge":67,"maxAge":25,"enrollmentInfo":68,"targetDuration":25,"studyType":71,"phases":72,"briefSummary":74,"conditions":75,"keywords":80,"overallStatus":39,"whyStopped":25,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},{"fullName":5,"class":6},"Second Affiliated Hospital, School of Medicine, Zhejiang University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Usual Diet advice","PLACEBO_COMPARATOR","Usual diet advice + standard medical treatment",[13],"Behavioral: Usual Diet advice",{"label":15,"type":16,"description":17,"interventionNames":18},"ORIENT diet intervention","ACTIVE_COMPARATOR","6 month intervention of ORIENT diet + standard medical treatment",[19],"Behavioral: Oriental Intervention for Enhanced Neurocognitive Health (ORIENT) diet",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"BEHAVIORAL","The usual diet advice include recommendations in guidelines, such as reducing salt and limiting alcohol consumption",[9],null,{"type":22,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Oriental Intervention for Enhanced Neurocognitive Health (ORIENT) diet","The ORIENT diet has the same basic components of the Dietary Approaches to Stop Hypertension (DASH), Mediterranean and MIND diets, but uniquely adjusting some of components according to the evidence derived from Asian prospective cohorts and the Chinese eating habits.",[15],[31],{"name":32,"role":33,"phone":34,"phoneExt":25,"email":35},"Min Lou, PhD, MD","CONTACT","13958007213","lm99@zju.edu.cn",[37],{"facility":38,"status":39,"city":40,"state":41,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"Second Affilated Hospital of Zhejiang University, School of Medicine","RECRUITING","Hangzhou","Zhejiang","310009","China","CN",{"type":46,"coordinates":47},"Point",[48,49],120.16142,30.29365,{"lat":49,"lon":48},[52,53],{"name":32,"role":33,"phone":34,"phoneExt":25,"email":35},{"name":54,"role":55,"phone":25,"phoneExt":25,"email":25},"Changzheng Yuan, ScD","PRINCIPAL_INVESTIGATOR",{"type":57,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100510107","oriental-intervention-for-enhanced-neurocognitive-health-orient-diet-in-patients-with-intracranial--carotid-stenosis-100510107",false,"NCT05922137","Oriental Intervention for Enhanced Neurocognitive Health (ORIENT) Diet in Patients With Intracranial \u002F Carotid Stenosis","Oriental Intervention for Enhanced Neurocognitive Health (ORIENT) Diet in Patients With Intracranial \u002F Carotid Stenosis : a Randomized Controlled Trial","ORIENT","Inclusion Criteria:\n\n* Patients aged ≥ 40 years\n* ≥ 50% stenosis in unilateral intracranial \u002F carotid artery\n* Written informed consent available\n* Willingness to complete all assessments and participate in follow-up\n* Adequate Visual and auditory acuity to undergo neuropsychological testing\n\nExclusion Criteria:\n\n* Previous history of major head trauma and any intracranial surgery\n* Intracranial abnormalities, such as intracerebral hemorrhage, subarachnoid hemorrhage and other space occupying lesions\n* Extrapyramidal symptoms or mental illness which may affect neuropsychological measurement\n* Severe loss of vision, hearing, or communicative ability\n* Nuts, berries, olive oil, or fish allergies\n* Patients presenting a malignant disease with life expectancy \\\u003C 3 years\n* Participation in an ongoing investigational drug study\n\nExit Criteria:\n\n* Not meet the inclusion criteria\n* For any poor adherence, not comply with the requirements of the follow-up, or safety reasons determined by investigator\n* Any adverse or serious adverse events during the study period judged by Investigator","ALL","40 Years",{"count":69,"type":70},120,"ESTIMATED","INTERVENTIONAL",[73],"NA","To test the effects of 6 month additional intervention of ORIENT diet versus usual medical treatment for Intracranial \u002F Carotid Stenosis on cognitive decline, multi-mode MRI image markers and serum and fecal biomarkers in a randomized controlled trial of 120 patients with intracranial \u002F carotid stenosis, who are aged older than 40 years and without dementia.",[76,77,78,79],"Cognitive Decline","Cognitive Change","Stenosis","Dementia",[81],"Cognitive decline","2025-06-11",{"date":84,"type":85},"2025-06-15","ACTUAL",{"date":87,"type":85},"2023-05-01",{"date":89,"type":70},"2027-05-31",{"name":5,"class":6},1]