[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100626159":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":12,"locations":18,"responsibleParty":112,"collaborators":116,"id":120,"slug":121,"hasResults":122,"nctId":123,"briefTitle":124,"officialTitle":125,"acronym":126,"eligibilityCriteria":127,"healthyVolunteers":128,"sex":129,"minAge":130,"maxAge":10,"enrollmentInfo":131,"targetDuration":10,"studyType":134,"phases":10,"briefSummary":135,"conditions":136,"keywords":142,"overallStatus":153,"whyStopped":10,"lastUpdateSubmitDate":154,"lastUpdatePostDateStruct":155,"startDateStruct":158,"completionDateStruct":160,"leadSponsor":162,"locationsCount":163},{"fullName":5,"class":6},"Tomas Bata Hospital, Czech Republic","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Cohort of older adults undergoing elective total hip arthroplasty",null,"Prospective cohort of patients aged 65 years and older undergoing elective total hip arthroplasty in standard clinical care. All participants receive routine perioperative management. No interventions are assigned as part of the study.",[13],{"name":14,"role":15,"phone":16,"phoneExt":10,"email":17},"Klára Nekvindová, M.D, Ph.D.","CONTACT","+420577 551 111","nekvindova.klara@gmail.com",[19,35,49,62,76,87,100],{"facility":20,"status":10,"city":21,"state":10,"zip":22,"country":23,"countryCode":10,"cosmosGeoPoint":24,"geoPoint":29,"contacts":30},"University Hospital Brno - Bohunice","Brno","62500","Czechia",{"type":25,"coordinates":26},"Point",[27,28],16.60796,49.19522,{"lat":28,"lon":27},[31],{"name":32,"role":15,"phone":33,"phoneExt":10,"email":34},"Vrbica Kamil, M.D.","+ 420 532 23 1111","vrbica.kamil@fnbrno.cz",{"facility":36,"status":10,"city":37,"state":10,"zip":38,"country":23,"countryCode":10,"cosmosGeoPoint":39,"geoPoint":43,"contacts":44},"University Hospital Olomouc - Department of Anaesthesiology, Resuscitation and Intensive Care","Olomouc","77900",{"type":25,"coordinates":40},[41,42],17.25175,49.59552,{"lat":42,"lon":41},[45],{"name":46,"role":15,"phone":47,"phoneExt":10,"email":48},"Lenka Doubravska, M.D.","+420 585 851 111","Lenka.Doubravska@fnol.cz",{"facility":50,"status":10,"city":51,"state":10,"zip":10,"country":23,"countryCode":10,"cosmosGeoPoint":52,"geoPoint":56,"contacts":57},"University Hospital Ostrava - Department of Anaesthesiology, Resuscitation and Intensive Care","Ostrava",{"type":25,"coordinates":53},[54,55],18.28204,49.83465,{"lat":55,"lon":54},[58],{"name":59,"role":15,"phone":60,"phoneExt":10,"email":61},"Jan Neiser, M.D.","+420 597 371 111","Jan.Neiser@fno.cz",{"facility":63,"status":10,"city":64,"state":10,"zip":65,"country":23,"countryCode":10,"cosmosGeoPoint":66,"geoPoint":70,"contacts":71},"University Hospital Královské Vinohrady","Prague","10034",{"type":25,"coordinates":67},[68,69],14.42076,50.08804,{"lat":69,"lon":68},[72],{"name":73,"role":15,"phone":74,"phoneExt":10,"email":75},"Jiří Málek, doc, M.D., Ph.D.","+420267 161 111","jiri.malek@fnkv.cz",{"facility":77,"status":10,"city":64,"state":10,"zip":78,"country":23,"countryCode":10,"cosmosGeoPoint":79,"geoPoint":81,"contacts":82},"University Hospital Motol","15006",{"type":25,"coordinates":80},[68,69],{"lat":69,"lon":68},[83],{"name":84,"role":15,"phone":85,"phoneExt":10,"email":86},"Tomáš Brož, M.D.","+420 224 431 111","tomas.broz@fnmotol.cz",{"facility":88,"status":10,"city":89,"state":10,"zip":10,"country":23,"countryCode":10,"cosmosGeoPoint":90,"geoPoint":94,"contacts":95},"Vsetín Hospital","Vsetín",{"type":25,"coordinates":91},[92,93],17.99619,49.33871,{"lat":93,"lon":92},[96],{"name":97,"role":15,"phone":98,"phoneExt":10,"email":99},"Marek Proksa, M.D.","+420571 818 111","proksa@nemocnice-vs.cz",{"facility":101,"status":10,"city":102,"state":10,"zip":103,"country":23,"countryCode":10,"cosmosGeoPoint":104,"geoPoint":108,"contacts":109},"Tomas Bata Regional Hospital","Zlín","6275",{"type":25,"coordinates":105},[106,107],17.67065,49.22645,{"lat":107,"lon":106},[110],{"name":111,"role":15,"phone":16,"phoneExt":10,"email":17},"Klára Nekvindová, M.D., Ph.D.",{"type":113,"investigatorFullName":114,"investigatorTitle":115,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Klára Nekvindová","Principal Investigator, Department of Anesthesiology, Resuscitation and Intensive Car",[117],{"name":118,"class":119},"Czech Clinical Research Infrastructure Network","UNKNOWN","100626159","orthopedic-procedures-and-postoperative-delirium-in-older-adults-in-the-czech-republic-100626159",false,"NCT07432009","Orthopedic Procedures and Postoperative Delirium in Older Adults in the Czech Republic","Orthopedic Procedures and Postoperative Delirium in the Czech Republic","ORTOPODCZ","Inclusion Criteria:\n\n* Age ≥ 65 years\n* Elective total hip arthroplasty in general or regional anesthesia\n* ASA physical status I-III\n* Ability to understand and cooperate during testing; no severe sensory impairment (compensatory aids allowed)\n* Expected postoperative hospitalization in ICU, PACU, or standard ward\n\nExclusion Criteria:\n\n* Glasgow Coma Scale ≤ 14\n* Limited legal capacity\n* Active psychiatric disorder (e.g., psychotic disorder, bipolar disorder)\n* Active oncological disease\n* Chronic use of strong opioids\n* Premedication with anxiolytics or antipsychotics during preanesthetic evaluation\n* Acute reoperation within 3 months of primary surgery\n* Refusal to participate or withdrawal of consent",true,"ALL","65 Years",{"count":132,"type":133},400,"ESTIMATED","OBSERVATIONAL","This multicenter, prospective, non-interventional observational study (ORTOPODCZ) investigates the association between preoperative cognitive impairment and postoperative delirium (POD) in older adults undergoing elective total hip arthroplasty in the Czech Republic. Postoperative delirium is a frequent and serious neurocognitive complication in senior surgical patients and is associated with increased morbidity, mortality, prolonged hospitalization, and impaired functional and cognitive outcomes. Despite international recommendations, routine preoperative cognitive screening remains insufficiently implemented.\n\nThe study evaluates the predictive value of the ALBA test, a brief cognitive screening tool, performed during the pre-anesthetic assessment. Postoperative delirium will be assessed using the validated CAM-ICU instrument for up to 72 hours after surgery. Secondary objectives include assessing the relationship between POD and frailty, polypharmacy, comorbidities, type of anesthesia, intraoperative hemodynamics, blood loss, vasoactive support, and postoperative complications.\n\nApproximately 300-400 participants aged ≥65 years will be enrolled across seven centers. No additional procedures, biological sampling, or deviations from standard clinical care are required. Data will be collected in REDCap and analyzed according to a predefined statistical analysis plan. The study aims to provide robust evidence supporting the integration of cognitive screening into routine preoperative evaluation and to describe feasibility and implementation requirements for the ALBA test in clinical practice.",[137,138,139,140,141],"Frailty","Cognitive Impairment","Older Adults","Hip Arthroplasty","Postoperative Delirium",[143,144,145,146,147,148,149,150,151,152],"ALBA test","CAM-ICU","Cognitive Screening","Geriatric Patients","Perioperative Neurocognitive Disorders","Polypharmacy","Clinical Frailty Scale","Total Hip Replacement","Observational Study","Prospective Cohort","NOT_YET_RECRUITING","2026-02-24",{"date":156,"type":157},"2026-02-25","ACTUAL",{"date":159,"type":133},"2026-04-01",{"date":161,"type":133},"2030-03-31",{"name":5,"class":6},7]