[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100630309":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":12,"centralContacts":16,"locations":21,"responsibleParty":35,"collaborators":10,"id":38,"slug":39,"hasResults":40,"nctId":41,"briefTitle":42,"officialTitle":43,"acronym":44,"eligibilityCriteria":45,"healthyVolunteers":40,"sex":46,"minAge":47,"maxAge":10,"enrollmentInfo":48,"targetDuration":10,"studyType":51,"phases":10,"briefSummary":52,"conditions":53,"keywords":56,"overallStatus":64,"whyStopped":10,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":74},{"fullName":5,"class":6},"University Medical Centre Ljubljana","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Adults aged 65 years and older hospitalized in internal medicine departments at the University Medic",null,"Adults aged 65 years and older hospitalized in internal medicine departments at the University Medical Centre Ljubljana. Participants will undergo orthostatic and postprandial blood pressure measurements and comprehensive geriatric assessment, including evaluation of functional status, cognitive status, frailty, and other geriatric syndromes. Participants will be followed for up to 12 months to assess clinical outcomes.",[13],{"name":14,"affiliation":5,"role":15},"Amela Kabaklić, MD, PhD","PRINCIPAL_INVESTIGATOR",[17],{"name":14,"role":18,"phone":19,"phoneExt":10,"email":20},"CONTACT","+386 1 522 43 05","amela.kabaklic@kclj.si",[22],{"facility":5,"status":10,"city":23,"state":10,"zip":24,"country":25,"countryCode":26,"cosmosGeoPoint":27,"geoPoint":32,"contacts":33},"Ljubljana","1000","Slovenia","SI",{"type":28,"coordinates":29},"Point",[30,31],14.50513,46.05108,{"lat":31,"lon":30},[34],{"name":14,"role":18,"phone":19,"phoneExt":10,"email":20},{"type":15,"investigatorFullName":36,"investigatorTitle":37,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Amela Kabaklić","MD, PhD, Specialist in Internal Medicine","100630309","orthostatic-and-postprandial-hypotension-in-hospitalized-older-adults-hope65-100630309",false,"NCT07485998","Orthostatic And Postprandial Hypotension In Hospitalized Older Adults (HOPE65)","Orthostatic And Postprandial Hypotension In Hospitalized Older Adults: Prevalence And Association With Medications, Comorbidities, And Adverse Clinical Outcomes","HOPE65","Inclusion Criteria:\n\n* Age 65 years or older\n* Hospitalization in internal medicine departments at the University Medical Centre Ljubljana\n* Duration of hospitalization ≥48 hours\n* Hemodynamic stability confirmed by the treating physician\n* Ability to participate in study procedures\n* Ability to stand (with or without assistive devices for walking)\n* Written informed consent obtained\n\nExclusion Criteria:\n\n* Medical condition preventing study procedures (e.g., need for continuous supine position)\n* Inability to provide informed consent\n* Refusal to participate\n* Severe cognitive impairment or delirium\n* Acute critical illness requiring intensive treatment\n* Participation in another clinical study that could affect safety or study outcomes","ALL","65 Years",{"count":49,"type":50},500,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to determine how often orthostatic hypotension and postprandial hypotension occur in adults aged 65 years and older who are hospitalized in internal medicine departments.\n\nOrthostatic hypotension is defined as an excessive drop in blood pressure after standing up from a lying or sitting position. Postprandial hypotension is an excessive drop in blood pressure that occurs after eating a meal. These conditions can increase the risk of falls, fainting, loss of independence, and other health problems in older adults.\n\nThe main questions this study aims to answer are:\n\n* How common orthostatic hypotension and postprandial hypotension are in hospitalized adults aged 65 years and older.\n* Whether these conditions are associated with medication use, chronic diseases, and geriatric syndromes (such as frailty, cognitive impairment, and functional decline).\n\nParticipants will:\n\n* have blood pressure measured while lying down and standing\n* have blood pressure measured after a meal\n* undergo a comprehensive geriatric assessment, including evaluation of functional status, cognitive function, frailty, mobility, and nutritional status\n* provide information about medications and medical history\n* be followed for up to 12 months to record outcomes such as falls, syncope, hospitalization, and death",[54,55],"Orthostatic Hypotension","Postprandial Hypotension",[57,58,59,60,61,62,63],"Older Adults","Hospitalized Patients","Blood Pressure Regulation","Falls","Geriatric Syndromes","Comprehensive Geriatric Assessment","Antihypertensive Medication","NOT_YET_RECRUITING","2026-03-17",{"date":67,"type":68},"2026-03-20","ACTUAL",{"date":70,"type":50},"2026-04",{"date":72,"type":50},"2030-06",{"name":5,"class":6},1]