[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100495566":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":43,"locations":53,"responsibleParty":135,"collaborators":137,"id":150,"slug":151,"hasResults":152,"nctId":153,"briefTitle":154,"officialTitle":154,"acronym":155,"eligibilityCriteria":156,"healthyVolunteers":152,"sex":157,"minAge":158,"maxAge":159,"enrollmentInfo":160,"targetDuration":10,"studyType":163,"phases":10,"briefSummary":164,"conditions":165,"keywords":10,"overallStatus":70,"whyStopped":10,"lastUpdateSubmitDate":171,"lastUpdatePostDateStruct":172,"startDateStruct":175,"completionDateStruct":177,"leadSponsor":179,"locationsCount":180},{"fullName":5,"class":6},"Relation Therapeutics","INDUSTRY",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Participant undergoing orthopaedic surgery",null,"* Patients with osteoarthritis undergoing total joint arthroplasty, osteotomy or arthrodesis of any joint (including hip, knee, shoulder, elbow, ankle).\n* Patients with fractured neck of femurs undergoing hemiarthroplasty or total hip arthroplasty, or other internal fixation procedure.\n* Patients undergoing acute low-velocity or fragility fracture fixation surgery.",[13],"Procedure: Relevant orthopaedic surgery",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":10},"PROCEDURE","Relevant orthopaedic surgery","Inclusion criteria is purposefully broad to examine a range of discarded bone waste. Therefore, a large number of surgical interventions are relevant.",[9],[21,25,28,31,34,37,40],{"name":22,"affiliation":23,"role":24},"Raghbir Khakha","Harley Street Specialist Hospital & Fitzrovia Hospital\u002FQASMC","PRINCIPAL_INVESTIGATOR",{"name":26,"affiliation":27,"role":24},"Akash Patel","Royal Free London NHS Foundation Trust",{"name":29,"affiliation":30,"role":24},"Yegappan Kalairajah","Luton & Dunstable University Hospital, Bedfordshire Hospitals NHS Foundation Trust",{"name":32,"affiliation":33,"role":24},"Victor Babu","Chelsea and Westminster NHS Foundation Trust",{"name":35,"affiliation":36,"role":24},"Jonathan Ward","Barts & The London NHS Trust",{"name":38,"affiliation":39,"role":24},"Richard Keen","Royal National Orthopaedic Hospital NHS Trust",{"name":41,"affiliation":42,"role":24},"Ines Reichert","King's College Hospital NHS Trust",[44,49],{"name":45,"role":46,"phone":47,"phoneExt":10,"email":48},"Jake Taylor-King, DPhil","CONTACT","447387227904","jake@relationrx.com",{"name":50,"role":46,"phone":51,"phoneExt":10,"email":52},"Susan O'Connor","07513017280","susan.oconnor@blctrials.onmicrosoft.com",[54,68,79,89,102,113,118,125],{"facility":55,"status":56,"city":57,"state":58,"zip":59,"country":60,"countryCode":61,"cosmosGeoPoint":62,"geoPoint":67,"contacts":10},"Harley Street Specialist Hospital","ACTIVE_NOT_RECRUITING","London","Greater London","W1G 8HU","United Kingdom","UK",{"type":63,"coordinates":64},"Point",[65,66],-0.12574,51.50853,{"lat":66,"lon":65},{"facility":69,"status":70,"city":57,"state":10,"zip":10,"country":60,"countryCode":61,"cosmosGeoPoint":71,"geoPoint":73,"contacts":74},"Barts Health NHS Trust","RECRUITING",{"type":63,"coordinates":72},[65,66],{"lat":66,"lon":65},[75,78],{"name":76,"role":46,"phone":10,"phoneExt":10,"email":77},"Catherine Hilton","catherine.hilton1@nhs.net",{"name":35,"role":24,"phone":10,"phoneExt":10,"email":10},{"facility":80,"status":70,"city":57,"state":10,"zip":10,"country":60,"countryCode":61,"cosmosGeoPoint":81,"geoPoint":83,"contacts":84},"Chase Farm Hospital",{"type":63,"coordinates":82},[65,66],{"lat":66,"lon":65},[85,88],{"name":86,"role":46,"phone":10,"phoneExt":10,"email":87},"Olaoluwa Olaosebikan","olaoluwa.olaosebikan@nhs.net",{"name":26,"role":24,"phone":10,"phoneExt":10,"email":10},{"facility":90,"status":70,"city":57,"state":10,"zip":10,"country":60,"countryCode":61,"cosmosGeoPoint":91,"geoPoint":93,"contacts":94},"Fitzrovia Hospital\u002FQASMC",{"type":63,"coordinates":92},[65,66],{"lat":66,"lon":65},[95,98,101],{"name":96,"role":46,"phone":10,"phoneExt":10,"email":97},"Nazish Daudi","nazish.daudi@qasmc.com",{"name":99,"role":46,"phone":10,"phoneExt":10,"email":100},"Brian Leaker","brian.leaker@qasmc.com",{"name":22,"role":24,"phone":10,"phoneExt":10,"email":10},{"facility":103,"status":104,"city":57,"state":10,"zip":10,"country":60,"countryCode":61,"cosmosGeoPoint":105,"geoPoint":107,"contacts":108},"King's College Hospital","NOT_YET_RECRUITING",{"type":63,"coordinates":106},[65,66],{"lat":66,"lon":65},[109,112],{"name":110,"role":46,"phone":10,"phoneExt":10,"email":111},"Kerim Gokturk","agokturk@nhs.net",{"name":41,"role":24,"phone":10,"phoneExt":10,"email":10},{"facility":114,"status":56,"city":57,"state":10,"zip":10,"country":60,"countryCode":61,"cosmosGeoPoint":115,"geoPoint":117,"contacts":10},"Luton & Dunstable University Hospital",{"type":63,"coordinates":116},[65,66],{"lat":66,"lon":65},{"facility":39,"status":104,"city":57,"state":10,"zip":10,"country":60,"countryCode":61,"cosmosGeoPoint":119,"geoPoint":121,"contacts":122},{"type":63,"coordinates":120},[65,66],{"lat":66,"lon":65},[123,124],{"name":38,"role":46,"phone":10,"phoneExt":10,"email":10},{"name":38,"role":24,"phone":10,"phoneExt":10,"email":10},{"facility":126,"status":70,"city":57,"state":10,"zip":10,"country":60,"countryCode":61,"cosmosGeoPoint":127,"geoPoint":129,"contacts":130},"West Middlesex University Hospital",{"type":63,"coordinates":128},[65,66],{"lat":66,"lon":65},[131,134],{"name":132,"role":46,"phone":10,"phoneExt":10,"email":133},"Amrinder Sayan","amrinder.sayan@nhs.net",{"name":32,"role":24,"phone":10,"phoneExt":10,"email":10},{"type":136,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[138,140,142,145,147,148,149],{"name":55,"class":139},"UNKNOWN",{"name":141,"class":139},"Fitzrovia Hospital",{"name":143,"class":144},"Royal Free Hospital NHS Foundation Trust","OTHER",{"name":146,"class":144},"Bedfordshire Hospitals NHS Foundation Trust",{"name":33,"class":144},{"name":36,"class":144},{"name":39,"class":144},"100495566","osteomics-identifying-regulators-of-bone-homeostasis-100495566",false,"NCT05732870","OSTEOMICS: Identifying Regulators of Bone Homeostasis","OSTEOMICS","Inclusion Criteria:\n\n1. Patients with osteoarthritis undergoing total joint arthroplasty, osteotomy or arthrodesis of any joint (including hip, knee, shoulder, wrist, elbow, ankle).\n2. Patient with fractured neck of femurs undergoing hemiarthroplasty or total hip arthroplasty, or other internal fixation procedure.\n3. Patients undergoing acute low-velocity or fragility fracture fixation surgery.\n4. Patients aged between 18-110 years old with capacity to consent.\n\nSince deteriorating bone health including diseases like osteoporosis are primarily conditions of older age there is no practical upper age-limit. However, study involvement is limited by suitability for surgery which encompasses multiple factors considered on an individual case basis including age, frailty, comorbidities, baseline mobility, renal function and ability to consent (for instance due to dementia or delirium).\n\nWe note that our inclusion criteria is purposefully broad as we aim to deduce trends across a wide range of conditions and backgrounds.\n\nExclusion Criteria:\n\n1. Patients unable to provide informed consent.\n2. Patients with suspected\u002Festablished underlying malignancy.\n3. Patients with suspected\u002Festablished osteomyelitis.\n4. Patients with suspected\u002Festablished bloodborne disease\n5. Patients who are currently a subject of a clinical trial involving an investigational medicinal product.","ALL","18 Years","110 Years",{"count":161,"type":162},2000,"ESTIMATED","OBSERVATIONAL","Diseases of bone associated with ageing, including osteoporosis (OP) and osteoarthritis (OA), reduce bone mass, bone strength and joint integrity. Current non-surgical approaches are limited to pharmaceutical agents that are not disease modifying and have poor patient tolerability due to side effect profiles. Developing a fundamental understanding of cellular bone homeostasis, including how key cell types affect tissue health, and offering novel therapeutic targets for prevention of bone disease is therefore essential. This is the focus of OSTEOMICS.\n\nA number of factors have been linked to increased risk of bone disease, including genetic predisposition, diet, smoking, ageing, autoimmune disorders and endocrine disorders. In our study, we will recruit patients undergoing elective and non-elective orthopaedic surgery and obtain surgical bone waste for analysis. This will capture a cohort of patients with bone disorders like OP and OA, in addition to patients without overt clinical bone disease. We will study the relationship between the molecular biology of bone cells, bone structure, genetics (DNA) and environmental factors with the aim of identifying and validating novel therapeutic targets.\n\nWe will leverage modern single cell technologies to understand the diversity of cell types found in bone. These technologies have now led to the characterisation of virtually every tissue in the body, however bone and bone-adjacent tissues are massively underrepresented due to the anatomical location and underlying technical challenges. Early protocols to demineralise bone and perform single cell profiling have now been developed. We will systematically scale up these efforts to observe how genetic variation at the population level leads to alterations in bone structure and quality.\n\nOver the next 10 years, we will generate data to comprehensively characterise bone across health and disease, use machine learning to drive analysis, and experimentally validate hypotheses - which will ultimately contribute to developing the next generation of therapeutic agents.",[166,167,168,169,170],"Osteoporosis","Osteoarthritis","Bone Diseases","Bone Fracture","Bone Marrow Disease","2024-02-20",{"date":173,"type":174},"2024-02-23","ACTUAL",{"date":176,"type":174},"2023-01-12",{"date":178,"type":162},"2032-12",{"name":5,"class":6},8]