[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100534392":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":30,"locations":35,"responsibleParty":56,"collaborators":60,"id":79,"slug":80,"hasResults":81,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":85,"eligibilityCriteria":86,"healthyVolunteers":81,"sex":87,"minAge":88,"maxAge":89,"enrollmentInfo":90,"targetDuration":18,"studyType":93,"phases":94,"briefSummary":96,"conditions":97,"keywords":99,"overallStatus":38,"whyStopped":18,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":113},{"fullName":5,"class":6},"Chongqing Medical University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"68Ga-Pentixafor PET\u002FCT group","EXPERIMENTAL","Patients divided into 68Ga-Pentixafor PET\u002FCT group need to undergo 68Ga-Pentixafor PET\u002FCT examination and guide subsequent treatment based on the results",[13],"Diagnostic Test: 68Ga-Pentixafor PET\u002FCT",{"label":15,"type":16,"description":17,"interventionNames":18},"AVS group","NO_INTERVENTION","Patients divided into AVS group need to undergo AVS to guide subsequent treatment based on the results",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":18},"DIAGNOSTIC_TEST","68Ga-Pentixafor PET\u002FCT","The patients had a normal diet with no special preparation before 68Ga-Pentixafor PET\u002FCT imaging. The dosage of intravenously injected 68Ga-Pentixafor was calculated based on the patient's weight (1.85 MBq \\[0.05mCi\\]\u002Fkg). Local PET\u002FCT scanning of the upper abdomen was performed on a hybrid PET\u002FCT scanner at 10 minutes after the injection of the intravenous tracer, respectively.",[9],[26],{"name":27,"affiliation":28,"role":29},"Qifu Li, PhD","the Chongqing Primary Aldosteronism Study (CONPASS) Group","STUDY_CHAIR",[31],{"name":27,"role":32,"phone":33,"phoneExt":18,"email":34},"CONTACT","+86 023-89011552","liqifu@yeah.net",[36],{"facility":37,"status":38,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"The First Affilated Hospital of Chongqing Medical University","RECRUITING","Chongqing","Chongqing Municipality","400016","China","CN",{"type":45,"coordinates":46},"Point",[47,48],106.55771,29.56026,{"lat":48,"lon":47},[51,53],{"name":27,"role":32,"phone":52,"phoneExt":18,"email":34},"023-89011552",{"name":54,"role":32,"phone":52,"phoneExt":18,"email":55},"Ying Song, M.D.","shuiyunying@126.com",{"type":57,"investigatorFullName":58,"investigatorTitle":59,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"SPONSOR_INVESTIGATOR","Qifu Li","Primary investigator",[61,63,65,67,69,71,73,75,77],{"name":62,"class":6},"The Affiliated Hospital Of Southwest Medical University",{"name":64,"class":6},"West China Hospital",{"name":66,"class":6},"Tongji Hospital",{"name":68,"class":6},"The First Affiliated Hospital of Zhengzhou University",{"name":70,"class":6},"The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School",{"name":72,"class":6},"The Third Xiangya Hospital of Central South University",{"name":74,"class":6},"Second Affiliated Hospital, School of Medicine, Zhejiang University",{"name":76,"class":6},"Changzhi Medical College",{"name":78,"class":6},"Xiangya Hospital of Central South University","100534392","outcome-of-68ga-pentixafor-petct-versus-adrenal-vein-sampling-in-primary-aldosteronism-100534392",false,"NCT06238232","Outcome of 68Ga-Pentixafor PET\u002FCT Versus Adrenal Vein Sampling in Primary Aldosteronism","68Ga-Pentixafor PET\u002FCT Versus Adrenal Vein Sampling to Determine Treatment in Primary Aldosteronism: A Multicenter Randomized Clinical Trial","GAPA","Inclusion Criteria:\n\n(1)Getting the written informed consent (2)ARR ≥20 (pg\u002Fml)\u002F (μIU\u002Fml) or ARR ≥ 30(ng\u002FdL)\u002F(ng\u002Fml\u002Fhr) plus at least one positive PA confirmatory test (CCT, SSIT).\n\n(3)Patients who are willing to undergo surgery. (4)Patients with hypertension aged 18-70 years. (5)CT or MRI scan of the adrenal glands with nodule (≥1cm). Exclusion criteria\n\n1. Combined with autonomous cortisol secretion, cortisol after 1mg dexamethasone suppression test (DST) ≥50 nmol\u002Fl.\n2. PA patients who meet the by-passing AVS criteria \\[i.e., younger than 35 years old, spontaneous hypokalemia, adrenal CT indicated unilateral low-density adenoma (≥1cm), plasma aldosterone \\>300pg\u002Fml\\]\n3. Suspicion of familial hyperaldosteronism or Liddle syndrome. \\[i.e., age \\\u003C20 years, hypertension and hypokalemia, or with family history\\]\n4. Suspicion of pheochromocytoma or adrenal carcinoma.\n5. Patients with actively malignant tumor.\n6. Patients who have adrenalectomy history or with adrenocortical insufficiency.\n7. Long-term use of glucocorticoids.\n8. Pregnant or lactating women; with alcohol or drug abuse and mental disorders.\n9. Congestive heart failure with New York Heart Association (NYHA) Functional Classification III or IV; History of serious cardiovascular or cerebrovascular disease (angina, myocardial infarction or stroke) in the past 3 months; Severe anemia (Hb\\\u003C60g\u002FL); Serious liver dysfunction or chronic kidney disease aspartate aminotransferase (AST) or alanine transaminase (ALT) \\>3 times the upper limit of normal, or estimated glomerular filtration rate (eGFR) \\\u003C 30 ml\u002Fmin\u002F1.73 m2); Systemic Inflammatory Response Syndrome (SIRS); Uncontrolled diabetes (FBG≥13.3 mmol\u002FL); Obesity (BMI≥35 kg\u002Fm²) or Underweight (BMI≤18 kg\u002Fm²); Untreated aneurysm; Other comorbidity potentially interfering with treatment","ALL","18 Years","70 Years",{"count":91,"type":92},320,"ESTIMATED","INTERVENTIONAL",[95],"NA","To compare the 68Ga-Pentixafor PET\u002FCT and adrenal vein sampling on the long-term outcomes of primary aldosteronism (PA) patients with adrenal nodule (≥1cm)",[98],"Primary Aldosteronism",[100,101,22,102,103],"Primary aldosteronism;","Adrenal venous sampling","outcome","multicenter randomized","2024-04-27",{"date":106,"type":107},"2024-04-30","ACTUAL",{"date":109,"type":107},"2024-01-09",{"date":111,"type":92},"2027-12-31",{"name":58,"class":6},1]