[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100419452":3},{"organization":4,"armGroups":7,"interventions":47,"overallOfficials":57,"centralContacts":62,"locations":72,"responsibleParty":91,"collaborators":94,"id":100,"slug":101,"hasResults":102,"nctId":103,"briefTitle":104,"officialTitle":104,"acronym":10,"eligibilityCriteria":105,"healthyVolunteers":102,"sex":106,"minAge":10,"maxAge":10,"enrollmentInfo":107,"targetDuration":110,"studyType":111,"phases":10,"briefSummary":112,"conditions":113,"keywords":118,"overallStatus":75,"whyStopped":10,"lastUpdateSubmitDate":128,"lastUpdatePostDateStruct":129,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":136,"locationsCount":137},{"fullName":5,"class":6},"Copenhagen University Hospital at Herlev","OTHER",[8,15,19,23,27,31,35,39,43],{"label":9,"type":10,"description":11,"interventionNames":12},"Patient with osteoporosis - antiresorptive treatment > 4 years. Previous tooth extraction",null,"Patient with osteoporosis - antiresorptive treatment \\> 4 years who have had previous tooth extraction without development of MRONJ",[13,14],"Procedure: Dental implant surgery","Procedure: Prosthetic treatment",{"label":16,"type":10,"description":17,"interventionNames":18},"Patient with osteoporosis - antiresorptive treatment > 4 years. Previous resection","Patient with osteoporosis - antiresorptive treatment \\> 4 years who have lost teeth due to having previous osteonecrosis of the jaw which has been successfully surgically treated and healed for at least 3 months without recurrence",[13,14],{"label":20,"type":10,"description":21,"interventionNames":22},"Patient with osteoporosis - antiresorptive treatment > 4 years. Simultaneously with resection","Patient with osteoporosis - antiresorptive treatment \\> 4 years with ongoing osteonecrosis of the jaw to be surgically treated with block resection of the lower jaw and insertion of a titanium reconstruction plate. Simultaneous insertion of dental implants, or resection of the upper jaw where there is sufficient remaining bone volume to have implants inserted simultaneously (without bone augmentation)",[13,14],{"label":24,"type":10,"description":25,"interventionNames":26},"Patient with cancer - adjuvant dose antiresorptive treatment. Previous tooth extraction","Patient with cancer (breast, prostate or multiple myeloma) - adjuvant dose antiresorptive treatment who have had previous tooth extraction without development of MRONJ",[13,14],{"label":28,"type":10,"description":29,"interventionNames":30},"Patient with cancer - adjuvant dose antiresorptive treatment. Previous resection","Patient with cancer (breast, prostate or multiple myeloma) - adjuvant dose antiresorptive treatment who have lost teeth due to having previous osteonecrosis of the jaw which has been successfully surgically treated and healed for at least 3 months without recurrence",[13,14],{"label":32,"type":10,"description":33,"interventionNames":34},"Patient with cancer - adjuvant dose antiresorptive treatment. Simultaneously with resection","Patient with cancer (breast, prostate or multiple myeloma) - adjuvant dose antiresorptive treatment with ongoing osteonecrosis of the jaw to be surgically treated with block resection of the lower jaw and insertion of a titanium reconstruction plate. Simultaneous insertion of dental implants, or resection of the upper jaw where there is sufficient remaining bone volume to have implants inserted simultaneously (without bone augmentation)",[13,14],{"label":36,"type":10,"description":37,"interventionNames":38},"Cancer patient treated with high dose antiresorptive treatment. Previous tooth extraction","Cancer patient treated with high dose antiresorptive treatment who have had previous tooth extraction without development of MRONJ",[13,14],{"label":40,"type":10,"description":41,"interventionNames":42},"Cancer patient treated with high dose antiresorptive treatment. Previous resection","Cancer patient treated with high dose antiresorptive treatment who have lost teeth due to having previous osteonecrosis of the jaw which has been successfully surgically treated and healed for at least 3 months without recurrence",[13,14],{"label":44,"type":10,"description":45,"interventionNames":46},"Cancer patient treated with high dose antiresorptive treatment. Simultaneously with resection","Cancer patients (breast, prostate or multiple myeloma) treated with high dose antiresorptive treatment with ongoing osteonecrosis of the jaw to be surgically treated with block resection of the lower jaw and insertion of a titanium reconstruction plate. Simultaneous insertion of dental implants, or resection of the upper jaw where there is sufficient remaining bone volume to have implants inserted simultaneously (without bone augmentation)",[13,14],[48,53],{"type":49,"name":50,"description":51,"armGroupLabels":52,"otherNames":10},"PROCEDURE","Dental implant surgery","Dental surgery in patients treated with antiresorptive medication",[40,36,44,28,24,32,16,9,20],{"type":49,"name":54,"description":55,"armGroupLabels":56,"otherNames":10},"Prosthetic treatment","Prosthetic treatment and loading of the dental implants",[40,36,44,28,24,32,16,9,20],[58],{"name":59,"affiliation":60,"role":61},"Sanne Werner Moeller Andersen, DDS","Copenhagen University Hospital, Maxillofacial surgery","PRINCIPAL_INVESTIGATOR",[63,68],{"name":59,"role":64,"phone":65,"phoneExt":66,"email":67},"CONTACT","60625950","0045","sanne@w-madsen.dk",{"name":69,"role":64,"phone":70,"phoneExt":66,"email":71},"Thomas Kofod, PhD","35450626","thomas.steengaard@regionh.dk",[73],{"facility":74,"status":75,"city":76,"state":77,"zip":78,"country":79,"countryCode":80,"cosmosGeoPoint":81,"geoPoint":86,"contacts":87},"Copenhagen University Hospital, Maxillofacial Department","RECRUITING","Copenhagen","Danmark","2300","Denmark","DK",{"type":82,"coordinates":83},"Point",[84,85],12.56553,55.67594,{"lat":85,"lon":84},[88,89],{"name":59,"role":64,"phone":65,"phoneExt":66,"email":67},{"name":90,"role":64,"phone":70,"phoneExt":66,"email":71},"Thomas Steengaard Kofod, PhD",{"type":61,"investigatorFullName":92,"investigatorTitle":93,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Sanne Werner Moeller Andersen","Oral and Maxillofacial Surgeon",[95,98],{"name":96,"class":97},"Amgen","INDUSTRY",{"name":99,"class":97},"Institut Straumann AG","100419452","outcome-of-dental-implant-therapy-in-patients-treated-with-antiresorptive-medication-100419452",false,"NCT04741906","Outcome of Dental Implant Therapy in Patients Treated With Antiresorptive Medication","Inclusion Criteria:\n\n* Patient with cancer or osteoporosis, treated with antiresorptive treatment.\n* The patients should have sufficient compliance, this includes willingness to have the planned assessments\n* The patient should have an expected life span at enrollment of at least 2 years.\n* The local bone quality and quantity should be sufficient for implant insertion without bone augmentation and is classified according to the classification by Cawood \\& Howell 1988.\n\nExclusion Criteria:\n\n* \\> 10 cigarettes daily\n* HbA1c \\> 53 mmol\u002Fmol\n* Poor oral hygiene\n* Poor general condition: ECOG score 3 or 4.\n* Poor prognosis: Expected survival \\\u003C2 year is an exclusion cause.\n* Presence of metastases of the liver brain.\n* Poor local jaw bone quality acc. to Cawood classification stage 3 or 4.\n* Unwillingness to comply with the planned assessments and recordings","ALL",{"count":108,"type":109},225,"ESTIMATED","2 Years","OBSERVATIONAL","Aim of the study is to examine the feasibility of dental implant insertion in patients receiving high, adjuvant and low dose \\> 4 years.",[114,115,116,117],"Missing Teeth","Implants","Cancer","Osteoporosis",[119,120,121,122,123,124,125,126,127],"Dental implants","High dose antiresorptive medication","Rehabilitation","Denosumab","Bisphosphonate","Oral rehabilitation","Adjuvant dose antiresorptive medication","Low dose antiresorptive medication","Bone modifying agents","2024-08-20",{"date":130,"type":131},"2024-08-21","ACTUAL",{"date":133,"type":131},"2017-08-01",{"date":135,"type":109},"2025-12-31",{"name":5,"class":6},1]