[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100545201":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":40,"centralContacts":45,"locations":49,"responsibleParty":55,"collaborators":57,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":66,"eligibilityCriteria":67,"healthyVolunteers":68,"sex":69,"minAge":70,"maxAge":49,"enrollmentInfo":71,"targetDuration":49,"studyType":74,"phases":75,"briefSummary":77,"conditions":78,"keywords":49,"overallStatus":81,"whyStopped":49,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":49},{"fullName":5,"class":6},"King's College London","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Selective Caries Removal","EXPERIMENTAL","This process will be conducted under an operating microscope to ensure precise removal of carious dentin on cavity walls. Only disorganized carious dentin on the cavity floor will be removed using hand instruments in the control group which is SCR group",[13,14],"Procedure: Selective Caries Removal (No Pulp Exposure)","Procedure: Partial Pulpotomy (Pulp Exposed)",{"label":16,"type":10,"description":17,"interventionNames":18},"Non selective caries removal","On the other hand, removal of carious dentin on cavity floor will be completely up to hard sound dentine in NSCR group.",[19,14],"Procedure: Non-Selective Caries Removal (No Pulp exposure)",[21,28,34],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","Selective Caries Removal (No Pulp Exposure)","Caries excavation technique where clinician leaves carious tissue so close to pulp",[9],[27],"SCR",{"type":22,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"Non-Selective Caries Removal (No Pulp exposure)","Complete caries removal even in areas so close to pulp",[16],[33],"NSCR",{"type":22,"name":35,"description":36,"armGroupLabels":37,"otherNames":38},"Partial Pulpotomy (Pulp Exposed)","In caes of Pulp exposure Amputation of inflamed coronal pulp and capping of remaining vital tissue",[16,9],[39],"Miniature Pulpotomy",[41],{"name":42,"affiliation":43,"role":44},"Francesco Mannoci, Professor","professor of endodontics","PRINCIPAL_INVESTIGATOR",[46,51],{"name":42,"role":47,"phone":48,"phoneExt":49,"email":50},"CONTACT","02011881573",null,"francesco.mannocci@kcl.ac.uk",{"name":52,"role":47,"phone":53,"phoneExt":49,"email":54},"Sakha Z Abdelkhader, PhD student","07818723293","sakha.abdelkhader@kcl.ac.uk",{"type":56,"investigatorFullName":49,"investigatorTitle":49,"investigatorAffiliation":49,"oldNameTitle":49,"oldOrganization":49},"SPONSOR",[58],{"name":59,"class":6},"Guy's and St Thomas' NHS Foundation Trust","100545201","outcome-of-selective--nonselective-caries-removal-in-permanent-teeth-100545201",false,"NCT06378814","Outcome of Selective & Nonselective Caries Removal in Permanent Teeth","Randomized Clinical Trial of Treatment Outcomes of Selective Versus Nonselective Caries Removal in Deep Carious Lesions in Permanent Teeth.","RCT-SNCR","Inclusion Criteria:\n\n1. Dental patients from routine dental care at ADC (Acute Dental Care) clinics, both undergraduate and postgraduate dental clinics in Guy's Hospital.\n2. Both male and female individuals aged 18 years and older.\n3. Capable of providing informed consent.\n4. Generally, in good overall health from a medical standpoint.\n5. Possess at least one molar or premolar tooth exhibiting a clinically significant deep carious lesion, with or without carious pulp exposure.\n6. Displaying signs and symptoms indicative of a normal pulp or reversible pulpitis.\n7. positive response to the cold test (refrigerated gas).\n8. Absence of spontaneous pain.\n9. Absence of periapical lesions, as determined by routine radiographic examination\n\nExclusion Criteria:\n\n1. Presence of fistulas or swelling.\n2. Involvement of anterior teeth.\n3. Evidence of external or internal root resorption.\n4. Multiple teeth with carious lesions within the same quadrant.\n5. Pregnancy in women.\n6. Patients under the age of 18.\n7. Individuals unable to provide informed consent.\n8. Patients who have received antibiotics in the preceding month.\n9. Immunocompromised patients.\n10. Teeth with tooth surface loss resulting from traumatic parafunctional habits or teeth displaying craze lines.\n11. Caries located beneath the gingival margin .\n12. Teeth affected by periodontal issues, characterized by bone loss or severe gingival recession.\n13. Teeth with pulp exposure where operators cannot achieve hemostasis after applying a cotton pellet soaked with 2.5% sodium hypochlorite (NaOCl) for three cycles, with each cycle consisting of a 2-minute application of NaOCl.\n14. People with difficulty to understand the clinical trial concept, procedure and details including language barrier.\n15. participants who are involved in other research at the same period of our study.",true,"ALL","18 Years",{"count":72,"type":73},168,"ESTIMATED","INTERVENTIONAL",[76],"NA","Patients presenting with deep decay within permanent teeth presents a common clinical challenge to dentists. The aim of this trial is to compare the success rate of the non-selective caries removal (NSCR) and selective caries removal (SCR) in managing deep caries, as both methods are commonly used in clinical practice.\n\nThis study will be a randomized controlled trial, with participants divided into two groups: NSCR group and SCR group. Participants of deep caries lesions (reaching more than two-thirds of dentin on periapical radiographs) Both groups will undergo either NSCR or SCR, followed by Partial Pulpotomy (PP) in cases with pulp exposure. Success rates will be assessed at follow-up visits scheduled 1, 3, and 5 years radiographs will be used to assess for pulp health(vitality).\n\nThe success rate of the two categories will be assessed using a scale that includes factors such as tooth vitality, caries recurrence, and clinical signs of pulpitis. The scale will be applied at follow-up visits. The trial will be conducted in post-graduate dental clinics at Guy's hospital.\n\nDeep caries in permanent teeth is a common clinical problem that can lead to pulp exposure and subsequent restorative challenges. The aim of this study is to provide evidence-based guidance for clinicians in managing deep caries lesions, as both NSCR and SCR are commonly used in clinical practice. The results of this study will help clinicians to make informed decisions when choosing the appropriate treatment approach for their patients.\n\nIn conclusion, this trial aims to compare the success rate of NSCR and SCR in managing deep caries lesions in permanent teeth, as both methods are commonly used in clinical practice. The results of this study will provide valuable insights into the effectiveness of these two treatment approaches and will help clinicians to make informed decisions when choosing the appropriate treatment approaches.",[79,80],"Deep Caries","Carious Exposure of Pulp","NOT_YET_RECRUITING","2024-04-25",{"date":84,"type":85},"2024-04-29","ACTUAL",{"date":87,"type":73},"2024-05-01",{"date":89,"type":73},"2030-04-30",{"name":5,"class":6}]