[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100634933":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":7,"centralContacts":8,"locations":14,"responsibleParty":29,"collaborators":7,"id":31,"slug":32,"hasResults":33,"nctId":34,"briefTitle":35,"officialTitle":36,"acronym":7,"eligibilityCriteria":37,"healthyVolunteers":33,"sex":38,"minAge":39,"maxAge":40,"enrollmentInfo":41,"targetDuration":7,"studyType":44,"phases":7,"briefSummary":45,"conditions":46,"keywords":7,"overallStatus":16,"whyStopped":7,"lastUpdateSubmitDate":49,"lastUpdatePostDateStruct":50,"startDateStruct":53,"completionDateStruct":55,"leadSponsor":57,"locationsCount":58},{"fullName":5,"class":6},"IRCCS Azienda Ospedaliero-Universitaria di Bologna","OTHER",null,[9],{"name":10,"role":11,"phone":12,"phoneExt":7,"email":13},"Diego Raimondo, MD","CONTACT","+393290636618","die.raimondo@gmail.com",[15],{"facility":5,"status":16,"city":17,"state":17,"zip":18,"country":19,"countryCode":20,"cosmosGeoPoint":21,"geoPoint":26,"contacts":27},"RECRUITING","Bologna","40138","Italy","IT",{"type":22,"coordinates":23},"Point",[24,25],11.33875,44.49381,{"lat":25,"lon":24},[28],{"name":10,"role":11,"phone":12,"phoneExt":7,"email":13},{"type":30,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR","100634933","ovarian-tissue-cryopreservation-combined-with-oocyte-cryopreservation-versus-oocyte-cryopreservation-alone-100634933",false,"NCT07546123","Ovarian Tissue Cryopreservation Combined With Oocyte Cryopreservation Versus Oocyte Cryopreservation Alone","Ovarian Tissue Cryopreservation Combined With Oocyte Cryopreservation Versus Oocyte Cryopreservation Alone: an Observational Study in Oncology Patients","Inclusion Criteria:\n\n* Patient with oncological disease eligible for potentially gonadotoxic therapy\n* BMI ≥ 17.5 kg\u002Fm² and ≤ 32 kg\u002Fm²\n* Age ≥ 18 years and ≤ 46 years\n\nExclusion Criteria:\n\n* Hypersensitivity to one or more of the active substances used during ovarian stimulation treatment\n* Positive for HBV, HCV, HIV, or Treponema pallidum\n* Lack of oncological clearance","FEMALE","18 Years","46 Years",{"count":42,"type":43},127,"ESTIMATED","OBSERVATIONAL","Fertility preservation is a crucial aspect of care for oncological patients undergoing gonadotoxic treatments such as chemotherapy, radiotherapy, or surgery, which can significantly reduce ovarian reserve and cause infertility or premature menopause. Among available techniques, oocyte cryopreservation is well-established with high survival rates but requires controlled ovarian stimulation and may not be suitable for prepubertal patients or those needing urgent cancer therapy. Ovarian tissue cryopreservation offers advantages by preserving a larger number of primordial follicles, can be performed anytime in the menstrual cycle regardless of age, and also helps restore ovarian endocrine function.\n\nCombining ovarian tissue cryopreservation followed by oocyte cryopreservation may maximize fertility preservation by safeguarding more follicles and ensuring availability of mature oocytes.\n\nThis study will collect data from two patient groups:\n\nGroup 1: patients undergoing ovarian tissue cryopreservation followed by oocyte cryopreservation (combined treatment)\n\nGroup 2: patients undergoing oocyte cryopreservation alone.\n\nGroup assignment is based on planned gonadotoxic therapy and available time before treatment initiation, according to clinical practice.\n\nThe study aims to compare the number of oocytes retrieved per ovarian stimulation cycle between the two groups, along with the oocyte retrieval rate (number of oocytes retrieved\u002Fnumber of aspirated follicles), number of mature oocytes (metaphase II), incidence of moderate ovarian hyperstimulation syndrome within 7 days post-retrieval, and correlations between serum estradiol and luteinizing hormone levels on trigger day and oocyte yield.\n\nApproximately 127 patients aged 18 to 46 will be consecutively enrolled at the UO Gynecology and Human Reproduction Pathophysiology, IRCCS AOUBO Policlinico di Sant'Orsola. This is a cross-sectional, single-center, observational study with both retrospective and prospective enrollment. The retrospective period considered is from January 1, 2022, to the study start date. The study duration is 4 years and 3 months.",[47,48],"Oncological Disease","Fertility Preservation","2026-04-20",{"date":51,"type":52},"2026-04-22","ACTUAL",{"date":54,"type":52},"2025-08-25",{"date":56,"type":43},"2029-09",{"name":5,"class":6},1]