[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100616319":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":30,"centralContacts":34,"locations":43,"responsibleParty":57,"collaborators":59,"id":65,"slug":66,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":25,"eligibilityCriteria":71,"healthyVolunteers":67,"sex":72,"minAge":73,"maxAge":25,"enrollmentInfo":74,"targetDuration":25,"studyType":77,"phases":78,"briefSummary":80,"conditions":81,"keywords":83,"overallStatus":86,"whyStopped":25,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"UNC Lineberger Comprehensive Cancer Center","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Genetic Counselor participants","EXPERIMENTAL","Participants who are practicing genetic counselor at a medical institution.",[13],"Behavioral: Let's Talk Genetics Providers",{"label":15,"type":10,"description":16,"interventionNames":17},"Patient participants","Participants who are with diagnosis of Lynch syndrome.",[18],"Behavioral: Let's Talk Patients",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"BEHAVIORAL","Let's Talk Genetics Providers","Providers will complete a brief pre-intervention survey and a short training on the Let's Talk tool. They will then help recruit eligible patients from genetics clinics who need cascade screening for Lynch syndrome. After the intervention, providers will complete post-intervention surveys and interviews.",[9],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Let's Talk Patients","Patients will complete a brief pre-intervention survey and receive access to the online Let's Talk toolkit for two months. The toolkit addresses key barriers to cascade screening for Lynch syndrome by building knowledge, confidence, and communication skills through simple, evidence-based activities. After two months, patients will complete a post-intervention survey and participate in a qualitative interview.",[15],[31],{"name":32,"affiliation":5,"role":33},"Megan Roberts, PhD","PRINCIPAL_INVESTIGATOR",[35,40],{"name":36,"role":37,"phone":38,"phoneExt":25,"email":39},"Becca Bosch","CONTACT","919-984-0000","Rebecca_Bosch@med.unc.edu",{"name":41,"role":37,"phone":38,"phoneExt":25,"email":42},"Cason E Whitcomb","Cason_Whitcomb@med.unc.edu",[44],{"facility":45,"status":25,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":25},"University of North Carolina at Chapel Hill","Chapel Hill","North Carolina","27599","United States","US",{"type":52,"coordinates":53},"Point",[54,55],-79.05584,35.9132,{"lat":55,"lon":54},{"type":58,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR",[60,63],{"name":61,"class":62},"National Institutes of Health (NIH)","NIH",{"name":64,"class":62},"National Human Genome Research Institute (NHGRI)","100616319","overcoming-barriers-to-uptake-of-cascade-screening-100616319",false,"NCT07304063","Overcoming Barriers to Uptake of Cascade Screening","Let's Talk: Overcoming Barriers to Uptake of Cascade Screening Through a Stakeholder-informed Online Intervention","Inclusion Criteria for Patients\n\n* Written informed consent obtained to participate in the study.\n* Subject is willing and able to comply with study procedures based on the judgement of the investigator or protocol designee.\n* Age ≥ 18 years at the time of consent.\n* Written informed consent obtained to participate in the study.\n* Self-reported Lynch syndrome diagnosis.\n\nInclusion Criteria for Genetic Counselor\n\n* Written informed consent obtained to participate in the study.\n* Subject is willing and able to comply with study procedures based on the judgement of the investigator or protocol designee.\n* Age ≥ 18 years at the time of consent.\n* Written informed consent obtained to participate in the study.\n* Self-reported employment as a practicing genetic counselor at a medical institution.\n\nExclusion Criteria for Patients\n\n* The patient has already notified all relatives about their diagnosis with Lynch syndrome.\n\nExclusion Criteria for Genetic Counselor\n\n* Genetic Counselor is not employed.","ALL","18 Years",{"count":75,"type":76},20,"ESTIMATED","INTERVENTIONAL",[79],"NA","Lynch syndrome is a genetic condition that increases cancer risk. The public health impact of genetic testing for disease prevention hinges on cascade screening, which is the systematic identification and testing of blood relatives after a family member has been diagnosed with a genetic condition. Despite its importance in disease prevention, only half of first-degree relatives of individuals with Lynch syndrome undergo cascade screening. To address this gap, the study will pilot test an online version of Let's Talk, a novel intervention designed to support and promote cascade screening. This intervention tool is designed to support and encourage more family members to get screened. The purpose of this study aim is to assess the feasibility of the online Let's Talk tool in clinical use by examining implementation and effectiveness outcomes related to the use of the planning tool across three clinics at a large academic-affiliated medical center with patients (n=15) seen by one of five genetic counselors (n=5).",[82],"Lynch Syndrome",[84,85],"Screening","cascade screening","NOT_YET_RECRUITING","2026-06-22",{"date":89,"type":90},"2026-06-23","ACTUAL",{"date":92,"type":76},"2026-07",{"date":94,"type":76},"2026-10",{"name":5,"class":6},1]