[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100530967":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":28,"centralContacts":32,"locations":44,"responsibleParty":67,"collaborators":69,"id":72,"slug":73,"hasResults":74,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":78,"eligibilityCriteria":79,"healthyVolunteers":80,"sex":81,"minAge":82,"maxAge":83,"enrollmentInfo":84,"targetDuration":24,"studyType":87,"phases":88,"briefSummary":90,"conditions":91,"keywords":24,"overallStatus":47,"whyStopped":24,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":102},{"fullName":5,"class":6},"German Diabetes Center","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"High-fat overnutrition","ACTIVE_COMPARATOR","Lipid overnutrition: 40% higher lipid consumption per day than required over three weeks.",[13],"Behavioral: High-fat overnutrition",{"label":15,"type":10,"description":16,"interventionNames":17},"Normocaloric macronutrient-balanced nutrition","Normocaloric, macronutrient-balanced nutrition per day over three weeks",[18],"Behavioral: Normocaloric macronutrient-balanced nutrition",[20,25],{"type":21,"name":9,"description":22,"armGroupLabels":23,"otherNames":24},"BEHAVIORAL","Overnutrition: 40% higher lipid consumption per day than required",[9],null,{"type":21,"name":15,"description":26,"armGroupLabels":27,"otherNames":24},"Normocaloric, macronutrient-balanced nutrition:\n\nCalories requirement for weight maintenance \\[(kcal\u002Fd) 55% carbohydrates, 15% proteins, 30% fat\\]",[15],[29],{"name":30,"affiliation":5,"role":31},"Michael Roden, Prof., MD","STUDY_DIRECTOR",[33,39],{"name":34,"role":35,"phone":36,"phoneExt":37,"email":38},"Theresia Sarabhai, MD","CONTACT","0173-9473478","DDZ","theresia.sarabhai@ddz.de",{"name":40,"role":35,"phone":41,"phoneExt":42,"email":43},"Sabine Kahl, MD","0221-3382-","698","sabine.kahl@ddz.de",[45],{"facility":46,"status":47,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"Georgia Xourafa","RECRUITING","Düsseldorf","North Rhine-Westphalia","40225","Germany","DE",{"type":54,"coordinates":55},"Point",[56,57],6.77927,51.22319,{"lat":57,"lon":56},[60,64],{"name":61,"role":35,"phone":62,"phoneExt":24,"email":63},"Georgia Xourafa, MD","+492113382426","georgia.xourafa@ddz.de",{"name":34,"role":35,"phone":65,"phoneExt":24,"email":66},"0211-3382-0","theresia.Sarabhai@ddz.de",{"type":68,"investigatorFullName":24,"investigatorTitle":24,"investigatorAffiliation":24,"oldNameTitle":24,"oldOrganization":24},"SPONSOR",[70],{"name":71,"class":6},"Yale University","100530967","overfeeding-induced-fat-tissue-stimulation-100530967",false,"NCT06193668","Overfeeding Induced Fat-tissue Stimulation","Short-term High-fat Overnutrition Induces Insulin Resistance in White Adipose Tissue","OVID_FASTI","Inclusion Criteria:\n\n* Age between 18 and 40 years\n* BMI \\\u003C 29 kg\u002Fm2\n* Sport inactive (\\\u003C1x \u002Fweek)\n* Capacity to consent\n\nExclusion Criteria:\n\n* Diabetes mellitus disease\n* Acute coronary heart syndrome (myocardial infarction, unstable angina pectoris, stroke or transient ischemic attack in the last 3 months before study participation)\n* Acute infectious disease\n* Taking blood glucose-lowering drugs\n* Diseases or drugs affecting the immune system and allergies to drugs used in the study\n* Drugs with potential metabolic effects\n* Chronic liver disease (hepatitis, gallbladder disease, elevated liver enzymes (ALT \\> 300 U\u002FL))\n* Chronic inflammatory bowel diseases\n* Rheumatic diseases\n* Hyper- or hypothyroidism of the thyroid gland\n* Renal insufficiency, administration of iodine-containing contrast media in the last 2 days\n* Chronic lung diseases\n* cancerous diseases\n* Addictive diseases, psychiatric diseases\n* Pregnancy, breastfeeding\n* Shift workers\n* Anemia (Hb \\\u003C12 g\u002Fdl)\n* Disorders of hemostasis\n* Regular use of antithrombotic drugs\n* Alcohol consumption, smoking\n* Conditions that do not permit an MRI examination",true,"ALL","18 Years","40 Years",{"count":85,"type":86},32,"ESTIMATED","INTERVENTIONAL",[89],"NA","Type 2 diabetes is the most common metabolic disease worldwide, characterized by hyperglycemia, decreased whole body insulin sensitivity, and white adipose tissue (WAT) dysfunction. A key factor in its development is chronic overnutrition, usually with a high-fat diet (HFD), leading to disturbances of glucose and lipid metabolism. However, the mechanism of short-term HFD-induced tissue-specific insulin resistance remains poorly understood. This project aims to further unravel the underlying mechanisms of short-term HFD overnutrition-mediated WAT insulin resistance. The model described here corresponds to a randomized, single- blinded parallel-grouped trial, consisting of two interventions: a macronutrient-balanced diet and or a hypercaloric diet over three weeks in order to investigate differences in interorgan fatty acid and glucose metabolism between the studied groups. Based on recent studies, the hypothesis is that 21-day hypercaloric HFD induces WAT insulin resistance via a diacylglycerol, novel protein kinase C-insulin receptor signaling model in both fasting and insulin-stimulated states.",[92],"Lipid-induced Insulin Resistance","2024-02-29",{"date":95,"type":96},"2024-03-01","ACTUAL",{"date":98,"type":96},"2024-01-31",{"date":100,"type":86},"2030-12-31",{"name":5,"class":6},1]