[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100289072":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":33,"centralContacts":37,"locations":45,"responsibleParty":82,"collaborators":42,"id":85,"slug":86,"hasResults":87,"nctId":88,"briefTitle":89,"officialTitle":90,"acronym":42,"eligibilityCriteria":91,"healthyVolunteers":87,"sex":92,"minAge":93,"maxAge":94,"enrollmentInfo":95,"targetDuration":42,"studyType":98,"phases":99,"briefSummary":101,"conditions":102,"keywords":107,"overallStatus":48,"whyStopped":42,"lastUpdateSubmitDate":112,"lastUpdatePostDateStruct":113,"startDateStruct":116,"completionDateStruct":118,"leadSponsor":120,"locationsCount":121},{"fullName":5,"class":6},"Vanderbilt University Medical Center","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Heat Stress","EXPERIMENTAL","Passive heat-stress using a commercial heating pad applied on the trunk",[13],"Other: Heating pad",{"label":15,"type":16,"description":17,"interventionNames":18},"Control (Non-heating)","SHAM_COMPARATOR","Commercial heating pad applied on the trunk but turned off",[19],"Other: Sham control",[21,27],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"Heating pad","Heat stress applied on the trunk for up to 8 hours",[9],[26],"Local heat stress",{"type":6,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"Sham control","heating pad turned off applied on the trunk for up to 8 hours",[15],[32],"control",[34],{"name":35,"affiliation":5,"role":36},"Italo Biaggioni, MD","PRINCIPAL_INVESTIGATOR",[38,44],{"name":39,"role":40,"phone":41,"phoneExt":42,"email":43},"Bonnie K Black, RN","CONTACT","615-343-6862",null,"autonomics@vumc.org",{"name":35,"role":40,"phone":42,"phoneExt":42,"email":43},[46],{"facility":47,"status":48,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"Autonomic Dysfunction Center\u002F Vanderbilt University Medical Center","RECRUITING","Nashville","Tennessee","37232","United States","US",{"type":55,"coordinates":56},"Point",[57,58],-86.78444,36.16589,{"lat":58,"lon":57},[61,64,66,68,70,72,73,75,77,79,81],{"name":62,"role":40,"phone":63,"phoneExt":42,"email":43},"Emily C Smith, RN","615.875.1516",{"name":39,"role":40,"phone":65,"phoneExt":42,"email":43},"615-322-3304",{"name":39,"role":67,"phone":42,"phoneExt":42,"email":42},"SUB_INVESTIGATOR",{"name":69,"role":67,"phone":42,"phoneExt":42,"email":42},"Luis E Okamoto, MD",{"name":71,"role":67,"phone":42,"phoneExt":42,"email":42},"David Robertson, MD",{"name":35,"role":36,"phone":42,"phoneExt":42,"email":42},{"name":74,"role":67,"phone":42,"phoneExt":42,"email":42},"Alfredo Gamboa, MD",{"name":76,"role":67,"phone":42,"phoneExt":42,"email":42},"Cyndya A Shibao, MD",{"name":78,"role":67,"phone":42,"phoneExt":42,"email":42},"Andre Diedrich, MD, PhD",{"name":80,"role":67,"phone":42,"phoneExt":42,"email":42},"jorge Celedonio, MD",{"name":62,"role":67,"phone":42,"phoneExt":42,"email":42},{"type":36,"investigatorFullName":83,"investigatorTitle":84,"investigatorAffiliation":5,"oldNameTitle":42,"oldOrganization":42},"Italo Biaggioni","Professor of Medicine and Pharmacology","100289072","overnight-trials-with-heat-stress-in-autonomic-failure-patients-with-supine-hypertension-100289072",false,"NCT03042988","Overnight Trials With Heat Stress in Autonomic Failure Patients With Supine Hypertension","Overnight Trials to Compare the Effects of Controlled Heat Stress Versus Sham Control on Nocturnal Supine Hypertension in Autonomic Failure Patients","Inclusion Criteria:\n\n* Male and female patients, between 18-80 yrs., with primary autonomic failure (Parkinson Disease, Multiple System Atrophy, and Pure Autonomic Failure) and supine hypertension. Supine hypertension will be defined as SBP≥150 mmHg.\n* Patients able and willing to provide informed consent.\n\nExclusion Criteria:\n\n* Pregnancy\n* Significant cardiac, renal or hepatic illness, or with contraindications to administration of pressor agents or with other factors, which in the investigator's opinion would prevent the subject from completing the protocol including clinically significant abnormalities in clinical, mental or laboratory testing.","ALL","18 Years","80 Years",{"count":96,"type":97},20,"ESTIMATED","INTERVENTIONAL",[100],"NA","Patients with autonomic failure are characterized by disabling orthostatic hypotension (low blood pressure on standing), and at least half of them also have high blood pressure while lying down (supine hypertension). Exposure to heat, such as in hot environments, often worsens their orthostatic hypotension. The causes of this are not fully understood. The purpose of this study is to evaluate whether applying local heat over the abdomen of patients with autonomic failure and supine hypertension during the night would decrease their nocturnal high blood pressure while lying down. This will help us better understand the mechanisms underlying this phenomenon, and may be of use in the treatment of supine hypertension.",[103,104,105,106],"Hypertension","Pure Autonomic Failure","Multiple System Atrophy","Autonomic Failure",[108,109,110,111],"supine hypertension","autonomic failure","heat stress","orthostatic hypotension","2026-01-14",{"date":114,"type":115},"2026-01-16","ACTUAL",{"date":117,"type":115},"2017-01-30",{"date":119,"type":97},"2026-12-30",{"name":5,"class":6},1]