[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100588655":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":22,"centralContacts":22,"locations":25,"responsibleParty":47,"collaborators":49,"id":53,"slug":54,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":57,"acronym":22,"eligibilityCriteria":58,"healthyVolunteers":59,"sex":60,"minAge":61,"maxAge":62,"enrollmentInfo":63,"targetDuration":22,"studyType":66,"phases":67,"briefSummary":69,"conditions":70,"keywords":73,"overallStatus":28,"whyStopped":22,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":85},{"fullName":5,"class":6},"University of Chicago","OTHER",[8,13],{"label":9,"type":6,"description":10,"interventionNames":11},"Kidney stone formers","12 stone-forming subjects will be enrolled in this arm.",[12],"Other: Kidney stone formers",{"label":14,"type":6,"description":15,"interventionNames":16},"Control cohort","12 non-stone-forming subjects will be enrolled in this arm.",[17],"Other: Control cohort",[19,23],{"type":6,"name":9,"description":20,"armGroupLabels":21,"otherNames":22},"Consuming a special drink (potassium citrate) during an all-day visit to the University of Chicago research clinic\n\nSubjects in both groups will be asked to partake in the same activities, as follows: The day before presenting to the research clinic, subjects will collect urine at home. Subjects will then come to the research clinic at the University of Chicago in Hyde Park, where they will spend most of the day. We will give them a special liquid that contains potassium citrate. After this, we will collect urine and blood samples throughout the day. While at the clinic, subjects will also receive a boxed lunch at the end of the visit.",[9],null,{"type":6,"name":14,"description":20,"armGroupLabels":24,"otherNames":22},[14],[26],{"facility":27,"status":28,"city":29,"state":30,"zip":31,"country":32,"countryCode":33,"cosmosGeoPoint":34,"geoPoint":39,"contacts":40},"University of Chicago Medical Center","RECRUITING","Chicago","Illinois","60637","United States","US",{"type":35,"coordinates":36},"Point",[37,38],-87.65005,41.85003,{"lat":38,"lon":37},[41],{"name":42,"role":43,"phone":44,"phoneExt":45,"email":46},"Megan Prochaska, MD","CONTACT","773-702-1000","45488","mprocha2@medicine.bsd.uchicago.edu",{"type":48,"investigatorFullName":22,"investigatorTitle":22,"investigatorAffiliation":22,"oldNameTitle":22,"oldOrganization":22},"SPONSOR",[50],{"name":51,"class":52},"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","NIH","100588655","oxalate-and-citrate-in-humans---response-to-citrate-100588655",false,"NCT06944223","Oxalate and Citrate in Humans - Response to Citrate","Inclusion Criteria:\n\nStone formers (SF):\n\n* Age 18-70\n* History of at least one calcium-based kidney stone\n\nNon-stone formers (NSF):\n\n* Age 18-70\n* No history of kidney stone\n* 24-hour urine oxalate within laboratory normal range (\\\u003C50 mg\u002Fday)\n\nExclusion Criteria:\n\nHistory of primarily uric acid, cysteine, or struvite stones\n\nHistory of severe acid-base abnormality, very low (less than 100 mg\u002Fday) or very high (greater than 1500 mg\u002Fday) urine citrate\n\nAny controls or stone former (SF) participants who cannot stop diuretic medication or alkali supplementation for the course of the study period\n\nChronic kidney disease (glomerular filtration rate \\\u003C75 milliliters per minute per 1.73 square meters \\[mL\u002Fmin\u002F1.73 m²\\])\n\nNon-stone formers (NSF) and stone formers (SF) with extreme levels of urine citrate will be excluded from this small initial study to reduce heterogeneity and remove focus from the extremes of citrate levels.",true,"ALL","18 Years","70 Years",{"count":64,"type":65},24,"ESTIMATED","INTERVENTIONAL",[68],"NA","This is a single-center study that aims to learn more about how two compounds found in food, oxalate and citrate, interact in the body and may influence a person's chances of forming kidney stones. The study will examine changes in urinary oxalate and citrate levels after participants consume potassium citrate.",[71,72],"Kidney Stone","Healthy",[74,75],"kidney stone","kidney stones","2025-12-15",{"date":78,"type":79},"2025-12-16","ACTUAL",{"date":81,"type":79},"2025-10-01",{"date":83,"type":65},"2027-06-01",{"name":5,"class":6},1]