[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100470972":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":10,"centralContacts":19,"locations":25,"responsibleParty":45,"collaborators":10,"id":48,"slug":49,"hasResults":50,"nctId":51,"briefTitle":52,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":50,"sex":55,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":10,"studyType":61,"phases":10,"briefSummary":62,"conditions":63,"keywords":10,"overallStatus":28,"whyStopped":10,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":75},{"fullName":5,"class":6},"Ohio State University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Oxygen exposures",null,"mechanically ventilated patients with atleast 1.5 hours of FiO2 exposure of 50% or more",[13],"Other: oxygen",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":10},"oxygen","oxygen exposure of more than 50% for 1.5 hours",[9],[20],{"name":21,"role":22,"phone":23,"phoneExt":10,"email":24},"Sarah Karow","CONTACT","6142920031","sarah.karow@osumc.edu",[26],{"facility":27,"status":28,"city":29,"state":30,"zip":31,"country":32,"countryCode":33,"cosmosGeoPoint":34,"geoPoint":39,"contacts":40},"Ohio State University Medical Center","RECRUITING","Columbus","Ohio","43210","United States","US",{"type":35,"coordinates":36},"Point",[37,38],-82.99879,39.96118,{"lat":38,"lon":37},[41],{"name":42,"role":22,"phone":43,"phoneExt":10,"email":44},"Sonal Pannu","507-226-1636","sonal.pannu@osumc.edu",{"type":46,"investigatorFullName":42,"investigatorTitle":47,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Principal Investigator","100470972","oxidative-lipidomic-biomarkers-during-mechanical-ventilation-in-critically-ill-patients-oxy-bal-100470972",false,"NCT05412810","Oxidative Lipidomic Biomarkers During Mechanical Ventilation in Critically Ill Patients (OXY-BAL).","OXY-BAL","Inclusion Criteria:\n\n• Adults age =\\> 18 and needing Mechanical ventilation in Intensive Care unit expected atleast for 48 hours\n\nExclusion Criteria:\n\n* 1.Mechanical ventilation, only needed for performing procedures- bronchoscopy, esophagogastroduodenoscopy, colonoscopy, or others\n* 2)Chronic respiratory failure prior to admission;\n* 3)Hemoptysis or diffuse alveolar hemorrhage\n* 4)Medication use such as N acetyl cysteine; aspirin, fish oil supplements.\n* 5)Primary team prohibits bronchoscopy for a specific clinical indication or safety;","ALL","18 Years","110 Years",{"count":59,"type":60},200,"ESTIMATED","OBSERVATIONAL","The aim of this study is to identify and determine the levels of oxidized lipids and lipid mediators following exposure to oxygen supplementation during mechanical ventilation by oxidative lipidomics. The investigators will include patients with mechanical ventilation and have received FiO2=\\>0.5 atleast 90 minutes and collected two sequential mini bronchoalveolar lavage on them 24 hours apart. Mass Spectrometry Lipid chromatography will be conducted and clinical data will be analyzed.",[64,65],"Mechanical Ventilation Complication","Hyperoxia","2024-04-25",{"date":68,"type":69},"2024-04-26","ACTUAL",{"date":71,"type":69},"2023-03-01",{"date":73,"type":60},"2026-09-01",{"name":5,"class":6},1]