[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100523967":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":25,"centralContacts":25,"locations":30,"responsibleParty":94,"collaborators":25,"id":98,"slug":99,"hasResults":100,"nctId":101,"briefTitle":102,"officialTitle":103,"acronym":104,"eligibilityCriteria":105,"healthyVolunteers":100,"sex":106,"minAge":107,"maxAge":25,"enrollmentInfo":108,"targetDuration":25,"studyType":111,"phases":112,"briefSummary":114,"conditions":115,"keywords":25,"overallStatus":49,"whyStopped":25,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":118,"startDateStruct":121,"completionDateStruct":123,"leadSponsor":125,"locationsCount":126},{"fullName":5,"class":6},"Università degli Studi di Ferrara","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Individualized RBCT","EXPERIMENTAL","Requires daily assessment of hemoglobin (Hb) levels. Prescription of RCBT is restricted to patients who present Hb ≤ 9.0 g\u002FdL and O2ER ≥ 30%. If O2ER \\\u003C 30%, transfusion will take place only when Hb falls below 7.0 g\u002FdL. Further O2ER measurements during the day in this group are allowed, and the clinician should not be blinded of the results. To tolerate Hb levels below 7.0 g\u002FdL with O2ER \\\u003C 30% remains a clinical decision, documented in the CRF. Transfusion with Hb below 6.0 g\u002FdL is mandatory",[13],"Other: Individualized red blood cell transfusion strategy",{"label":15,"type":16,"description":17,"interventionNames":18},"Control group","ACTIVE_COMPARATOR","Requires daily assessment of hemoglobin levels. Prescription of RCBT is restricted to patients who present Hb ≤ 7.0 g\u002FdL, despite of O2ER values. Indeed, O2ER calculation takes place at least once daily in this group but does not interfere with clinical decision to prescribe RBCT. A liberal transfusion threshold (i.e. 9.0 g\u002FdL) is still possible in critically ill adults with acute coronary syndromes, as indicated by the European current guidelines",[19],"Other: European guidelines red blood cell transfusion strategy",[21,26],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"Individualized red blood cell transfusion strategy","Prescription of RCBT is restricted to patients who present Hb ≤ 9.0 g\u002FdL and O2ER ≥ 30%.",[9],null,{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"European guidelines red blood cell transfusion strategy","RBCT according to ESICM guidelines",[15],[31,47,67,81],{"facility":32,"status":33,"city":34,"state":25,"zip":25,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"Hospital Erasme","NOT_YET_RECRUITING","Brussels","Belgium","BE",{"type":38,"coordinates":39},"Point",[40,41],4.34878,50.85045,{"lat":41,"lon":40},[44],{"name":45,"role":46,"phone":25,"phoneExt":25,"email":25},"Fabio Silvio Taccone","CONTACT",{"facility":48,"status":49,"city":50,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":58,"contacts":59},"Università di Ferrara","RECRUITING","Ferrara","44121","Italy","IT",{"type":38,"coordinates":55},[56,57],11.62057,44.83804,{"lat":57,"lon":56},[60,64],{"name":61,"role":46,"phone":62,"phoneExt":25,"email":63},"Alberto Fogagnolo, MD","0532237231","alberto.fogagnolo@gmail.com",{"name":65,"role":46,"phone":25,"phoneExt":25,"email":66},"Savino Spadaro, PhD","savinospadaro@gmail.com",{"facility":68,"status":49,"city":69,"state":52,"zip":70,"country":52,"countryCode":53,"cosmosGeoPoint":71,"geoPoint":75,"contacts":76},"Università di Perugia","Perugia","06121",{"type":38,"coordinates":72},[73,74],12.38878,43.1122,{"lat":74,"lon":73},[77],{"name":78,"role":46,"phone":79,"phoneExt":25,"email":80},"Angelo Giacomucci","00390755783298","angelo.giacomucci@ospedale.perugia.it",{"facility":82,"status":49,"city":83,"state":25,"zip":25,"country":52,"countryCode":53,"cosmosGeoPoint":84,"geoPoint":88,"contacts":89},"Anestesia e Rianimazione Cardio-Toraco-Vascolare","Siena",{"type":38,"coordinates":85},[86,87],11.33064,43.31822,{"lat":87,"lon":86},[90],{"name":91,"role":46,"phone":92,"phoneExt":25,"email":93},"Federico Franchi","0577 586819.","federico.franchi@unisi.it",{"type":95,"investigatorFullName":96,"investigatorTitle":97,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Alberto Fogagnolo","Dr","100523967","oxygen-extraction-guided-transfusion-100523967",false,"NCT06102590","Oxygen Extraction-guided Transfusion","Oxygen Extraction-guided Transfusion Strategy in Critically Ill Patients. A Randomized Controlled Trial.","OXYTRIP","Inclusion Criteria:\n\n* Hb levels ≤ 9.0 g\u002FdL (as confirmed through a blood test and\u002For through blood gas analysis)\n* Presence of an arterial line and a central venous line (either jugular or subclavian), with confirmed correct position of the catheter tip at the atrio-caval junction (allowing correct estimation of central venous saturation, ScvO2).\n\nExclusion Criteria:\n\n* Age \\\u003C 18 years;\n* Pregnancy\n* Clinical evidence of acute bleeding\n* Diagnosis of haematological malignancy\n* Diagnosis of sickle cell disease, or other diseases exposing the patient to chronic RCBTs\n* Acquired or congenital disorders of coagulation\n* Patients with ongoing AKI of stage 1 or worse and\u002For known chronic kidney disease (CKD) of stage G3a or worse, defined as glomerular filtration rate below 60 for a minimum of 3 months","ALL","18 Years",{"count":109,"type":110},324,"ESTIMATED","INTERVENTIONAL",[113],"NA","In critically ill patients, optimized strategies for red blood cells transfusion (RBCT) are still controversial. Most recent guidelines suggest that clinical practice in ICU setting should follow a restrictive approach to RBCT (i.e., hemoglonim level \\\u003C 7.0 g\u002FdL).In our previous study, oxygen extraction ratio (O2ER) has shown good performance as a marker to identify the correct timing for RBCT, potentially affecting 90-day mortality in non-bleeding, critically ill patients \\[11\\]. Moreover, our data suggested that an individualized strategy for RBCT may reduce the incidence of acute kidney injury (AKI), which is possibly related to a better delivery of oxygen and organ perfusion.",[116],"Blood Transfusion","2026-04-27",{"date":119,"type":120},"2026-05-01","ACTUAL",{"date":122,"type":120},"2023-11-04",{"date":124,"type":110},"2027-01-01",{"name":5,"class":6},4]