[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100624863":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":32,"locations":41,"responsibleParty":56,"collaborators":18,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":18,"eligibilityCriteria":65,"healthyVolunteers":66,"sex":67,"minAge":68,"maxAge":18,"enrollmentInfo":69,"targetDuration":18,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":79,"overallStatus":83,"whyStopped":18,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"Istanbul University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Oxygen Reserve Index","EXPERIMENTAL","Participants in this arm will undergo continuous Oxygen Reserve Index (ORi) monitoring in addition to standard anesthesia monitoring during general anesthesia with apneic intermittent ventilation for endolaryngeal surgery. ORi values will be used to guide the timing of reventilation, with reventilation initiated when ORi reaches zero, indicating depletion of oxygen reserve. Standard clinical care and anesthesia management will otherwise be identical to the control group.",[13],"Procedure: oxygen monitoring techniques",{"label":15,"type":16,"description":17,"interventionNames":18},"Peripheral oxygen saturation","NO_INTERVENTION","Participants in this arm will receive standard anesthesia monitoring, including continuous peripheral oxygen saturation (SpO₂) monitoring, during general anesthesia with apneic intermittent ventilation for endolaryngeal surgery. The timing of reventilation will be guided by SpO₂ values, with reventilation initiated when SpO₂ decreases to 90%. All other aspects of anesthesia care and perioperative management will be identical to the experimental arm.",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":18},"PROCEDURE","oxygen monitoring techniques","to determine whether ORi monitoring provides earlier and clinically meaningful warning of oxygen reserve depletion compared with conventional pulse oximetry, potentially improving patient safety during shared-airway surgery.",[9],[26,29],{"name":27,"affiliation":5,"role":28},"ece naz demir, resident","PRINCIPAL_INVESTIGATOR",{"name":30,"affiliation":5,"role":31},"demet altun, prof","STUDY_DIRECTOR",[33,38],{"name":34,"role":35,"phone":36,"phoneExt":18,"email":37},"Demet Altun, Prof","CONTACT","00905326811767","drdemetaltun@hotmail.com",{"name":27,"role":35,"phone":39,"phoneExt":18,"email":40},"00905064524892","ecenazdemir95@gmail.com",[42],{"facility":43,"status":18,"city":44,"state":45,"zip":46,"country":47,"countryCode":18,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"Istanbul University, Department of anesthesiology","Istanbul","Fatih","34093","Turkey (Türkiye)",{"type":49,"coordinates":50},"Point",[51,52],28.94966,41.01384,{"lat":52,"lon":51},[55],{"name":30,"role":35,"phone":36,"phoneExt":18,"email":37},{"type":28,"investigatorFullName":57,"investigatorTitle":58,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"Demet Altun","Professor","100624863","oxygen-reserve-index-ori-in-identifying-desaturation-100624863",false,"NCT07415161","Oxygen Reserve Index (ORi) in Identifying Desaturation","The Role of Oxygen Reserve Index (ORi) in Identifying Early Desaturation During Endolaryngeal Surgery: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Age 18 years or older\n* Scheduled for elective endolaryngeal surgery\n* Planned general anesthesia with apneic intermittent ventilation\n* American Society of Anesthesiologists (ASA) physical status I-III\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Age under 18 years\n* Preoperative chronic hypoxemia (baseline SpO₂ \\\u003C 95%)\n* Patients transferred from the intensive care unit\n* ASA physical status IV or higher\n* Refusal or inability to provide informed consent",true,"ALL","18 Years",{"count":70,"type":71},80,"ESTIMATED","INTERVENTIONAL",[74],"NA","This randomized clinical trial investigates whether Oxygen Reserve Index (ORi) monitoring enables earlier detection of impending hypoxemia compared with conventional pulse oximetry during apneic intermittent ventilation in adult patients undergoing endolaryngeal surgery under general anesthesia. By providing continuous, noninvasive assessment of oxygen reserve in the hyperoxic range, ORi may offer an earlier warning of oxygen depletion before peripheral oxygen saturation declines. The study compares time to reventilation thresholds, arterial blood gas parameters, and perioperative respiratory outcomes between ORi-guided and standard SpO₂-guided monitoring strategies.",[77,78,9],"Apneic Oxygenation","Endolarengeal Surgery",[80,81,82],"oxygen reserve index","pulse oximetry","apneic ventilation","NOT_YET_RECRUITING","2026-02-15",{"date":86,"type":87},"2026-02-17","ACTUAL",{"date":89,"type":71},"2026-01-27",{"date":91,"type":71},"2026-03-25",{"name":5,"class":6},1]