[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100365642":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":29,"centralContacts":36,"locations":44,"responsibleParty":61,"collaborators":18,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":18,"eligibilityCriteria":69,"healthyVolunteers":65,"sex":70,"minAge":71,"maxAge":72,"enrollmentInfo":73,"targetDuration":18,"studyType":76,"phases":77,"briefSummary":79,"conditions":80,"keywords":82,"overallStatus":47,"whyStopped":18,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"IRCCS Burlo Garofolo","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Ozone therapy","EXPERIMENTAL","Ozone application before pits and fissure sealants",[13,14],"Device: Ozone","Other: Pits and fissure sealants",{"label":16,"type":17,"description":18,"interventionNames":19},"Pits and fissure sealants","ACTIVE_COMPARATOR",null,[14],[21,26],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":18},"DEVICE","Ozone","One minute of pretreatment with ozone by using the OzoneDTA device",[9],{"type":6,"name":16,"description":27,"armGroupLabels":28,"otherNames":18},"cleansing of the occlusal surfaces with a nylon brush and polishing toothpaste; surface etching with 36% orthophosphoric acid for 30'', surface cleaning and drying for 30 '', application of the sealing material, polymerization for 60'';",[9,16],[30,33],{"name":31,"affiliation":5,"role":32},"Milena Cadenaro, DDS,MSc,PhD","STUDY_CHAIR",{"name":34,"affiliation":5,"role":35},"Maddalena Chermetz, DDS,MSc","PRINCIPAL_INVESTIGATOR",[37,41],{"name":31,"role":38,"phone":39,"phoneExt":18,"email":40},"CONTACT","+390403785358","milena.cadenaro@burlo.trieste.it",{"name":42,"role":38,"phone":39,"phoneExt":18,"email":43},"Chiara Navarra, DDS,MSc,PhD","chiara.navarra@burlo.trieste.it",[45],{"facility":46,"status":47,"city":48,"state":48,"zip":49,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"Institute for Maternal and Child Health - IRCCS Burlo Garofolo-","RECRUITING","Trieste","34137","Italy","IT",{"type":53,"coordinates":54},"Point",[55,56],13.77678,45.64953,{"lat":56,"lon":55},[59],{"name":60,"role":38,"phone":18,"phoneExt":18,"email":40},"Milena Cadenaro",{"type":62,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR","100365642","ozone-application-before-fissure-sealants-100365642",false,"NCT04040920","Ozone Application Before Fissure Sealants","The Effect of Ozone Application Before Fissure Sealants: a Split Mouth Randomized Controlled Trial","Inclusion Criteria:\n\n* first or second secondary molars to be sealed\n* possibility to isolate with rubber dam both the teeth involved\n* no clear signs of pigmentations\n* good general health\n\nExclusion Criteria:\n\n* latex allergy\n* epilepsy or other severe neurological pathologies\n* psychiatric disease\n* excessive sensibility to electrical current\n* severe asthma\n* enamel disorders, such as amelogenesis imperfect, white spots, fluorosis or Molar Incisors Hypomineralization","ALL","6 Years","16 Years",{"count":74,"type":75},67,"ESTIMATED","INTERVENTIONAL",[78],"NA","Decay is a multifactorial infective degenerative disease of hard dental tissues, caused by Streptococcus mutans and Lactobacillus forming the bacterial biofilm of teeth surfaces. Decays generally evolve in fissures and pits of secondary molars. Pits and fissure sealants prevent decays if performed in two years from eruption. Ozone has bactericidal effect and remineralizing capacity on enamel.\n\nThe aim of this study is to assess the effectiveness of ozone application before sealants in increasing their duration in time.",[81],"Caries,Dental",[23,83,84],"Pits and fissures sealants","Prevention","2025-05-13",{"date":87,"type":88},"2025-05-16","ACTUAL",{"date":90,"type":88},"2019-06-17",{"date":92,"type":75},"2026-12-31",{"name":5,"class":6},1]