[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100591457":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":35,"locations":45,"responsibleParty":64,"collaborators":26,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":26,"eligibilityCriteria":73,"healthyVolunteers":74,"sex":75,"minAge":76,"maxAge":26,"enrollmentInfo":77,"targetDuration":26,"studyType":80,"phases":81,"briefSummary":83,"conditions":84,"keywords":86,"overallStatus":48,"whyStopped":26,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"University of Bari","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Ozonized Olive Oil Intervention Group","EXPERIMENTAL","It has been administrated in the form of gel once a week for three weeks",[13],"Device: Activated Ozonized Olive Oil Gel",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo Controlled Group","PLACEBO_COMPARATOR","Same description of Interventional Group",[19],"Other: Placebo gel",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Activated Ozonized Olive Oil Gel","It is a natural oil which has been ozonized to improve the antimicrobial activity against periodontopathogenic bacterias",[9],null,{"type":6,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Placebo gel","Placebo gel with same texture, color, way of administration and taste of Activated Ozonized Olive Oil Gel",[15],[32],{"name":33,"affiliation":5,"role":34},"Massimo Petruzzi, PhD, MD","PRINCIPAL_INVESTIGATOR",[36,42],{"name":37,"role":38,"phone":39,"phoneExt":40,"email":41},"Fabio Vittorio Ciccone, MD","CONTACT","3887589165","+39","fabio.ciccone5@gmail.com",{"name":33,"role":38,"phone":43,"phoneExt":40,"email":44},"3335763120","massimo.petruzzi@uniba.it",[46],{"facility":47,"status":48,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"Odontostomatologic Departement of Policlinic of Bari","RECRUITING","Bari","BA","70124","Italy","IT",{"type":55,"coordinates":56},"Point",[57,58],16.86982,41.12066,{"lat":58,"lon":57},[61,62],{"name":33,"role":38,"phone":43,"phoneExt":40,"email":44},{"name":37,"role":63,"phone":26,"phoneExt":26,"email":26},"SUB_INVESTIGATOR",{"type":34,"investigatorFullName":65,"investigatorTitle":66,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Massimo Petruzzi","Clinical Professor of Odontostomatology","100591457","ozonized-olive-oil-in-the-treatment-of-periodontal-pockets-100591457",false,"NCT06980675","Ozonized Olive Oil in the Treatment of Periodontal Pockets","Clinical and Microbiological Study on Local Application of an Ozonated Olive Oil Gel in the Periodontal Pockets: a Randomized Double-blind Trial.","Inclusion Criteria:\n\n* Patients with stage II, III, or IV periodontitis according to the new 2017 World Workshop periodontal classification\n* Patients of either sex and older than 18 years of age\n* Probing Pocket Depth (PPD) greater than or equal to 4 mm at 3 sites\n* Patients who have signed consent to the study\n* Collaborating patients\n\nExclusion Criteria:\n\n* age \\\u003C 18 years and\u002For inability to provide written informed consent;\n* absence of family or social welfare support;\n* non-drug-induced gingival hypertrophy,\n* severe smokers (more than 20 cigarettes per day),\n* consumers of high levels of alcohol,\n* patients on corticosteroid treatment,\n* diabetic patient,\n* immunodepressive therapies,\n* chemotherapies,\n* radiotherapies,\n* pregnancy states;\n* lack of collaboration for ongoing postoperative reevaluations.",true,"ALL","18 Years",{"count":78,"type":79},20,"ESTIMATED","INTERVENTIONAL",[82],"NA","A randomized controlled clinical trial was conducted on 16 patients (8 males and 8 women) who were diagnosed chronic periodontitis. All the patients has been divided by randomization in two groups: control group treated with placebo gel and experimental group treated with gel based on ozonated EVO olive oil.\n\nBoth group after the evaluation of inclusion and exclusion criteria during the first visit, were subjected to hygiene treatment of removal tartar deposit, considered as standard of therapy for periodontitis.\n\nAfter 15 days the hygiene treatment, patients were been randomized in two groups following the flow chart (t0) starting with: periodontal probing, microbiological samples and the first administration of gel. Next week (t1), has been collected the compliance and did the second administration of gel; the procedures will be the same also for another week (t2), until the last week (t3) when has been registered the second periodontal probing and did the second microbiological samples.\n\nData were collected to software Microsoft Excel and all the data analysis were conducted on this software to highlight significant differences between both groups. As the primary outcome was continuous variable and assuming normal distribution bilateral parametric test T-student was performed. An alpha error of 5% was considered, Beta error was not calculated as this was a pilot study.",[85],"Periodontal Pocket",[87,85,88],"Ozonated Olive Oil","Periodontal Disease","2025-05-16",{"date":91,"type":92},"2025-05-20","ACTUAL",{"date":94,"type":92},"2021-10-25",{"date":96,"type":79},"2025-05",{"name":5,"class":6},1]