[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100481957":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":36,"locations":47,"responsibleParty":64,"collaborators":68,"id":73,"slug":74,"hasResults":75,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":79,"eligibilityCriteria":80,"healthyVolunteers":75,"sex":81,"minAge":82,"maxAge":83,"enrollmentInfo":84,"targetDuration":30,"studyType":87,"phases":88,"briefSummary":90,"conditions":91,"keywords":30,"overallStatus":50,"whyStopped":30,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":104},{"fullName":5,"class":6},"Simon Fraser University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Counterpressure Maneuvers","EXPERIMENTAL","Participants will receive standard of care treatment (behavioural intervention and avoidance measures, as indicated in \"Usual Care\"), alongside training in counter pressure maneuvers. Training in counterpressure maneuvers will be delivered through a handout and video that will show three maneuvers (i.e. arm-tensing, squatting, and leg-crossing) that patients enrolled in the intervention arm can perform when they begin to experience common signs and symptoms of syncope. Patients will be instructed to start with one of the maneuvers and if their symptoms do not go away, move on to a second or third maneuver if needed.",[13],"Behavioral: Counterpressure Maneuvers",{"label":15,"type":16,"description":17,"interventionNames":18},"Usual Care","ACTIVE_COMPARATOR","Participants will receive standard of care treatment for their diagnosis of syncope. This primarily includes behavioural interventions and avoidance measures (e.g., stay hydrated, increase salt intake, avoid hot situations, avoid standing for long periods of time, engage in regular physical activity). Some patients may be prescribed medication (Midodrine, Fludrocortisone) at the discretion of their physician.",[19],"Behavioral: Usual Care",[21,27],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"BEHAVIORAL","Movements that can aid in delaying or preventing syncope by recruiting skeletal muscle pumping (via compression of major veins by contracting muscle to eject blood through cardiovascular circuit) and increased sympathetic drive (via sustaining an isometric muscle contraction). In this trial, we will be evaluating three commonly recommended maneuvers of arm tensing, squatting, and leg crossing with arm tensing. Maneuvers should be held for 1-2 minutes, or until symptoms subside.",[9],[26],"Physical counter maneuvers, counter maneuvers,",{"type":22,"name":15,"description":28,"armGroupLabels":29,"otherNames":30},"Participants will engage in behavioural interventions and avoidance measures that are commonly recommended as a part of usual care for recurrent syncope. This primarily includes recommendations such as staying hydrated, increasing salt intake, avoiding warm temperatures, avoiding standing for long periods of time, and engaging in regular physical activity. Some patients may be prescribed medication (Midodrine, Fludrocortisone), or other assistive interventions (e.g., compression stockings) at the discretion of their physician.",[15],null,[32],{"name":33,"affiliation":34,"role":35},"Shubhayan Sanatani, MD","University of British Columbia","PRINCIPAL_INVESTIGATOR",[37,42],{"name":38,"role":39,"phone":40,"phoneExt":30,"email":41},"Erin L Williams, BSc","CONTACT","6048976372","erin_williams_2@sfu.ca",{"name":43,"role":39,"phone":44,"phoneExt":45,"email":46},"Sonia Franciosi, PhD","(604) 875-2345","7955","Sonia.Franciosi@cw.bc.ca",[48],{"facility":49,"status":50,"city":51,"state":52,"zip":53,"country":54,"countryCode":55,"cosmosGeoPoint":56,"geoPoint":61,"contacts":62},"BC Children's Hospital","RECRUITING","Vancouver","British Columbia","V6H3N1","Canada","CA",{"type":57,"coordinates":58},"Point",[59,60],-123.11934,49.24966,{"lat":60,"lon":59},[63],{"name":43,"role":39,"phone":44,"phoneExt":45,"email":46},{"type":65,"investigatorFullName":66,"investigatorTitle":67,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"SPONSOR_INVESTIGATOR","Dr. Victoria Claydon","Professor",[69,71,72],{"name":70,"class":6},"Provincial Health Services Authority British Columbia",{"name":34,"class":6},{"name":5,"class":6},"100481957","paediatric-syncope-in-the-emergency-department-100481957",false,"NCT05555771","Paediatric Syncope in the Emergency Department","Determining the Effectiveness of Counterpressure Maneuvers in Pediatric Patients Presenting With Syncope to the Emergency Department","DETECT-ED","Inclusion Criteria:\n\n1. Those between the ages of 6-18 years (inclusive)\n2. Presenting to the ED daily 1000-2200 with resolved transient loss of consciousness that has occurred within the last week\n3. Able to complete the survey in English\n4. Willing and able to provide consent and assent\n\nExclusion Criteria:\n\n1. Those with a known history of any of the following:\n\n   * Suspected or confirmed cardiac arrhythmia diagnosis (e.g., Wolff-Parkinson-White, long QT)\n   * Traumatic head injury\n   * New presentation of seizure disorder\n   * Epilepsy recurrence\n   * Overdose, intoxication\n   * Structural heart disease\n2. Patients with hypoglycaemia and who are psychogenic with vasovagal syncope who do not present with prodromal symptoms\n3. Previously enrolled in this study","ALL","6 Years","18 Years",{"count":85,"type":86},300,"ESTIMATED","INTERVENTIONAL",[89],"NA","The investigators will assess the efficacy of clinically recommended counterpressure maneuvers (CPM) in preventing syncope for paediatric patients. Participants presenting to the emergency department (ED) will first provide written informed consent. In stage I, they will be asked to complete a brief survey documenting the presentation of their syncopal episode, and any prodromal symptoms they experienced. Participants that consent to the second stage of the study will either receive usual care (control arm) or training in counter pressure maneuvers alongside usual care (intervention arm; leg crossing, bending, arm tensing). These patients will be followed for one years time, and will be asked to complete monthly surveys detailing their syncopal and presyncopal recurrence. Medical records will be accessed over the duration of the study to identify any changes in medical diagnosis.",[92,93,94],"Syncope, Vasovagal","Postural Orthostatic Tachycardia Syndrome","Orthostatic Intolerance","2026-04-22",{"date":97,"type":98},"2026-04-23","ACTUAL",{"date":100,"type":98},"2022-09-03",{"date":102,"type":86},"2027-09-30",{"name":66,"class":6},1]