[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100615273":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":30,"centralContacts":35,"locations":47,"responsibleParty":63,"collaborators":25,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":25,"eligibilityCriteria":73,"healthyVolunteers":74,"sex":75,"minAge":76,"maxAge":77,"enrollmentInfo":78,"targetDuration":25,"studyType":81,"phases":82,"briefSummary":84,"conditions":85,"keywords":92,"overallStatus":103,"whyStopped":25,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":113},{"fullName":5,"class":6},"Medipol University","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Morning Chronotype","EXPERIMENTAL","Participants classified as morning chronotype using the Munich Chronotype Questionnaire (MCTQ) will attend both a morning session and an evening session in randomized order with at least 72 hours between visits. Within each session the participant completes both a 12-minute supervised deep-breathing control condition and a 12-minute High-Intensity Functional Training (HIFT) intervention, separated by a 30-minute break to minimize carryover effects. Pain perception is assessed before and after each condition.",[13,14],"Behavioral: High-Intensity Functional Training (HIFT)","Behavioral: Supervised Deep Breathing",{"label":16,"type":10,"description":17,"interventionNames":18},"Evening Chronotype","Participants classified as evening chronotype using the Munich Chronotype Questionnaire (MCTQ) will attend both a morning session and an evening session in randomized order with at least 72 hours between visits. Within each session the participant completes both a 12-minute supervised deep-breathing control condition and a 12-minute High-Intensity Functional Training (HIFT) intervention, separated by a 30-minute break to minimize carryover effects. Pain perception is assessed before and after each condition.",[13,14],[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"BEHAVIORAL","High-Intensity Functional Training (HIFT)","A 12-minute, instructor-led HIFT protocol delivered via the same video to all participants. After a 5-minute warm-up, participants perform six exercises targeting major muscle groups. The exercises are 4 lunges followed by one push-up, 10 high knees followed by 10 shuffles, burpees, squat jumps, skaters, and plank up-downs. Each exercise is done for 40 seconds then 20 seconds rest. The cycle repeats twice for a total of 12 minutes. Rate of Perceived Exertion (Borg scale) is recorded at baseline, post-warmup, during each rest interval, and immediately post-exercise. A physiotherapist supervises performance, ensures correct technique, and enforces safety and target intensity while motivating and encouraging the participant.",[16,9],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Supervised Deep Breathing","A 12-minute deep breathing session delivered via a prerecorded audio and supervised by a physiotherapist. The breathing rhythm includes inhaling for 4 seconds and exhaling for 6 seconds for a total 1 minute, followed by 1 minute of normal breathing. This cycle is repeated six times for a total duration of 12 minutes. Participants lie supine in a comfortable position and wear headphones. A self-reported Rate of Perceived Relaxation (RPR, 0-10) is recorded before and after. This serves as a non-exercise control to account for relaxation and attention effects.",[16,9],[31],{"name":32,"affiliation":33,"role":34},"Gizem Ergezen Şahin, Dr. Assistant Professor","Department of Physiotherapy and Rehabilitation\u002FIstanbul Medipol University","STUDY_DIRECTOR",[36,42],{"name":37,"role":38,"phone":39,"phoneExt":40,"email":41},"Fatema Mohamed Soliman, PT, MSc (Cand.)","CONTACT","+90 537 736 20 79","+20 15 0156870","pt.fatemasoliman@gmail.com",{"name":43,"role":38,"phone":44,"phoneExt":45,"email":46},"Aliaa Salem Menshawi, PT, MSc (Cand.)","+905527304660","+96550268508","aliaamenshawi@gmail.com",[48],{"facility":49,"status":25,"city":50,"state":51,"zip":52,"country":53,"countryCode":25,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"Istanbul Medipol University","Istanbul","Beykoz","34810","Turkey (Türkiye)",{"type":55,"coordinates":56},"Point",[57,58],28.94966,41.01384,{"lat":58,"lon":57},[61],{"name":37,"role":38,"phone":39,"phoneExt":40,"email":62},"fatema.mohammed200088@gmail.com",{"type":64,"investigatorFullName":65,"investigatorTitle":66,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Fatema Mohamed Daoud Soliman","Principal Investigator","100615273","pain-perception-and-exercise-induced-hypoalgesia-across-circadian-rhythms-100615273",false,"NCT07290465","Pain Perception and Exercise-Induced Hypoalgesia Across Circadian Rhythms","Exploring Pain Perception Through Exercise-Induced Hypoalgesia Across Circadian Rhythms for Healthy Participants","Inclusion Criteria:\n\n* Healthy participants\n* age 18 to 40 years\n* good level of English that allow the enrolled participant to provide informed consent and complete the questionnaires provided\n* being categorized as \"moderate\" in the International Physical Activity Questionnaire (IPAQ)\n\nExclusion Criteria:\n\n* inability to report pain intensity reliably\n* consumption of narcotics or tobacco products\n* regularly taking pain medications and analgesics\n* pregnant or planning to get pregnant\n* surgery within the last 12 months\n* acute or chronic pain conditions\n* uncontrolled hypertension\n* cardiovascular diseases, pulmonary diseases, neurological diseases with significant changes in somatosensory and pain perception, metabolic diseases, serious systemic diseases or conditions that restrict normal daily activities, inflammatory conditions (e.g. rheumatoid arthritis), or orthopedic injuries\n* intolerable pain during the pain perception test\n* serious psychiatric conditions (e.g., schizophrenia and bipolar disorder) or psychological disorders (e.g., depression) that may affect pain thresholds (16).\n* Severe sleep disorders and circadian rhythm disturbances\n* BMI \\> 30\n* serious fatigue or delayed-onset muscle soreness (9) at least 24 h after exercise sessions or a sudden change in activity for more than one week",true,"ALL","18 Years","40 Years",{"count":79,"type":80},56,"ESTIMATED","INTERVENTIONAL",[83],"NA","The goal of this randomized crossover clinical trial is to investigate whether exercise-induced hypoalgesia (EIH) is influenced by circadian rhythm in healthy adults aged 18-40 years.\n\nThe main questions it aims to answer are:\n\n* Does the time of day (morning vs. evening) influence changes in pain perception following exercise?\n* Do chronotype, sex, or stimulation site (bony vs. muscular) alter the magnitude of this effect?\n\nParticipants will:\n\n* Complete questionnaires\n* Undergo quantitative sensory testing\n* Attend both morning and evening sessions in randomized crossover order",[86,87,88,89,90,91],"Exercise Induced Hypoalgesia","Circadian Rhythm","Pain Perception","Healthy Participants","Chronotype","Physical Therapy",[93,88,87,90,89,94,27,95,96,97,98,99,91,100,101,102],"Exercise-Induced Hypoalgesia","High-Intensity Functional Training","Pressure Pain Threshold (PPT)","Pain pressure tolerance threshold (PPTol)","Quantative Sensory Testing","Bony Landmarks","Muscular Landmarks","Randomized Control Trial","Crossover","Pain Management","NOT_YET_RECRUITING","2025-12-04",{"date":106,"type":107},"2025-12-18","ACTUAL",{"date":109,"type":80},"2026-01",{"date":111,"type":80},"2026-04",{"name":5,"class":6},1]