[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100567415":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":39,"centralContacts":44,"locations":53,"responsibleParty":69,"collaborators":27,"id":73,"slug":74,"hasResults":75,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":27,"eligibilityCriteria":79,"healthyVolunteers":80,"sex":81,"minAge":82,"maxAge":83,"enrollmentInfo":84,"targetDuration":27,"studyType":87,"phases":88,"briefSummary":90,"conditions":91,"keywords":27,"overallStatus":97,"whyStopped":27,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":107},{"fullName":5,"class":6},"Balgrist University Hospital","OTHER",[8,16],{"label":9,"type":10,"description":11,"interventionNames":12},"taVNS","EXPERIMENTAL","Electrodes will be attached to the outer ear. Electrical stimulation pulses with a width of 250ms will be applied at a frequency of 25Hz. Stimulation intensity will be individually adjusted to be clearly perceived but not painful.",[13,14,15],"Other: respiratory gated taVNS","Other: random burst stimulation","Other: continuous stimulation",{"label":17,"type":18,"description":19,"interventionNames":20},"Sham stimulation","SHAM_COMPARATOR","Electrodes will be attached to the outer ear at a different position as for the taVNS. Electrical stimulation pulses with a width of 250ms will be applied at a frequency of 25Hz. Stimulation intensity will be individually adjusted to be clearly perceived but not painful.",[21],"Other: Sham stimulation",[23,28,32,36],{"type":6,"name":24,"description":25,"armGroupLabels":26,"otherNames":27},"respiratory gated taVNS","Electrical stimulation will be delivered in bursts during expiration",[9],null,{"type":6,"name":29,"description":30,"armGroupLabels":31,"otherNames":27},"random burst stimulation","Electrical stimulation will be delivered in bursts at random timepoints during the breathing cycle",[9],{"type":6,"name":33,"description":34,"armGroupLabels":35,"otherNames":27},"continuous stimulation","Electrical stimulation will be delivered continuously for 30sec followed by a 30sec break.",[9],{"type":6,"name":17,"description":37,"armGroupLabels":38,"otherNames":27},"Electrical stimulation will be identical to the taVNS, but the electrodes will be placed at a different position on the ear",[17],[40],{"name":41,"affiliation":42,"role":43},"Petra Schweinhardt, PhD, M Chiro Med","Balgrist University Hospital, University of Zurich, Zurich, Switzerland","PRINCIPAL_INVESTIGATOR",[45,49],{"name":41,"role":46,"phone":47,"phoneExt":27,"email":48},"CONTACT","+41 443865724","petra.schweinhardt@balgrist.ch",{"name":50,"role":46,"phone":51,"phoneExt":27,"email":52},"Madeleine Hau","+41 443865711","madeleine.hau@balgrist.ch",[54],{"facility":5,"status":27,"city":55,"state":56,"zip":57,"country":58,"countryCode":59,"cosmosGeoPoint":60,"geoPoint":65,"contacts":66},"Zurich","Canton of Zurich","8008","Switzerland","CH",{"type":61,"coordinates":62},"Point",[63,64],8.55,47.36667,{"lat":64,"lon":63},[67],{"name":50,"role":46,"phone":68,"phoneExt":27,"email":52},"+41 44 386 57 11",{"type":70,"investigatorFullName":71,"investigatorTitle":72,"investigatorAffiliation":5,"oldNameTitle":27,"oldOrganization":27},"SPONSOR_INVESTIGATOR","Schweinhardt Petra","Prof. Dr. med.","100567415","pain-perception-and-the-autonomic-nervous-system-100567415",false,"NCT06667895","Pain Perception and the Autonomic Nervous System","Influences of the Autonomic Nervous System on Experimental Pain Sensitization","Inclusion Criteria:\n\n1. Over 18 and below 40 years of age\n2. Good general health\n3. Able to give informed consent\n\nExclusion Criteria:\n\n1. Any major medical or psychiatric condition (e.g. heart disease, diabetes, autoimmune disorders, infectious diseases, major depressive disorder), any chronic pain condition, any respiratory problems, any acute pain at time of study\n2. Inability to follow study instructions, e.g. due to language problems\n3. Pregnancy (female participants will be asked if pregnancy could be possible)\n4. Increased alcohol (\\>2 (for women)\u002F4 (for men) standard glasses per day or \\>5 (for women)\u002F4 (for men) glasses at least once a month within a few hours) or caffeine consumption (≥ 400mg per day)\n5. Consumption of alcohol, drugs, analgesics within the last 24 h\n6. Consumption of more than 100 mg of caffeine within the last 8 h\n7. Scar tissue or generally reduced sensitivity in the designated testing site areas\n8. Shoe size \\< 38 (if experiment is conducted at the feet)\n9. History of cardiovascular disease or carotid artery disease\n10. Medication or Substances inferring with the autonomic nervous system or with pain sensitivity (e.g. Benzodiazepines, Nicotine)",true,"ALL","18 Years","40 Years",{"count":85,"type":86},146,"ESTIMATED","INTERVENTIONAL",[89],"NA","In this study, we want to investigate how pain processing and sensation are related to a certain part of the nervous system, the so-called autonomic nervous system.\n\nFor this purpose, we apply heat and pressure stimuli to the skin and test pain processing by means of ratings scales and sensory tests. Breathing, heart rate and sweat response are also measured. To assess the spinal cord level, we measure muscle response (measured by electromyography, EMG) to electrical stimulation. Additionally, sensory nerves will be stimulated at the ear and participants will also be given various questionnaires to complete.",[92,93,94,95,96],"Autonomic Nervous System Modulation","Pain Perception","Pain Sensitivity","Central Sensitization","Vagus Nerve Stimulations","NOT_YET_RECRUITING","2024-10-30",{"date":100,"type":101},"2024-10-31","ACTUAL",{"date":103,"type":86},"2024-11-04",{"date":105,"type":86},"2026-08",{"name":71,"class":6},1]