[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100613000":3},{"organization":4,"armGroups":7,"interventions":15,"overallOfficials":38,"centralContacts":43,"locations":49,"responsibleParty":67,"collaborators":10,"id":70,"slug":71,"hasResults":72,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":10,"eligibilityCriteria":76,"healthyVolunteers":77,"sex":78,"minAge":79,"maxAge":10,"enrollmentInfo":80,"targetDuration":10,"studyType":83,"phases":10,"briefSummary":84,"conditions":85,"keywords":91,"overallStatus":51,"whyStopped":10,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":107},{"fullName":5,"class":6},"Wonkwang University Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Laparoscopic Surgery Cohort",null,"Adults undergoing elective laparoscopic major abdominal surgery under general anesthesia at a single academic hospital. Each participant may receive up to two standardized 250-mL crystalloid fluid challenges (pre- and post-pneumoperitoneum). SVV and PVI are recorded around each bolus; no assignment or experimental treatment.",[13,14],"Device: Stroke Volume Variation (SVV) monitoring","Device: Pleth Variability Index (PVI) monitoring",[16,28],{"type":17,"name":18,"description":19,"armGroupLabels":20,"otherNames":21},"DEVICE","Stroke Volume Variation (SVV) monitoring","Non-investigational physiologic monitoring. SVV derived from the invasive arterial pressure waveform using a commercially available platform. Used as an index test; values recorded immediately before and \\~3 minutes after a standardized 250-mL crystalloid bolus at up to two time points (pre- and post-pneumoperitoneum). Readings are masked to clinicians; operation per usual care.",[9],[22,23,24,25,26,27],"SVV","Arterial pressure waveform analysis","FloTrac","EV1000","HemoSphere","Edwards Lifesciences",{"type":17,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"Pleth Variability Index (PVI) monitoring","Non-investigational pulse-oximetry-derived index. PVI obtained from a commercial monitor. Used as a paired index test; values recorded immediately before and \\~3 minutes after each 250-mL crystalloid bolus (up to two time points). Readings masked; monitor used within standard care.",[9],[33,34,35,36,37],"PVI","Pleth variability Index","Pulse oximetry-derived variability","Masimo","Radical-7",[39],{"name":40,"affiliation":41,"role":42},"Cheolhyeong Lee, MD, PhD","Wonkwang University School of Medicine Hospital","PRINCIPAL_INVESTIGATOR",[44],{"name":45,"role":46,"phone":47,"phoneExt":10,"email":48},"Cheol Lee, MD,PhD","CONTACT","+82-859-1564","ironyii70@gmail.com",[50],{"facility":41,"status":51,"city":52,"state":53,"zip":54,"country":55,"countryCode":10,"cosmosGeoPoint":56,"geoPoint":61,"contacts":62},"RECRUITING","Iksan","Jeollabuk-do","54538","South Korea",{"type":57,"coordinates":58},"Point",[59,60],126.95444,35.94389,{"lat":60,"lon":59},[63],{"name":64,"role":46,"phone":65,"phoneExt":10,"email":66},"Cheol Lee, M.D.,Ph.D.","01066131252","ironyii@wku.ac.kr",{"type":42,"investigatorFullName":68,"investigatorTitle":69,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Cheol Lee,MD,PhD,","Professor","100613000","paired-comparison-of-svv-and-pvi-accuracy-100613000",false,"NCT07260890","Paired Comparison of SVV and PVI Accuracy","Diagnostic Accuracy of Stroke Volume Variation (SVV) vs Pleth Variability Index (PVI) for Predicting Fluid Responsiveness in Laparoscopic Major Abdominal Surgery-A Prospective, Paired, Cohort Study","Inclusion Criteria:\n\n* Age ≥18 years\n* ASA physical status I-III\n* Elective laparoscopic major abdominal surgery under general anesthesia\n* Arterial line in place for clinical care\n* Able to provide informed consent\n* Arterial and plethysmographic waveforms adequate for measurement\n\nExclusion Criteria:\n\n* linically significant arrhythmia (e.g., atrial fibrillation with irregular R-R)\n* Severe valvular heart disease or intracardiac shunt\n* Pregnancy\n* Severe right-heart failure or condition where a fluid bolus is unsafe\n* Ongoing hemodynamic instability requiring rapid vasoactive titration at assessment\n* Persistently unreliable arterial\u002Fpleth signals despite optimization\n* Any situation the anesthesiologist judges that the fluid challenge is unsafe",true,"ALL","19 Years",{"count":81,"type":82},300,"ESTIMATED","OBSERVATIONAL","This study will compare two operating-room monitors-stroke volume variation (SVV, from the arterial line) and the Pleth Variability Index (PVI, from the pulse oximeter)-to see which one more accurately predicts whether giving a small fluid bolus will improve the heart's pumping during laparoscopic major abdominal surgery. Adults having elective surgery under general anesthesia will receive two small, timed 250-mL crystalloid infusions as part of routine care (one before and one after creation of the pneumoperitoneum). The research team will record SVV and PVI values just before and three minutes after each infusion while keeping these readings hidden from the clinicians so that usual care is not changed. No experimental drugs or devices are used. The main goal is to learn which index better identifies \"fluid responsiveness,\" so future care can be safer and more consistent. Potential risks are minimal and relate to the small fluid boluses (temporary changes in blood pressure or heart rate); the test stops if the anesthesiologist has any safety concerns. There is no direct benefit to participants, but results may help guide fluid therapy for similar patients in the future. The study is being conducted at a single academic hospital in the Republic of Korea and plans to enroll about 300 adults.",[86,87,88,89,90],"Perioperative Care","Fluid Therapy","Monitoring, Physiologic","Hemodynamics","Laparoscopy",[92,93,94,95,96,97],"stroke volume variation; SVV","Pleth Variability Index; PVI","fluid responsiveness","goal-directed fluid therapy; GDFT","pneumoperitoneum","diagnostic accuracy; ROC; AUROC","2026-06-24",{"date":100,"type":101},"2026-06-26","ACTUAL",{"date":103,"type":82},"2026-07-01",{"date":105,"type":82},"2026-08-30",{"name":5,"class":6},1]