[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100634459":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":25,"centralContacts":30,"locations":25,"responsibleParty":36,"collaborators":25,"id":40,"slug":41,"hasResults":42,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":25,"eligibilityCriteria":46,"healthyVolunteers":42,"sex":47,"minAge":48,"maxAge":25,"enrollmentInfo":49,"targetDuration":25,"studyType":52,"phases":53,"briefSummary":55,"conditions":56,"keywords":58,"overallStatus":63,"whyStopped":25,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":25},{"fullName":5,"class":6},"University Hospital Dubrava","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Paracetamol + Ibuprofen + Famotidine","EXPERIMENTAL","Paracetamol and ibuprofen are administered in an alternating regimen over 14 days. Famotidine is given once daily during the same period. Patients on chronic pantoprazole therapy temporarily switch to famotidine during treatment.",[13],"Drug: Paracetamol + Ibuprofen + Famotidine",{"label":15,"type":16,"description":17,"interventionNames":18},"Paracetamol + Ibuprofen (No Famotidine)","ACTIVE_COMPARATOR","Paracetamol and ibuprofen are administered concomitantly over 14 days without the addition of famotidine.",[19],"Drug: Paracetamol + Ibuprofen",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Participants receive alternating doses of paracetamol (1000 mg) and ibuprofen (400 mg) over a 14-day period, together with famotidine 40 mg once daily. Patients on chronic pantoprazole therapy temporarily switch to famotidine during this period.",[9],null,{"type":22,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Paracetamol + Ibuprofen","Participants receive paracetamol (1000 mg) and ibuprofen (400 mg) administered concomitantly over a 14-day period without the addition of famotidine.",[15],[31],{"name":32,"role":33,"phone":34,"phoneExt":25,"email":35},"Marin Glavčić, MD","CONTACT","+385 01 290 2571","mglavcic@kbd.hr",{"type":37,"investigatorFullName":38,"investigatorTitle":39,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Marin Glavčić","Principal Investigator","100634459","paracetamol-and-ibuprofen-with-or-without-famotidine-for-calcific-tendinitis-of-the-shoulder-100634459",false,"NCT07539961","Paracetamol and Ibuprofen With or Without Famotidine for Calcific Tendinitis of the Shoulder","Randomized Controlled Single-Centre Study Evaluating the Efficacy of Therapy With Paracetamol and Ibuprofen, With and Without Famotidine, in the Treatment of Calcific Tendinitis of the Shoulder","Inclusion Criteria:\n\n* Age ≥18 years\n* Clinical history of shoulder pain consistent with calcific tendinitis\n* Presence of calcifications confirmed by shoulder X-ray\n* Ability and willingness to comply with study procedures and follow-up\n* Signed informed consent\n\nExclusion Criteria:\n\n* Known allergy or hypersensitivity to paracetamol, ibuprofen, or famotidine\n* Active gastrointestinal disease contraindicating NSAID use\n* Chronic dual antiplatelet therapy\n* Current use of proton pump inhibitors other than pantoprazole (unless temporarily replaced)\n* Severe systemic diseases that may interfere with study participation or outcomes","ALL","18 Years",{"count":50,"type":51},200,"ESTIMATED","INTERVENTIONAL",[54],"NA","This randomized, open-label, single-centre controlled study evaluates the efficacy and safety of combined paracetamol and ibuprofen therapy with versus without famotidine in the treatment of calcific tendinitis of the shoulder. Outcomes include pain reduction, functional improvement, radiological changes, and need for additional interventions over a 12-month follow-up period.",[57],"Calcific Tendinitis",[59,60,61,62],"Calcific tendinitis","Shoulder pain","NSAIDs","Famotidine","NOT_YET_RECRUITING","2026-04-13",{"date":66,"type":67},"2026-04-20","ACTUAL",{"date":69,"type":51},"2026-09-01",{"date":71,"type":51},"2028-12-31",{"name":5,"class":6}]