[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100562109":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":33,"centralContacts":33,"locations":34,"responsibleParty":54,"collaborators":33,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":33,"eligibilityCriteria":64,"healthyVolunteers":60,"sex":65,"minAge":66,"maxAge":33,"enrollmentInfo":67,"targetDuration":33,"studyType":70,"phases":71,"briefSummary":73,"conditions":74,"keywords":76,"overallStatus":36,"whyStopped":33,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"Chang Gung University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"PD APA training group","EXPERIMENTAL","Weight shift training and APA feedback.",[13],"Procedure: Weight shift training and APA feedback",{"label":15,"type":10,"description":16,"interventionNames":17},"PD PAS group","Using PAS to regulate brain plasticity",[18],"Procedure: Paired associative stimulation",[20,27],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"PROCEDURE","Weight shift training and APA feedback","Use COP trajectory to train weight shift on force plate. To give APA visual feedback for subjects after weight shift training.",[9],[26],"APA training",{"type":21,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"Paired associative stimulation","Use TMS combine ES to stimulate TA nerve and M1 cortical",[15],[32],"PAS training",null,[35],{"facility":5,"status":36,"city":37,"state":33,"zip":38,"country":39,"countryCode":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"RECRUITING","Taoyuan","333","Taiwan","TW",{"type":42,"coordinates":43},"Point",[44,45],121.29696,24.99368,{"lat":45,"lon":44},[48],{"name":49,"role":50,"phone":51,"phoneExt":52,"email":53},"Ya-Ju Chang, PhD","CONTACT","88632118800","5515","yjchang@mail.cgu.edu.tw",{"type":55,"investigatorFullName":56,"investigatorTitle":57,"investigatorAffiliation":5,"oldNameTitle":33,"oldOrganization":33},"PRINCIPAL_INVESTIGATOR","Ya-Ju Chang","Professor","100562109","pas-balance-training-for-parkinson-disease-pd-100562109",false,"NCT06598891","PAS Balance Training for Parkinson Disease (PD)","Effect of Combined PAS Balance Training on Individuals With PD","Inclusion Criteria:\n\n\\- Clinical diagnosis of Parkinson disease.\n\nExclusion Criteria:\n\n* Musculoskeletal injuries on legs\n* Osteoporosis.\n* Any peripheral or central nervous system injury or disease patients.","ALL","20 Years",{"count":68,"type":69},60,"ESTIMATED","INTERVENTIONAL",[72],"NA","Gait initiation (GI) difficulty is a common problem in individuals with Parkinson's disease (PD), often linked to impaired anticipatory postural adjustments (APA). Currently, there are no targeted rehabilitation programs designed specifically for GI-related APA in PD patients. Research has shown that while motor learning deficits are common in PD, explicit learning is better preserved than implicit learning. Therefore, a GI-related APA training system using an explicit learning model could be particularly effective for this population.\n\nDuring motor learning, long-term potentiation (LTP) increases the excitability of the primary motor cortex. Paired associative stimulation (PAS) has been demonstrated to induce LTP-like changes in the motor cortex, making it a potential priming method to enhance motor learning. However, the priming effect of PAS targeted at leg muscles and the motor cortex on motor learning related to GI-APA has not been previously studied.\n\nThe objectives of this study are:\n\n1. To investigate the effects of explicit and implicit training on GI-related APA.\n2. To evaluate the priming effect of PAS on GI-related APA training and the associated plasticity changes in the motor cortex.",[75],"PD - Parkinson's Disease",[77,78,79,80,81],"Gait Initiation","Paired associative stimulation (PAS)","Balance training","Motor learning","Anticipatory postural adjustment (APA)","2024-10-09",{"date":84,"type":85},"2024-10-10","ACTUAL",{"date":82,"type":85},{"date":88,"type":69},"2026-05",{"name":5,"class":6},1]