[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100546091":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":23,"centralContacts":28,"locations":34,"responsibleParty":51,"collaborators":10,"id":53,"slug":54,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":59,"eligibilityCriteria":60,"healthyVolunteers":55,"sex":61,"minAge":62,"maxAge":63,"enrollmentInfo":64,"targetDuration":10,"studyType":67,"phases":10,"briefSummary":68,"conditions":69,"keywords":71,"overallStatus":37,"whyStopped":10,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":84},{"fullName":5,"class":6},"CentraCare","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Fluid responder",null,"Stability of vasopressor dose with maximum of 500 cc of crystalloids",[13],"Diagnostic Test: Passive leg raise, SVI via bioreactance, Echo based VTI",{"label":15,"type":10,"description":16,"interventionNames":10},"Fluid non responder","Escalating dose of vasopressors despite 1 L of crystalloid fluid challenge",[18],{"type":19,"name":20,"description":21,"armGroupLabels":22,"otherNames":10},"DIAGNOSTIC_TEST","Passive leg raise, SVI via bioreactance, Echo based VTI","No interventions other than fluid challenge",[9],[24],{"name":25,"affiliation":26,"role":27},"Ramakanth Pata, MD FCCP","Centracare health System","PRINCIPAL_INVESTIGATOR",[29],{"name":30,"role":31,"phone":32,"phoneExt":10,"email":33},"Ramakanth Pata","CONTACT","320-240-2207","cookybrey1@gmail.com",[35],{"facility":36,"status":37,"city":38,"state":39,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"St Cloud Hospital","RECRUITING","Saint Cloud","Minnesota","56303","United States","US",{"type":44,"coordinates":45},"Point",[46,47],-94.16249,45.5608,{"lat":47,"lon":46},[50],{"name":25,"role":31,"phone":32,"phoneExt":10,"email":33},{"type":27,"investigatorFullName":30,"investigatorTitle":52,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Principal Investigator","100546091","passive-leg-raise-and-mini-fluid-challenge-effect-on-various-cardiac-output-surrogates-for-fluid-responsiveness-100546091",false,"NCT06390423","Passive Leg Raise and Mini-fluid Challenge Effect on Various Cardiac Output Surrogates for Fluid Responsiveness","Passive Leg Raise and Mini-fluid Challenge Effect on Various Cardiac Output Surrogates Such as Pulse Pressure Variation (PPV), End-tidal CO2 (Carbon Dioxide), Bioreactance (Stroke Volume Index -SVI) and Velocity Time Integral on Echocardiographic Exam for Fluid Responsiveness in Patients With Moderately Severe ARDS (Acute Respiratory Distress Syndrome)","PHOENIX","Inclusion Criteria:\n\n* Age between 30 - 90 years\n* Diagnosis of Vasodilatory Shock with no other obvious cause of hypotension\n* Diagnosis of ARDS with PF ratio \\\u003C 150 , PEEP \\> 8\n* Patients who are under paralysis or deeply sedated, on a mechanical ventilator\n\nExclusion Criteria:\n\n* Patients with arrhythmias including atrial fibrillation\n* Patients with chest tube, intra-abdominal hypertension or with its risk factors\n* Patients with structural heart disease including pulmonary hypertension (RVSP \\> 45) and heart failure\n* Patients on extracorporeal support such as ECMO, CRRT or MCS.\n* Patients with COPD with a premorbid FEV1 \\\u003C 1.5 L\n* Severe atherosclerotic vascular disease","ALL","30 Years","90 Years",{"count":65,"type":66},64,"ESTIMATED","OBSERVATIONAL","In the critically ill population, fluid administration in an unstable patient is perhaps the most common intervention that is performed. Uncorrected hypovolemia with inappropriate vasopressors lead to organ hypoperfusion where as overzealous fluid administration especially in ARDS (Adult respiratory distress syndrome) can increase mortality. It has been estimated that only 50% of hemodynamically unstable critically ill patients are volume responsive, hence dynamic assessment of preload responsiveness has been proposed to better identify those individuals who would benefit from fluid bolus.",[70],"Fluid Responsiveness",[72,73,74],"Pre-load responsiveness","Passive leg raise","Mini-fluid challenge","2024-08-20",{"date":77,"type":78},"2024-08-22","ACTUAL",{"date":80,"type":78},"2023-07-01",{"date":82,"type":66},"2025-06",{"name":5,"class":6},1]