[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100605100":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":21,"locations":27,"responsibleParty":45,"collaborators":10,"id":49,"slug":50,"hasResults":51,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":10,"eligibilityCriteria":55,"healthyVolunteers":51,"sex":56,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":62,"studyType":63,"phases":10,"briefSummary":64,"conditions":65,"keywords":67,"overallStatus":74,"whyStopped":10,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":84},{"fullName":5,"class":6},"Recep Tayyip Erdogan University Training and Research Hospital","OTHER",[8,12,15,18],{"label":9,"type":10,"description":11,"interventionNames":10},"No psoriasis severity",null,"Patients with a PASI (Psoriasis Area and Severity Index) score of 0",{"label":13,"type":10,"description":14,"interventionNames":10},"Mild psoriasis severity","Patients with a PASI (Psoriasis Area and Severity Index) score of 1-10",{"label":16,"type":10,"description":17,"interventionNames":10},"Moderate psoriasis severity","Patients with a PASI (Psoriasis Area and Severity Index) score of 10-20",{"label":19,"type":10,"description":20,"interventionNames":10},"Severe psoriasis","Patients with a PASI (Psoriasis Area and Severity Index) score of \\>20",[22],{"name":23,"role":24,"phone":25,"phoneExt":10,"email":26},"Oguz KOSE, Professor Dr.","CONTACT","+90 541 348 64 65","oguz.kose@erdogan.edu.tr",[28],{"facility":29,"status":10,"city":30,"state":31,"zip":32,"country":33,"countryCode":10,"cosmosGeoPoint":34,"geoPoint":39,"contacts":40},"Department of Periodontology of the Faculty of Dentistry of Recep Tayyip Erdogan University","Rize","Rize Province","53200","Turkey (Türkiye)",{"type":35,"coordinates":36},"Point",[37,38],40.52194,41.02083,{"lat":38,"lon":37},[41],{"name":42,"role":24,"phone":43,"phoneExt":10,"email":44},"RTEU Faculty of Dentistry, Department of Periodontology","+90 464 222 00 00","dis@erdogan.edu.tr",{"type":46,"investigatorFullName":47,"investigatorTitle":48,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Dilek KARADOĞAN","Assoc. Prof. Dr.","100605100","pathogenesis-of-periodontal-disease-in-individuals-with-psoriasis-100605100",false,"NCT07158125","Pathogenesis of Periodontal Disease in Individuals With Psoriasis","Role of Th17 and Stress-related Neuroendocrine Markers in the Pathogenesis of Periodontal Disease in Individuals With Psoriasis","Inclusion Criteria:\n\n* Being between the ages of 18 and 65\n* Being diagnosed with psoriasis by a dermatologist\n* Having at least 20 teeth\n* Not having received periodontal treatment in the last 6 months\n* Not having taken antibiotics, steroids, and\u002For nonsteroidal anti-inflammatory drugs in the last 3 weeks\n* Not having any autoimmune disease, osteoporosis, or cancer\n* Not using immunosuppressive drugs, oral contraceptives, or bisphosphonates\n* Not being pregnant\n* Not having an active infectious disease (acute hepatitis, tuberculosis, AIDS)\n* Not using chronic medications that affect periodontal tissues (cyclosporine A, phenytoin)\n* Not having taken antioxidant supplements in the last 6 months\n\nExclusion Criteria:\n\n* \\\u003C20 teeth\n* Any significant oral infection (i.e., herpes or candidiasis)\n* Oral injuries or bleeding unrelated to periodontitis\n* Periodontal therapy and antibiotic therapy within the past 3 months\n* Salivary gland dysfunction\n* Acute illness (fever, sore throat)\n* Systemic illness, mental illness, immunosuppressive drugs or immunodeficiency\n* Pregnancy or breastfeeding\n* Use of antidepressants","ALL","18 Years","65 Years",{"count":60,"type":61},60,"ESTIMATED","1 Day","OBSERVATIONAL","The aim of this study is to evaluate the levels of Th17 cell-associated cytokines (IL-17, IL-21, IL-23) and the salivary stress biomarkers cortisol, dehydroepiandrosterone, and Chromogranin A in the pathogenesis of periodontal disease in individuals with psoriasis, thereby revealing immunological and neuroendocrine interactions.\n\nThe fundamental question it aims to answer is:\n\nWhat are the biological mechanisms that may increase the risk of periodontal disease in individuals with psoriasis?\n\nIn this context, the periodontal status of individuals with psoriasis will be clinically assessed, followed by analysis of the levels of Th17-associated cytokines and stress biomarkers in gingival crevicular fluid and saliva samples. Additionally, patients will be asked questions from the Social Appearance Anxiety Scale. The periodontal status of individuals with psoriasis will be determined cross-sectionally, and the resulting biomarker levels will be examined. In addition, the data obtained will be evaluated with statistical analysis in relation to disease severity and clinical parameters.",[66],"Psoriasis",[68,69,70,71,72,73],"psoriasis","periodontitis","Th17","cortisol","dehydroepiandrosterone","chromogranin A","NOT_YET_RECRUITING","2025-08-28",{"date":77,"type":78},"2025-09-05","ACTUAL",{"date":80,"type":61},"2025-09-15",{"date":82,"type":61},"2026-04-06",{"name":5,"class":6},1]