[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100594101":3},{"organization":4,"armGroups":7,"interventions":13,"overallOfficials":18,"centralContacts":22,"locations":10,"responsibleParty":28,"collaborators":10,"id":30,"slug":31,"hasResults":32,"nctId":33,"briefTitle":34,"officialTitle":34,"acronym":10,"eligibilityCriteria":35,"healthyVolunteers":36,"sex":37,"minAge":38,"maxAge":39,"enrollmentInfo":40,"targetDuration":10,"studyType":43,"phases":44,"briefSummary":46,"conditions":47,"keywords":10,"overallStatus":49,"whyStopped":10,"lastUpdateSubmitDate":50,"lastUpdatePostDateStruct":51,"startDateStruct":54,"completionDateStruct":56,"leadSponsor":58,"locationsCount":10},{"fullName":5,"class":6},"Université Catholique de Louvain","OTHER",[8],{"label":9,"type":6,"description":10,"interventionNames":11},"PathSSc",null,[12],"Procedure: cutaneous biospy",[14],{"type":15,"name":16,"description":16,"armGroupLabels":17,"otherNames":10},"PROCEDURE","cutaneous biospy",[9],[19],{"name":20,"affiliation":5,"role":21},"Nisha Limaye, PhD","STUDY_DIRECTOR",[23],{"name":24,"role":25,"phone":26,"phoneExt":10,"email":27},"Farah Tamirou, Pr","CONTACT","+32 2 674 53 87","farah.tamirou@saintluc.uclouvain.be",{"type":29,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100594101","pathogenic-mechanisms-involved-in-the-initiation-and-progression-of-systemic-sclerosis-100594101",false,"NCT07015060","Pathogenic Mechanisms Involved in the Initiation and Progression of Systemic Sclerosis","Inclusion Criteria:\n\n* Patients diagnosed with one of the following:\n\n  * Limited SSc\n  * Limited cutaneous SSc\n  * Diffuse cutaneous SSc\n* Patients followed regularly in consultations at CUSL.\n* Patients between ages 18-80.\n\nExclusion Criteria:\n\n* Other (co-occurring) autoimmune\u002Fautoinflammatory disease\n* Pregnancy\n* Participants with temporary or definitive disabilities to give consent\n* Participants unable to sign or read the inform consent form",true,"ALL","18 Years","80 Years",{"count":41,"type":42},15,"ESTIMATED","INTERVENTIONAL",[45],"NA","Identify rare variants in candidate genes and pathways identified in familial SSc, in patients with sporadic SSc.\n\nPerform (spatial) transcriptomic and proteomic analyses of affected skin from patients with and without cutaneous fibrosis, for the patterns and levels of expression\u002Factivation of candidate genes and pathways.\n\nTest for dysregulation of expression\u002Factivation of candidate genes and pathways in live cells isolated from the blood and skin biopsy of patients, and for the impact of these dysregulations on cell appearance, behavior and function.",[48],"Scleroderma (Limited and Diffuse)","NOT_YET_RECRUITING","2025-06-02",{"date":52,"type":53},"2025-06-11","ACTUAL",{"date":55,"type":42},"2025-06",{"date":57,"type":42},"2031-03",{"name":5,"class":6}]