[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100562012":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":26,"locations":31,"responsibleParty":51,"collaborators":10,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":10,"eligibilityCriteria":61,"healthyVolunteers":57,"sex":62,"minAge":63,"maxAge":64,"enrollmentInfo":65,"targetDuration":10,"studyType":68,"phases":10,"briefSummary":69,"conditions":70,"keywords":72,"overallStatus":34,"whyStopped":10,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":84},{"fullName":5,"class":6},"Chongqing Medical University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"unilateral primary aldosteronism group",null,"The patient was diagnosed with unilateral primary aldosteronism and underwent total adrenal resection",[13],"Other: Tissue specimens were stained by histopathology of hematoxylin-eosin",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":19},"Tissue specimens were stained by histopathology of hematoxylin-eosin","Whole slide images were created by scanning the complete histologic slide to produce high-resolution digital files of the histopathology of hematoxylin-eosin and CYP11B2 immunostained sections.Tissue sections of all blocks from each resected adrenal were evaluated by hematoxylin and eosin and CYP11B2 immunostaining and adrenal specimens were categorized as classical or nonclassical histopathologic findings of unilateral PA according to the HISTALDO consensus; Genotyping was performed using CYP11B2 (aldosterone synthase)-guided sequencing",[9],[20],"Tissue specimens were stained by CYP11B2",[22],{"name":23,"affiliation":24,"role":25},"Li Qifu","First Affiliated Hospital of Chongqing Medical University","STUDY_CHAIR",[27],{"name":23,"role":28,"phone":29,"phoneExt":10,"email":30},"CONTACT","02389011552","liqifu@yeah.net",[32],{"facility":33,"status":34,"city":35,"state":36,"zip":37,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"Qifu Li, PhD","RECRUITING","Chongqing","Chongqing Municipality","400016","China","CN",{"type":41,"coordinates":42},"Point",[43,44],106.55771,29.56026,{"lat":44,"lon":43},[47],{"name":48,"role":28,"phone":49,"phoneExt":50,"email":30},"Li Qifu, PhD","18696676815","+86",{"type":52,"investigatorFullName":53,"investigatorTitle":54,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"SPONSOR_INVESTIGATOR","Qifu Li","Primary investigator","100562012","pathological-typegene-mutation-and-clinical-characteristics-of-unilateral-primary-aldosteronism-100562012",false,"NCT06597630","Pathological Type，Gene Mutation and Clinical Characteristics of Unilateral Primary Aldosteronism","Pathological Type，Gene Mutation and Clinical Characteristics of Unilateral Primary Aldosteronism，A Prospective Study","Inclusion Criteria:\n\n1. No gender limitation;\n2. Age 18-80 years old;\n3. The patient was diagnosed with UPA and underwent total adrenal resection.\n\nExclusion Criteria:\n\n1. Bilateral disease\n2. Partial of no biochemical response in follow-up\n3. partial adrenalectomy","ALL","18 Years","80 Years",{"count":66,"type":67},100,"ESTIMATED","OBSERVATIONAL","1. Aim to investigate the pathological feature of UPA in Asians\n2. To clarify the relationship between pathology, clinical phenotype, genetic mutation and surgical outcome of UPA in Asians.\n3. To explore a new pathological type of unilateral primary aldosterone",[71],"Primary Aldosteronism",[73,74],"Pathological type","Gene mutation","2024-09-13",{"date":77,"type":78},"2024-09-19","ACTUAL",{"date":80,"type":78},"2023-12-01",{"date":82,"type":67},"2024-12-31",{"name":53,"class":6},1]