[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100535586":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":23,"centralContacts":27,"locations":34,"responsibleParty":51,"collaborators":53,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":63,"eligibilityCriteria":64,"healthyVolunteers":59,"sex":65,"minAge":66,"maxAge":67,"enrollmentInfo":68,"targetDuration":10,"studyType":71,"phases":10,"briefSummary":72,"conditions":73,"keywords":75,"overallStatus":37,"whyStopped":10,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"Umeå University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Postdural puncture headache after lumbar puncture",null,"Group of patients with aged 20-40 years undergoing planned neurological work-up including a lumbar puncture (LP). The group will include 40 subjects with and 40 subjects without PDPH.",[13],"Other: MRI examination",{"label":15,"type":10,"description":16,"interventionNames":17},"Postdural puncture headache after accidental dural puncture","Group of parturients with EDA. The group will include 40 subjects with accidental dural puncture (ADP) with PDPH and 40 subjects without ADP and PDPH.",[13],[19],{"type":6,"name":20,"description":21,"armGroupLabels":22,"otherNames":10},"MRI examination","All included subjects will be examined with MRI",[15,9],[24],{"name":25,"affiliation":5,"role":26},"Laleh Zarrinkoob, MD, PhD","PRINCIPAL_INVESTIGATOR",[28],{"name":29,"role":30,"phone":31,"phoneExt":32,"email":33},"Erik Burman, MD","CONTACT","907864594","+46","erik.burman@regionvasterbotten.se",[35],{"facility":36,"status":37,"city":38,"state":39,"zip":10,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"Umeå University Hospital","RECRUITING","Umeå","Västerbotten County","Sweden","SE",{"type":43,"coordinates":44},"Point",[45,46],20.25972,63.82842,{"lat":46,"lon":45},[49],{"name":25,"role":30,"phone":31,"phoneExt":32,"email":50},"laleh.zarrinkoob@umu.se",{"type":52,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[54],{"name":55,"class":56},"Region Västerbotten","OTHER_GOV","100535586","pathophysiological-mechanisms-and-implication-of-treatment-in-postural-puncture-headache-100535586",false,"NCT06253754","Pathophysiological Mechanisms and Implication of Treatment in Postural Puncture Headache","Cerebral Hemodynamics and Cerebrospinal Fluid Dynamics in Postdural Puncture Headache An MRI Study for Exploring the Pathophysiological Mechanisms and Implication of Treatment","PDPH","Inclusion Criteria:\n\nPostural puncture headache Age 20-40\n\nExclusion Criteria:\n\n* Other central neurological disorders except the actual\n* Acute medical condition\n* Pregnancy\n* Pacemaker, or other medical implants that are not MRI-compatible\n* Invasive procedures on the central nervous system or surgery on the spine or brain in the last 12 months.","ALL","20 Years","40 Years",{"count":69,"type":70},160,"ESTIMATED","OBSERVATIONAL","To improve treatment for post dural puncture headache, its pathophysiology needs to be explored. Dural puncture alters CNS dynamics; using advanced MRI, we aim to investigate PDPHs pathophysiology explained by brain movement, cerebral blood flow, CSF dynamics and the effect of epidural blood patch.",[74],"Post-Dural Puncture Headache",[76,77,78],"MRI","Cerebral blood flow","Cerebrospinal fluid","2024-02-09",{"date":81,"type":82},"2024-02-12","ACTUAL",{"date":84,"type":82},"2024-01-30",{"date":86,"type":70},"2027-12-28",{"name":5,"class":6},1]