[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100318198":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":24,"centralContacts":29,"locations":37,"responsibleParty":54,"collaborators":10,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":10,"eligibilityCriteria":63,"healthyVolunteers":64,"sex":65,"minAge":10,"maxAge":10,"enrollmentInfo":66,"targetDuration":10,"studyType":69,"phases":10,"briefSummary":70,"conditions":71,"keywords":10,"overallStatus":40,"whyStopped":10,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":82},{"fullName":5,"class":6},"University of Zurich","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Patient",null,"Patients with Primary Immunodeficiency",[13],"Diagnostic Test: Diagnostic Test",{"label":15,"type":10,"description":16,"interventionNames":17},"Control","Healthy Controls",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":10},"DIAGNOSTIC_TEST","Diagnostic Test","Characterisation of cellular and functional phenotype in different PIDs",[15,9],[25],{"name":26,"affiliation":27,"role":28},"Janine Reichenbach, Prof. Dr.","University Children's Hospital, Zurich","PRINCIPAL_INVESTIGATOR",[30,34],{"name":26,"role":31,"phone":32,"phoneExt":10,"email":33},"CONTACT","+41442667311","janine.reichenbach@kispi.uzh.ch",{"name":35,"role":31,"phone":32,"phoneExt":10,"email":36},"Ulrich Siler, PD Dr.","ulrich.siler@kispi.uzh.ch",[38],{"facility":39,"status":40,"city":41,"state":10,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"University Children's Hospital Zurich","RECRUITING","Zurich","8032","Switzerland","CH",{"type":46,"coordinates":47},"Point",[48,49],8.55,47.36667,{"lat":49,"lon":48},[52,53],{"name":26,"role":31,"phone":32,"phoneExt":10,"email":33},{"name":35,"role":31,"phone":32,"phoneExt":10,"email":36},{"type":28,"investigatorFullName":55,"investigatorTitle":56,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Janine Reichenbach","Co-Head Division Immunology","100318198","pathophysiology-of-inborn-immunodeficiencies-100318198",false,"NCT03422614","Pathophysiology of Inborn Immunodeficiencies","Pathophysiologie Angeborener Immundefekte","Inclusion Criteria:\n\n* Clinical diagnosis of an inborn error of immunity (primary immunodeficiency, PID)\n* Clinically healthy (non-age matched) volunteer\n\nExclusion Criteria:\n\n* exclusion of an inborn error of immunity\n* secondary immunodeficiency\n* refusal to enter the study",true,"ALL",{"count":67,"type":68},300,"ESTIMATED","OBSERVATIONAL","The pathophysiology of primary immunodeficiencies (PID), which encompass a broad range of different diseases with susceptibility to infection and\u002For a deregulated inflammatory response, is poorly understood. Available treatments are often not specific for a distinct target and might be associated with side effects. To elucidate pathophysiology of different PIDs, stool, urine, blood, tissue biopsies and\u002For bone marrow will be collected and analysed for anti-microbial activity and inflammatory response. In a second step, targeted treatment for different PIDs might be developed preclinically and ex vivo according to underlying pathophysiology.",[72],"Primary Immune Deficiency Disorder","2026-05-05",{"date":75,"type":76},"2026-05-06","ACTUAL",{"date":78,"type":76},"2015-03-01",{"date":80,"type":68},"2033-03-30",{"name":5,"class":6},1]