[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100488976":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":10,"centralContacts":22,"locations":32,"responsibleParty":49,"collaborators":53,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":10,"eligibilityCriteria":64,"healthyVolunteers":60,"sex":65,"minAge":66,"maxAge":67,"enrollmentInfo":68,"targetDuration":71,"studyType":72,"phases":10,"briefSummary":73,"conditions":74,"keywords":77,"overallStatus":34,"whyStopped":10,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"Peking University People's Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Set of training",null,"A total of 148 patients with endometrial cancer and atypical endometrial hyperplasia were included in the training set of the prediction model. They were divided into progesterone sensitive group and progesterone insensitive group.",[13],"Other: No intervention",{"label":15,"type":10,"description":16,"interventionNames":17},"Set of verification","A verification set of the prediction model was established, consisting of 96 patients with endometrial cancer and atypical endometrial hyperplasia.",[13],[19],{"type":6,"name":20,"description":20,"armGroupLabels":21,"otherNames":10},"No intervention",[9,15],[23,28],{"name":24,"role":25,"phone":26,"phoneExt":10,"email":27},"WANG JIANLIU, PhD\u002FMD","CONTACT","8601088324383","wangjianliu1203@163.com",{"name":29,"role":25,"phone":30,"phoneExt":10,"email":31},"HE YIJIAO, PhD","+8618301512017","heyijiao2017@pku.edu.cn",[33],{"facility":5,"status":34,"city":35,"state":36,"zip":10,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"RECRUITING","Beijing","Beijing Municipality","China","CN",{"type":40,"coordinates":41},"Point",[42,43],116.39723,39.9075,{"lat":43,"lon":42},[46],{"name":47,"role":25,"phone":48,"phoneExt":10,"email":27},"WANG JIANLIU, PHD\u002FMD","+86108832438",{"type":50,"investigatorFullName":51,"investigatorTitle":52,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Wang Jianliu","Professor, Doctoral supervisor, Chief physician, Vice President",[54,56],{"name":55,"class":6},"Peking University",{"name":57,"class":6},"Beihang University","100488976","patient-derived-tumor-like-cell-clusters-predict-progesterone-sensitivity-in-patients-with-early-endometrial-cancer-100488976",false,"NCT05647109","Patient-derived Tumor-like Cell Clusters Predict Progesterone Sensitivity in Patients With Early Endometrial Cancer","Department of Obstetrics & Gynecology ，Peking University People's Hospital","Inclusion Criteria:\n\n* Have a confirmed pathological diagnosis based upon hysteroscopy: atypical endometrial hyperplasia or histologically prove well-differentiated EEC G1 without myometrial invasion\n* No signs of suspicious extrauterine involvement on enhanced magnetic resonance imaging (MRI) or enhanced computed tomography (CT) or ultrasound\n* Have a desire for remaining reproductive function or uterus\n* Good compliance with adjunctive treatment and follow-up\n\nExclusion Criteria:\n\n* Acute liver disease or liver tumor (benign or malignant) or renal dysfunction\n* Pregnancy or potential pregnancy\n* Confirmed diagnosis of any cancer in reproductive system\n* Acute severe disease such as stroke or heart infarction or a history of thrombosis disease\n* Hypersensitivity or contradiction for using MPA or MA\n* With other factors of reproductive dysfunction;\n* Strong request for uterine removal or other conservative treatment","FEMALE","17 Years","45 Years",{"count":69,"type":70},244,"ESTIMATED","1 Year","OBSERVATIONAL","To construct a prediction model of progesterone sensitivity in patients with endometrial cancer treated with fertility preservation",[75,76],"Endometrial Carcinoma Stage I","Atypical Endometrial Hyperplasia",[78,79,80],"Progesterone","Patient-derived tumor-like cell clusters","Endometrial Carcinoma","2025-05-02",{"date":83,"type":84},"2025-05-04","ACTUAL",{"date":86,"type":84},"2021-09-01",{"date":88,"type":70},"2025-10-31",{"name":5,"class":6},1]