[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100617994":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":22,"centralContacts":32,"locations":41,"responsibleParty":58,"collaborators":61,"id":72,"slug":73,"hasResults":74,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":78,"eligibilityCriteria":79,"healthyVolunteers":74,"sex":80,"minAge":81,"maxAge":10,"enrollmentInfo":82,"targetDuration":85,"studyType":86,"phases":10,"briefSummary":87,"conditions":88,"keywords":94,"overallStatus":106,"whyStopped":10,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":116},{"fullName":5,"class":6},"Dr. Negrin University Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Ozone Group",null,"Patients with refractory symptoms referred for palliative treatment with ozone therapy between 2026 and 2029.",[13],"Procedure: Ozone Therapy",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"PROCEDURE","Ozone Therapy","Systemic (rectal, autohemotherapy) and\u002For local ozone administration (cutaneous, intravaginal, intravesical). Dosage, frequency, and duration will depend on the symptoms treated and clinical evolution. Usually planned 40 sessions over 4 months.",[9],[21],"Ozone Treatment",[23,27,30],{"name":24,"affiliation":25,"role":26},"Bernardino Clavo, MD, PhD","Dr. Negrín University Hospital, Las Palmas, Spain","STUDY_CHAIR",{"name":28,"affiliation":25,"role":29},"Francisco Rodríguez-Esparragón, BSc, PhyD","PRINCIPAL_INVESTIGATOR",{"name":31,"affiliation":25,"role":29},"Ángeles Cánovas-Molina, RN",[33,38],{"name":34,"role":35,"phone":36,"phoneExt":10,"email":37},"Bernardino Clavo, MD, PhD.","CONTACT","+34 928449278","bernardinoclavo@gmail.com",{"name":28,"role":35,"phone":39,"phoneExt":10,"email":40},"+34 928449288","afrodesp@gmail.com",[42],{"facility":43,"status":10,"city":44,"state":45,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"Dr. Negrín University Hospital","Las Palmas de Gran Canaria","Las Palmas","35019","Spain","ES",{"type":50,"coordinates":51},"Point",[52,53],-15.41573,28.10178,{"lat":53,"lon":52},[56,57],{"name":24,"role":35,"phone":36,"phoneExt":10,"email":37},{"name":28,"role":35,"phone":39,"phoneExt":10,"email":40},{"type":59,"investigatorFullName":24,"investigatorTitle":60,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"SPONSOR_INVESTIGATOR","Principal Investigator, Research Unit Director",[62,63,65,68,70],{"name":5,"class":6},{"name":64,"class":6},"Fundación Canaria Instituto de Investigación Sanitaria de Canarias",{"name":66,"class":67},"Complejo Hospitalario Universitario Insular Materno Infantil (CHUIMI)","UNKNOWN",{"name":69,"class":67},"Instituto Universitario de Microelectrónica Aplicada de la Universidad de Las Palmas de Gran Canaria (IUMA-ULPGC)",{"name":71,"class":6},"Council of Gran Canaria","100617994","patients-referred-to-the-chronic-pain-unit-for-palliative-treatment-with-ozone-therapy-between-2026-and-2029-100617994",false,"NCT07325851","Patients Referred to the Chronic Pain Unit for Palliative Treatment With Ozone Therapy Between 2026 and 2029.","Prospective and Observational Study of Patients Referred to the Chronic Pain Unit for Palliative Treatment With Ozone Therapy Between 2026 and 2029. Prospective Study EPOOzo-2.","EPOOzo-2","Inclusion Criteria:\n\n* 1\\. Adults ≥ 18 years old.\n* 2\\. Patients referred to the Chronic Pain Unit of the Dr. Negrín University Hospital for symptomatic\u002Fpalliative treatment with ozone therapy because conventional treatment does not exist, has failed, has offered insufficient results, or is associated with high risk\u002Fmorbidity.\n* 3\\. After evaluation of symptoms and patients, it exists a potential benefit of adding ozone treatment to the current treatment.\n* 4\\. Patients have no contraindications for ozone treatment.\n* 5\\. Patients must sign the specific Informed Consent for this study and for the ozone treatment.\n\nExclusion Criteria:\n\n* 1\\. Age \\\u003C 18 years old.\n* 2\\. Psychiatric illness or social situations that would limit compliance with study requirements.\n\nContraindication or disability to attend scheduled treatments.\n\n* 3\\. Contraindication or disability to attend scheduled treatments.\n* 4\\. Uncontrolled clinical conditions (e.g., severe heart failure, massive hemorrhage, status epilepticus).\n* 5\\. Life expectancy \\\u003C 6 months.\n* 6\\. Known allergy to ozone.\n* 7\\. Hemochromatosis (for systemic ozone treatment).\n* 8\\. Pregnancy (for systemic ozone treatment).\n* 9\\. Significant Glucose-6-Phosphate Dehydrogenase deficiency (Favism) (for systemic ozone treatment).\n* 10\\. Patients who do not meet the inclusion criteria.","ALL","18 Years",{"count":83,"type":84},120,"ESTIMATED","40 Weeks","OBSERVATIONAL","The main objective of this study is to analyze the impact on the health-related quality of life of patients with refractory symptoms who have been referred to the Dr. Negrín University Hospital Chronic Pain Unit for adjuvant palliative treatment with ozone therapy between January 2026 and December 2029. Additionally, the study aims to evaluate several specific symptoms, hyperspectral and thermal images, non-invasive clinical parameters related to the Autonomic Nervous System (such as heart rate variability, electrochemical skin conductance, and vibration perception thresholds), oxidative stress and inflammatory parameters, and gut microbiota composition.",[89,90,91,92,93],"Chemotherapy-Induced Peripheral Neuropathy","Radiation Toxicity","Chronic Pain","Delayed Wound Healing","Refractory Symptoms",[17,95,96,97,98,99,100,101,102,103,104,105],"Health-related quality of life","Chemotherapy-induced Peripheral Neuropathy","Radiation-induced toxicity","Hyperspectral imaging","Infrared imaging","Heart Rate Variability","Sudoscan","Vibrometry","Oxidative stress","Gut Microbiota","Anxiety and Depression","NOT_YET_RECRUITING","2025-12-23",{"date":109,"type":110},"2026-01-08","ACTUAL",{"date":112,"type":84},"2026-01-14",{"date":114,"type":84},"2030-06-30",{"name":24,"class":6},1]