[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100559007":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":33,"centralContacts":38,"locations":43,"responsibleParty":61,"collaborators":32,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":69,"eligibilityCriteria":70,"healthyVolunteers":65,"sex":71,"minAge":72,"maxAge":73,"enrollmentInfo":74,"targetDuration":32,"studyType":77,"phases":78,"briefSummary":80,"conditions":81,"keywords":83,"overallStatus":46,"whyStopped":32,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Pectin intervention group","EXPERIMENTAL","This group will orally take 10 g of apple pectin (DE 57%) + 5 g of maltodextrin once a day during 6 months.",[13],"Dietary Supplement: Apple pectin (DE 57%)",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo group","PLACEBO_COMPARATOR","This group will orally take 5 g of maltodextrin once a day during 6 months.",[19],"Dietary Supplement: Placebo",[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DIETARY_SUPPLEMENT","Apple pectin (DE 57%)","Dietary intervention with apple pectin. Participants will orally take the supplement once a day, after dissolving it in 100 ml of water, for 6 months.",[9],[27],"Herbapekt",{"type":22,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"Placebo","Dietary intervention with maltodextrin. Participants will orally take the placebo (maltodextrin) once a day, after dissolving it in 100ml of water, for 6 months.",[15],null,[34],{"name":35,"affiliation":36,"role":37},"Natalia Pérez Sánchez, MD, PhD","Allergy Clinical Unit, Hospital Regional Universitario de Málaga, Málaga, Spain","PRINCIPAL_INVESTIGATOR",[39],{"name":35,"role":40,"phone":41,"phoneExt":32,"email":42},"CONTACT","+34 951290224","nataliai.perez.sspa@juntadeandalucia.es",[44],{"facility":45,"status":46,"city":47,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"Hospital Regional Universitario de Málaga","RECRUITING","Málaga","29009","Spain","ES",{"type":52,"coordinates":53},"Point",[54,55],-4.42034,36.72016,{"lat":55,"lon":54},[58],{"name":59,"role":40,"phone":60,"phoneExt":32,"email":42},"Natalia Pérez, Dr.","+34951290224",{"type":62,"investigatorFullName":32,"investigatorTitle":32,"investigatorAffiliation":32,"oldNameTitle":32,"oldOrganization":32},"SPONSOR","100559007","pectin-intervention-study-and-long-term-follow-up-in-lipid-transfer-proteins-allergic-patients-100559007",false,"NCT06558526","Pectin Intervention Study and Long-term Follow-up in Lipid Transfer Proteins Allergic Patients","Analysis of the Clinical Efficacy and Immunomodulatory Effect of Pectin in LTP Allergic Patients Through a Placebo-controlled Intervention Study and Long-term Follow-up","PI23\u002F00820","Inclusion Criteria:\n\n* Adults with a clear clinical history of food allergy after eating peach (oral allergy syndrome and\u002For systemic symptoms) and with or without clinical history of food allergy with peanut.\n* Sensitization to Pru p 3 by positive skin prick test (SPT wheal area \\>7 mm2) and specific IgE (sIgE \\>0.35 kUA\u002FL)\n* Positive DBPCFC with peach juice.\n* If clinical history of food allergy with peanut, sensitization must be confirmed by positive SPT to peanut and sIgE \\>0.35 kUA\u002FL to Ara h 9 and clinical reactivity through a positive DBPCFC with peanut.\n* Signed informed consent.\n\nExclusion Criteria:\n\n* Food allergy to corn.\n* Food allergy to peanut due to sensitization to storage proteins.\n* Previous\u002Factive treatment with sublingual immunotherapy to Pru p 3.\n* Pregnancy\u002Flactation.\n* Active infections.\n* Inflammatory, autoimmune, and\u002For oncological diseases.\n* Severe immunodeficiency.\n* Metabolic syndrome.\n* Increased liver parameters and\u002For any liver disease.\n* Alcohol disorder.\n* Mental illness.\n* Mast cell activation syndrome.\n* Severe atopic dermatitis.\n* FEV1 \\\u003C 70%\n* Treatment with immunomodulators in the last five years.\n* Vitamin supplements, probiotics, prebiotics, antibiotics, metformin, statins, proton pump inhibitors, or corticosteroids in the last three months.\n* Any clinical condition contraindicating performance of DBPCFC.","ALL","18 Years","60 Years",{"count":75,"type":76},62,"ESTIMATED","INTERVENTIONAL",[79],"NA","Pectins are dietary fibers that have shown a health effect on patients with food allergy, as they are capable of modifying the composition of gastrointestinal microbiota, and producing an immunomodulatory effect. Preliminary results by the investigators show that the intervention for 2 months with pectins produces an increase in tolerance to peach, and changes in the microbiota compared to the group of patients treated with placebo. In this project, the investigators aim to study these clinical effects and the involved mechanisms. Moreover, the long-term effect (clinical reactivity to nsLTP and immunomodulatory effect) of the dietary intervention will be prospectively evaluated 6 months after the intervention.",[82],"Food Allergy",[84,85,86,87,88,89],"nsLTP allergy","Dietary intervention","Pectin","Microbiome","Immunomodulation","Food allergy treatment","2025-06-11",{"date":92,"type":93},"2025-06-15","ACTUAL",{"date":95,"type":93},"2025-01-13",{"date":97,"type":76},"2026-11-30",{"name":5,"class":6},1]