[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100545385":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":28,"centralContacts":36,"locations":45,"responsibleParty":64,"collaborators":23,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":71,"acronym":23,"eligibilityCriteria":72,"healthyVolunteers":69,"sex":73,"minAge":74,"maxAge":75,"enrollmentInfo":76,"targetDuration":23,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":23,"overallStatus":48,"whyStopped":23,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"Universitaire Ziekenhuizen KU Leuven","OTHER",[8,13],{"label":9,"type":6,"description":10,"interventionNames":11},"Cow's milk allergen heat denaturation","Children with an EoE in remission AND a previous diet excluding any form of cow's milk will undergo an oral food challenge with extensively heated cow's milk (20'). Afterwards they will be instructed to ensure regular intake of 20' heated cow's milk. After 8 weeks of (re)introduction they will be assessed for potential remaining remission (\\\u003C15 eosinophils\u002Fhpf on esophagal biopsies). If remission is sustained, they will sequentially decrease the degree of heat denaturation by decreasing the cooking time: 15', 10' and 5' cooked cow's milk. At the end, parents will have the choice to add a final step of raw cow's milk. After every 8 weeks of every new step, a gastroscopy will be performed to assess maintained remission. If remission is lost, they will go back to a strict avoidance diet for at least 10 weeks.",[12],"Other: Implementation of cow's milk in decreasingly heated forms",{"label":14,"type":6,"description":15,"interventionNames":16},"Hen's egg allergen heat denaturation","Children with an EoE in remission AND a previous diet excluding any form of hen's egg will undergo an oral food challenge with strongly heated hen's egg (in cake). Afterwards they will be instructed to ensure regular intake of cake. After 8 weeks of (re)introduction they will be assessed for potential remaining remission (\\\u003C15 eosinophils\u002Fhpf on esophagal biopsies). If remission is sustained, they will sequentially decrease the degree of heat denaturation as follows: hard-boiled egg, omelet and soft-boiled egg. At the end, parents will have the choice to add a final step of raw egg. After every 8 weeks of every new step, a gastroscopy will be performed to assess maintained remission. If remission is lost, they will go back to a strict avoidance diet for at least 10 weeks.",[17],"Other: Implementation of hen's egg in decreasingly heated forms",[19,24],{"type":6,"name":20,"description":21,"armGroupLabels":22,"otherNames":23},"Implementation of cow's milk in decreasingly heated forms","Implementation of cow's milk in decreasingly heated forms to assess maintained remission of EoE",[9],null,{"type":6,"name":25,"description":26,"armGroupLabels":27,"otherNames":23},"Implementation of hen's egg in decreasingly heated forms","Implementation of hen's egg in decreasingly heated forms to assess maintained remission of EoE",[14],[29,33],{"name":30,"affiliation":31,"role":32},"Ilse Hoffman, Prof. Dr.","Co-investigator, pediatric gastro-enterology","PRINCIPAL_INVESTIGATOR",{"name":34,"affiliation":35,"role":32},"Gert De Hertogh, Prof. Dr.","Co-investigator, pathological anatomy",[37,42],{"name":38,"role":39,"phone":40,"phoneExt":23,"email":41},"Dominique Bullens, Prof. Dr.","CONTACT","0032016343801","dominique.bullens@kuleuven.be",{"name":43,"role":39,"phone":40,"phoneExt":23,"email":44},"Marleen Jannis","marleen.jannis@uzleuven.be",[46],{"facility":47,"status":48,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"UZ Leuven Gasthuisberg","RECRUITING","Leuven","Vlaams-Brabant","3000","Belgium","BE",{"type":55,"coordinates":56},"Point",[57,58],4.70093,50.87959,{"lat":58,"lon":57},[61,63],{"name":38,"role":39,"phone":62,"phoneExt":23,"email":41},"0032 16 34 38 01",{"name":43,"role":39,"phone":62,"phoneExt":23,"email":44},{"type":32,"investigatorFullName":65,"investigatorTitle":66,"investigatorAffiliation":5,"oldNameTitle":23,"oldOrganization":23},"Dominque Bullens","Clinic Head in Pediatrics-Allergy at UZ Leuven, Head of the Allergy and Clinical Immunology Research group at KU Leuven (prof., dr.)","100545385","pediatric-eosinophilic-esophagitis-pedeoe-effect-of-allergen-heat-denaturation-on-eoe-remission-a-pilot-trial-100545385",false,"NCT06381219","Pediatric Eosinophilic Esophagitis (pedEoE): Effect of Allergen Heat Denaturation on EoE Remission: a Pilot Trial","Inclusion Criteria:\n\nAll children (aged 12 months and older) presenting (since 1-1-2014: moment of diagnostic guideline standardization for pedEoE) with diagnosed pedEoE at UZ Leuven eliminating either hen's egg or cow's milk or both and in complete remission after their latest biopsy (no longer than 12 months earlier, but preferentially as short as possible after their latest biopsy) are eligible for the study. If the last biopsy has been performed more than 12 months earlier, a new gastro-duodenoscopy will be performed to verify remission and rule out e.g. active gastritis. If they are on PPI and\u002For local budesonide treatment, this should be stable for at least 3 months and will remain untouched during the entire study. We will include 18 pedEoE subjects suffering from cow's milk induced EoE and 18 suffering from hen's egg induced EoE.\n\nExclusion Criteria:\n\n* Children younger than 12 months\n* Children with active pedEoE\n* Children who refuse to adhere to the protocol\n* Children with associated IgE mediated hen's egg and\u002For cow's milk allergy with specific IgE antibody titers that predict active (baked egg and\u002For baked milk) food allergy with cut-off titers as used at the consultation of allergy (KLL). Those children will become eligible however if their titers decrease while the study is still open.","ALL","12 Months","18 Years",{"count":77,"type":78},36,"ESTIMATED","INTERVENTIONAL",[81],"NA","The objective of the study is to study whether the introduction of heated food products (more specifically heated hen's egg and\u002For cow's milk) in children with EoE would be possible without re-occurrence of the eosinophilic inflammation, while the intake of less heated products might cause disease recidive. Moreover, we would like to study whether the gradual re-introduction of less heated products after the most heated form is tolerated, could lead to tolerance induction in EoE.",[84],"Eosinophilic Esophagitis","2026-05-04",{"date":87,"type":88},"2026-05-05","ACTUAL",{"date":90,"type":88},"2023-12-19",{"date":92,"type":78},"2028-12-31",{"name":5,"class":6},1]