[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100568660":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":25,"locations":34,"responsibleParty":51,"collaborators":20,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":20,"eligibilityCriteria":61,"healthyVolunteers":57,"sex":62,"minAge":63,"maxAge":64,"enrollmentInfo":65,"targetDuration":20,"studyType":68,"phases":69,"briefSummary":71,"conditions":72,"keywords":74,"overallStatus":36,"whyStopped":20,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},{"fullName":5,"class":6},"Children's Hospital Los Angeles","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Electrical Impedance Tomography positive end-expiratory pressure","EXPERIMENTAL","Patients will be monitored using Electrical Impedance Tomography and the positive end-expiratory pressure titration tool as their positive end-expiratory pressure is adjusted according to a step wise positive end-expiratory pressure titration protocol.",[13],"Device: Electrical Impedance Tomography positive end-expiratory pressure titration",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DEVICE","Electrical Impedance Tomography positive end-expiratory pressure titration","A PEEP titration will occur for the patient with the PEEP increased by 2 cm H2O every 2 minutes until a maximum PEEP of 20 or three steps (+ 6 cm H2O) above the set clinical PEEP. The PEEP will then be decreased by 2 cmH2O every 2 minutes until a minimum PEEP of 6 cmH2O or three steps (- 6 cm H2O) below their clinical PEEP.",[9],null,[22],{"name":23,"affiliation":5,"role":24},"Anoopindar Bhalla, MD","STUDY_DIRECTOR",[26,31],{"name":27,"role":28,"phone":29,"phoneExt":20,"email":30},"Hayden Leeds, MD","CONTACT","3233617939","hleeds@chla.usc.edu",{"name":23,"role":28,"phone":32,"phoneExt":20,"email":33},"323-361-7939","abhalla@chla.usc.edu",[35],{"facility":5,"status":36,"city":37,"state":38,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"RECRUITING","Los Angeles","California","90027","United States","US",{"type":43,"coordinates":44},"Point",[45,46],-118.24368,34.05223,{"lat":46,"lon":45},[49],{"name":50,"role":28,"phone":20,"phoneExt":20,"email":20},"Hayden Leeds",{"type":52,"investigatorFullName":53,"investigatorTitle":54,"investigatorAffiliation":5,"oldNameTitle":20,"oldOrganization":20},"PRINCIPAL_INVESTIGATOR","Anoopindar Bhalla","Medical Staff\u002FUSC Faculty","100568660","pediatric-positive-end-expiratory-pressure-peep-titration-using-electrical-impedence-tomography-eit-100568660",false,"NCT06684119","Pediatric Positive End Expiratory Pressure (PEEP) Titration Using Electrical Impedence Tomography (EIT)","Assessing Optimal Positive End-expiratory Pressure (PEEP) Using Electrical Impedance Tomography (EIT) During a PEEP Titration Protocol in Mechanically Ventilated Children with Pediatric Acute Respiratory Distress Syndrome (PARDS)","Inclusion Criteria:\n\n* Any person who is less than 18 years of age\n* is on invasive mechanical ventilation\n* is not spontaneously breathing\n* meets PARDS criteria\n\nExclusion Criteria:\n\n* Contraindication to the use of EIT\n* Hemodynamic instability\n* Contraindications to hypercapnia\n* patients with uncuffed endotracheal or tracheostomy tubes\n* diagnosis of pneumothorax or bronchopleural fistula\n* non-conventional ventilation\n* any patient on extra-corporeal membrane oxygenation (ECMO) support\n* less than 1 week post-operatively from cardiac surgery\n* the following cardiac diagnoses: Glenn or Fontan physiology, significant right to left shunt\n* Corrected Gestational Age \\\u003C 37 weeks\n* pregnancy","ALL","0 Years","18 Years",{"count":66,"type":67},60,"ESTIMATED","INTERVENTIONAL",[70],"NA","The goal of this clinical trial is to perform a PEEP titration protocol and use EIT to identify the optimal PEEP at which lung overdistention and collapse are most effectively balanced. The primary and secondary aims of the study are as follows:\n\nIdentify the difference between the optimal PEEP recommended by EIT metrics and the current guideline recommended approach to identifying optimal PEEP in PARDS. There will be a statistically significant difference in the recommended optimal PEEP identified using the EIT PEEP titration tool and that of the PEEP\u002FFiO2 grid recommendations.\n\nDetermine the difference in physiologic metrics between EIT optimal PEEP and the PEEP\u002FFiO2 recommended PEEP.\n\nParticipants will undergoing EIT monitoring while being subjected to PEEP titration protocol.",[73],"Pediatric Acute Respiratory Distress Syndrome",[75,76,77],"positive end-expiratory pressure","Electrical Impedance Tomography","respiratory distress","2025-02-05",{"date":80,"type":81},"2025-02-07","ACTUAL",{"date":83,"type":81},"2024-12-10",{"date":85,"type":67},"2027-07-01",{"name":5,"class":6},1]