[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100580402":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":30,"locations":39,"responsibleParty":81,"collaborators":25,"id":85,"slug":86,"hasResults":87,"nctId":88,"briefTitle":89,"officialTitle":90,"acronym":91,"eligibilityCriteria":92,"healthyVolunteers":87,"sex":93,"minAge":94,"maxAge":25,"enrollmentInfo":95,"targetDuration":25,"studyType":98,"phases":99,"briefSummary":101,"conditions":102,"keywords":107,"overallStatus":42,"whyStopped":25,"lastUpdateSubmitDate":115,"lastUpdatePostDateStruct":116,"startDateStruct":119,"completionDateStruct":121,"leadSponsor":123,"locationsCount":124},{"fullName":5,"class":6},"Muehlenkreiskliniken, MKK","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"PEEP","EXPERIMENTAL","PEEP Group (Intervention Group): Patients will receive mechanical ventilation with end-expiratory-pressure set at 5 mbar (PEEP).",[13],"Procedure: PEEP 5 mbar",{"label":15,"type":10,"description":16,"interventionNames":17},"ZEEP","ZEEP Group (Control Group): Patients will receive mechanical ventilation with end-expiratory-pressure set at 0 mbar (ZEEP).",[18],"Procedure: ZEEP 0 mbar",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"PROCEDURE","PEEP 5 mbar","Positiv-End-Expiratory Pressure",[9],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"ZEEP 0 mbar","Zero-End-Expiratory Pressure",[15],[31,36],{"name":32,"role":33,"phone":34,"phoneExt":25,"email":35},"Gerrit Jansen, PD Dr. med.","CONTACT","+49 571-790-54401","gerrit.jansen@muehlenkreiskliniken.de",{"name":37,"role":33,"phone":34,"phoneExt":25,"email":38},"Jochen Hinkelbein, Prof. Dr. med.","jochen.hinkelbein@muehlenkreiskliniken.de",[40,62,74],{"facility":41,"status":42,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"Emergency Medical Services","RECRUITING","Gütersloh","North Rhine-Westphalia","33324","Germany","DE",{"type":49,"coordinates":50},"Point",[51,52],8.37853,51.90693,{"lat":52,"lon":51},[55,59],{"name":56,"role":33,"phone":57,"phoneExt":25,"email":58},"Julia Johanna Grannemann, MD, MSc","+491706765460","j.grannemann@kreis-guetersloh.de",{"name":60,"role":33,"phone":25,"phoneExt":25,"email":61},"Bernd Strickmann, MD","b.strickmann@kreis-guetersloh.de",{"facility":63,"status":42,"city":64,"state":44,"zip":65,"country":46,"countryCode":47,"cosmosGeoPoint":66,"geoPoint":70,"contacts":71},"JWK Minden","Minden","32429",{"type":49,"coordinates":67},[68,69],8.91455,52.28953,{"lat":69,"lon":68},[72],{"name":73,"role":33,"phone":25,"phoneExt":25,"email":25},"Jochen Hinkelbein, MD",{"facility":41,"status":42,"city":75,"state":25,"zip":25,"country":46,"countryCode":47,"cosmosGeoPoint":76,"geoPoint":80,"contacts":25},"Osnabrück",{"type":49,"coordinates":77},[78,79],8.0498,52.27264,{"lat":79,"lon":78},{"type":82,"investigatorFullName":83,"investigatorTitle":84,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Gerrit Jansen","Principal Investigator","100580402","peep-vs-zeep-in-out-of-hospital-cardiac-arrest-100580402",false,"NCT06836830","PEEP vs. ZEEP in Out-of-Hospital-Cardiac-Arrest","Peri-Arrest Ventilation With Positive End-Expiratory-Pressure vs. Zero End-Expiratory-Pressure in Out-of-Hospital-Cardiac-Arrest","PerAVent","Inclusion Criteria:\n\n* Adults \\>= 18 years\n* non-traumatic OHCA\n* mechanical ventilation via airway device\n\nExclusion Criteria:\n\n* Patients \\\u003C 18 years,\n* traumatic cause of OHCA,\n* no cardiac arrest, withholding of resuscitation (e.g. Do-Not-Resuscitate orders)","ALL","18 Years",{"count":96,"type":97},600,"ESTIMATED","INTERVENTIONAL",[100],"NA","Out-of-hospital cardiac arrest (OHCA) remains a major cause of mortality, with low survival probabilities to hospital discharge. Despite the frequent use of airway management and mechanical ventilation during resuscitation, there is limited evidence regarding the optimal ventilation strategy to improve oxygen delivery and patient outcomes. The present study aims to investigate the effects of positive-end-expiratory-pressure (PEEP) set at 5 mbar compared to zero-end-expiratory-pressure (ZEEP) on the return of spontaneous-circulation (ROSC) in adult patients with OHCA.",[103,104,105,106],"Ventilation Therapy","PEEP, Occult","CPR","Cardiac Arrest (CA)",[108,109,110,111,112,113,114,105],"Cardiac Arrest","Positive End-Expiratory Pressure","Zero End-Expiratory Pressure","Ventilation","Randomized Controlled Trial","Emergency Medicine","Resuscitation","2025-08-05",{"date":117,"type":118},"2025-08-06","ACTUAL",{"date":120,"type":118},"2025-06-01",{"date":122,"type":97},"2026-10-31",{"name":5,"class":6},3]