[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100618154":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":40,"centralContacts":44,"locations":52,"responsibleParty":68,"collaborators":31,"id":70,"slug":71,"hasResults":72,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":31,"eligibilityCriteria":76,"healthyVolunteers":72,"sex":77,"minAge":78,"maxAge":79,"enrollmentInfo":80,"targetDuration":31,"studyType":83,"phases":84,"briefSummary":86,"conditions":87,"keywords":31,"overallStatus":54,"whyStopped":31,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"Poznan University of Medical Sciences","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"PENG Block With Intravenous Dexamethasone","ACTIVE_COMPARATOR","Participants will receive a Pericapsular Nerve Group (PENG) block using 20 mL of 0.2% ropivacaine. As part of the study medications, they will receive 4 mg of dexamethasone intravenously and perineural normal saline as placebo, so that the number and volume of injections are identical across all groups.",[13],"Drug: Dexamethasone (intravenous)",{"label":15,"type":10,"description":16,"interventionNames":17},"PENG Block With Perineural Dexmedetomidine and Intravenous Dexamethasone","Participants will receive a PENG block using 20 mL of 0.2% ropivacaine combined with 25 µg of dexmedetomidine administered perineurally. In addition, they will receive 4 mg of dexamethasone intravenously. Perineural normal saline may be added to match the total volume of perineural injectate across groups.",[18],"Drug: Dexamethasone (intravenous) with Dexmedetomidine (perineural)",{"label":20,"type":21,"description":22,"interventionNames":23},"PENG Block With Perineural Dexmedetomidine and Perineural Dexamethasone","EXPERIMENTAL","Participants will receive a PENG block using 20 mL of 0.2% ropivacaine combined with 25 µg of dexmedetomidine and 4 mg of dexamethasone administered perineurally. Intravenously they will receive normal saline as placebo instead of dexamethasone in order to maintain blinding.",[24],"Drug: Dexamethasone (perineural) with Dexmedetomidine (perineural)",[26,32,36],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"DRUG","Dexamethasone (intravenous)","Perineural: 20 mL 0.2% ropivacaine + perineural placebo (normal saline) Intravenous: 4 mg dexamethasone + matching volume of saline if needed",[9],null,{"type":27,"name":33,"description":34,"armGroupLabels":35,"otherNames":31},"Dexamethasone (intravenous) with Dexmedetomidine (perineural)","Perineural: 20 mL 0.2% ropivacaine + 25 µg dexmedetomidine (± saline to equalize volume) Intravenous: 4 mg dexamethasone",[15],{"type":27,"name":37,"description":38,"armGroupLabels":39,"otherNames":31},"Dexamethasone (perineural) with Dexmedetomidine (perineural)","Perineural: 20 mL 0.2% ropivacaine + 25 µg dexmedetomidine + 4 mg dexamethasone Intravenous: placebo (0.9% normal saline)",[20],[41],{"name":42,"affiliation":5,"role":43},"Malgorzata Reysner","STUDY_CHAIR",[45,50],{"name":46,"role":47,"phone":48,"phoneExt":31,"email":49},"Malgorzata Reysner, MD PhD","CONTACT","+48 61 873 83 03","mreysner@ump.edu.pl",{"name":51,"role":47,"phone":48,"phoneExt":31,"email":49},"Mslgorzata Reysner, MD PhD",[53],{"facility":5,"status":54,"city":55,"state":31,"zip":56,"country":57,"countryCode":58,"cosmosGeoPoint":59,"geoPoint":64,"contacts":65},"RECRUITING","Poznan","62-701","Poland","PL",{"type":60,"coordinates":61},"Point",[62,63],16.92993,52.40692,{"lat":63,"lon":62},[66],{"name":67,"role":47,"phone":48,"phoneExt":31,"email":49},"Malgorzata Reysner, M.D. Ph.D.",{"type":69,"investigatorFullName":31,"investigatorTitle":31,"investigatorAffiliation":31,"oldNameTitle":31,"oldOrganization":31},"SPONSOR","100618154","peng-block-variants-with-dexamethasone-and-dexmedetomidine-in-older-adults-100618154",false,"NCT07327931","PENG Block Variants With Dexamethasone and Dexmedetomidine in Older Adults","Comparison of Three Variants of PENG Block Using 20 mL of 0.2% Ropivacaine With Different Combinations of Dexamethasone and Perineural Dexmedetomidine in Patients Aged 65 Years and Older Undergoing Hip Surgery: A Randomized Controlled Trial.","Inclusion Criteria:\n\n* Age 65 years or older\n* Scheduled for elective or emergency hip surgery (e.g., hip fracture fixation or hip arthroplasty)\n* ASA physical status I-III\n* Ability to communicate pain intensity using the NRS scale\n* Written informed consent obtained from the patient or legal representative\n* Planned use of PENG block as part of multimodal perioperative analgesia\n\nExclusion Criteria:\n\n* Patient refusal or inability to provide informed consent\n* Allergy, intolerance, or contraindication to any study medication: ropivacaine, dexamethasone, dexmedetomidine\n* Pre-existing neurological deficit or neuropathy of the affected limb\n* Coagulopathy (INR \\>1.5, platelets \\\u003C100,000\u002FµL) or current therapeutic anticoagulation that contraindicates regional anesthesia\n* Infection at or near the injection site\n* Severe hepatic or renal impairment\n* History of chronic opioid use (daily opioids \\>30 days before surgery)\n* Cognitive impairment or delirium precluding reliable pain assessment\n* BMI \\> 40 kg\u002Fm² (if you want to exclude for technical difficulty)\n* Patients receiving another regional nerve block for hip surgery\n* Pregnancy or breastfeeding\n* Participation in another interventional clinical trial within 30 days","ALL","65 Years","100 Years",{"count":81,"type":82},120,"ESTIMATED","INTERVENTIONAL",[85],"NA","This study will compare three different versions of the Pericapsular Nerve Group (PENG) block in adults aged 65 years and older who are undergoing surgery for hip conditions. The PENG block is a regional anesthesia technique that can reduce pain after surgery and decrease the need for strong opioid pain medications.\n\nAll patients in the study will receive the PENG block with 20 mL of 0.2% ropivacaine, but they will be divided into three groups based on the additional medications used:\n\nGroup 1: PENG block with ropivacaine plus 4 mg of dexamethasone given intravenously.\n\nGroup 2: PENG block with ropivacaine plus 25 micrograms of dexmedetomidine given near the nerves and 4 mg of dexamethasone given intravenously.\n\nGroup 3: PENG block with ropivacaine plus 25 micrograms of dexmedetomidine and 4 mg of dexamethasone given near the nerves.\n\nBoth dexmedetomidine and dexamethasone are medications that may improve the strength and duration of nerve blocks.\n\nThe main goal of this study is to determine which combination provides the best pain control after hip surgery, reduces the need for opioid medications, and improves patient comfort and recovery. We also aim to evaluate the safety and side-effects of each technique.\n\nWe hypothesize that adding both dexmedetomidine and dexamethasone near the nerves will provide the longest and most effective pain relief when compared to intravenous administration alone.\n\nThis trial may help identify the most effective PENG block formula for older adults undergoing hip surgery and could improve pain management, decrease complications related to opioids, and support faster recovery.",[88,89],"Hip Osteoarthritis","Hip Pain Chronic","2026-05-20",{"date":92,"type":93},"2026-05-22","ACTUAL",{"date":95,"type":93},"2026-02-13",{"date":97,"type":82},"2027-01-31",{"name":5,"class":6},1]