[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100593241":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":10,"centralContacts":10,"locations":10,"responsibleParty":20,"collaborators":10,"id":22,"slug":23,"hasResults":24,"nctId":25,"briefTitle":26,"officialTitle":27,"acronym":28,"eligibilityCriteria":29,"healthyVolunteers":24,"sex":30,"minAge":31,"maxAge":10,"enrollmentInfo":32,"targetDuration":10,"studyType":35,"phases":10,"briefSummary":36,"conditions":37,"keywords":10,"overallStatus":39,"whyStopped":10,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":10},{"fullName":5,"class":6},"Sir Mortimer B. Davis - Jewish General Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Patients undergoing an otolaryngology in-office procedure using methoxyflurane",null,"All adult patients undergoing any of the following procedures with inhaled methoxyflurane as an adjunct to topical or local anesthesia:\n\n* Skin lesion excision or reconstruction\n* Fine or core needle aspiration biopsy\n* Mucosal biopsy\n* Laryngeal injection or biopsy\n* Myringotomy with or without tympanostomy tube insertion\n* Inferior turbinate reduction\n* Septal button insertion",[13],"Drug: Methoxyflurane anesthesia",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":10},"DRUG","Methoxyflurane anesthesia","A single Penthrox (3mL) self-inhaler will be administered 5-minutes prior to the onset of the procedure, before local anesthesia. Patients will undergo the procedure, have post-procedural vital signs, and remain in clinic for observation for 30 minutes post-procedure per our usual post-procedure monitoring.",[9],{"type":21,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100593241","penthrox-in-otolaryngology-100593241",false,"NCT07003880","Penthrox in Otolaryngology","Inhaled Methoxyflurane for In-Office Procedures in Otolaryngology","PenthroxOTL","Inclusion Criteria:\n\n* All adult patients undergoing any of the following procedures with inhaled methoxyflurane as an adjunct to topical or local anesthesia:\n\n  * Skin lesion excision or reconstruction\n  * Fine or core needle aspiration biopsy\n  * Mucosal biopsy\n  * Laryngeal injection or biopsy\n  * Myringotomy with or without tympanostomy tube insertion\n  * Inferior turbinate reduction\n  * Septal button insertion\n\nExclusion Criteria:\n\n* Patient unable to complete the post-procedure questionnaire (either due to time constraints, neurocognitive impairment, etc.)\n* Presence of any contraindications to inhaled methoxyfluorane per product monograph:\n\n  * Patients less than 18 years of age\n  * Pregnancy, intended pregnancy, or current breast-feeding\n  * Inadequate patient understanding or lack of cooperation\n  * Decreased level of consciousness or head injury\n  * History of clinically significant renal impairment, e.g., reduced renal output\n  * History of liver dysfunction following previous exposure to halogenated anesthetics\n  * Current use of tetracycline antibiotics\n  * Personal or genetic history of malignant hyperthermia\n  * Muscular dystrophy","ALL","18 Years",{"count":33,"type":34},50,"ESTIMATED","OBSERVATIONAL","Our objective is to explore the use of methoxyflurane anesthesia as an adjunct analgesic to local anesthesia during in-office otolaryngology procedures in a prospective pilot study. The main outcome of this study will be patient satisfaction with the medication and analgesia. Secondary outcomes will include level of sedation and analgesia, patient-reported post-procedural pain levels, and any reported adverse events.",[38],"All Adult Patients Undergoing an Otolaryngology Procedure With Inhaled Methoxyflurane as an Adjunct to Topical or Local Anesthesia","NOT_YET_RECRUITING","2025-05-26",{"date":42,"type":43},"2025-06-04","ACTUAL",{"date":45,"type":34},"2025-06-01",{"date":47,"type":34},"2027-06-01",{"name":5,"class":6}]