[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100557114":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":11,"centralContacts":11,"locations":28,"responsibleParty":52,"collaborators":11,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":58,"acronym":11,"eligibilityCriteria":59,"healthyVolunteers":60,"sex":61,"minAge":62,"maxAge":63,"enrollmentInfo":64,"targetDuration":11,"studyType":67,"phases":68,"briefSummary":70,"conditions":71,"keywords":81,"overallStatus":87,"whyStopped":11,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"Loma Linda University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Standard multi-modal pain regimen alone","PLACEBO_COMPARATOR",null,[13],"Other: Multi-modal pain regimen",{"label":15,"type":16,"description":11,"interventionNames":17},"Standard multi-modal pain regimen with percutaneous cryoablation","EXPERIMENTAL",[18,13],"Procedure: Percutaneous Cryoablation of Intercostal Nerves",[20,24],{"type":21,"name":22,"description":22,"armGroupLabels":23,"otherNames":11},"PROCEDURE","Percutaneous Cryoablation of Intercostal Nerves",[15],{"type":6,"name":25,"description":26,"armGroupLabels":27,"otherNames":11},"Multi-modal pain regimen","Standard rib fracture protocol including cyclooxygenase inhibitors, anti-neuropathic, muscle relaxers, short term anesthesia interventions (percutaneous block, epidural)",[9,15],[29],{"facility":30,"status":11,"city":31,"state":32,"zip":33,"country":34,"countryCode":35,"cosmosGeoPoint":36,"geoPoint":41,"contacts":42},"Loma Linda University Health","Loma Linda","California","92354","United States","US",{"type":37,"coordinates":38},"Point",[39,40],-117.26115,34.04835,{"lat":40,"lon":39},[43,48],{"name":44,"role":45,"phone":46,"phoneExt":11,"email":47},"Martin G Rosenthal, MD","CONTACT","909-558-4286","mrosenthal@llu.edu",{"name":49,"role":45,"phone":50,"phoneExt":11,"email":51},"Matthew E Reeves, MD","909-558-4289","mareeves@llu.edu",{"type":53,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100557114","percutaneous-cryoablation-of-intercostal-nerves-for-the-treatment-of-rib-fractures-100557114",false,"NCT06533904","Percutaneous Cryoablation of Intercostal Nerves for the Treatment of Rib Fractures","Inclusion Criteria:\n\n* \\> 18 years old\n* \\> 2 rib fractures\n* Verbal Pain score \\> 5\n* Incentive Spirometry \\\u003C 60% of predicted\n\nExclusion Criteria:\n\n* Isolated Fractures of Ribs 1-3 and\u002For 10-12\n* Posterior Rib Fracture \\\u003C 4 cm from costovertebral joint\n* Sternal, Clavicle, Scapula Fracture\n* Thoracic Spinal Fracture of any type\n* Open Abdominothoracic Surgery\n* Unstable Spine\n* Extensive Subcutaneous Emphysema\n* BMI \\> 35\n* Plan for Rib Plating\n* Chronic Opioid Use\n* Prior to study enrollment: Intubated, Traumatic Brain Injury, Dementia, Cognitive Impairment, Encephalopathy\n* Coagulopathy, Shock at time of ablation\n* Inability to participate in activities of daily living prior to injury\n* Home O2 use prior to trauma\n* Inhalation Injury\n* Rib Fractures due to cardiopulmonary resuscitation\n* Life Expectancy \\\u003C 6 months\n* \\> 48 hours from injury\n* Pregnant, Incarcerated",true,"ALL","18 Years","80 Years",{"count":65,"type":66},30,"ESTIMATED","INTERVENTIONAL",[69],"NA","The goal of this double blinded randomized control trial is to learn if percutaneous cryoablation of traumatic rib fractures improves outcomes. The main questions it aims to answer are:\n\nDoes percutaneous cryoablation improve short and long term pain scores? Does percutaneous cryoablation improve short and long term respiratory mechanics? Does percutaneous cryoablation improve long term quality of life? Does percutaneous cryoablation decrease delirium?\n\nResearchers will compare cryoablation to standard multimodal pain therapy to see if this impacts respiratory recovery.\n\nParticipants will undergo randomization, percutaneous cryoablative procedure, and participate in tests at pre-determined intervals to evaluate their pulmonary recovery.",[72,73,74,75,76,77,78,79,80],"Trauma","Rib Fractures","Chest Wall Disorder","Respiratory Insufficiency","Pain, Chest","Rib Trauma","Rib Fracture Multiple","Respiratory Failure","Respiratory Distress Syndrome",[72,79,82,75,73,83,84,85,86],"Respiratory Distress","Chest Wall Trauma","Percutaneous Cryoablation","Multimodal Pain Therapy","Multimodal Pain Regimen","NOT_YET_RECRUITING","2026-02-05",{"date":90,"type":91},"2026-02-09","ACTUAL",{"date":93,"type":66},"2026-09",{"date":95,"type":66},"2028-07",{"name":5,"class":6},1]