[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100461957":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":24,"locations":30,"responsibleParty":56,"collaborators":59,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":73,"eligibilityCriteria":74,"healthyVolunteers":69,"sex":75,"minAge":76,"maxAge":77,"enrollmentInfo":78,"targetDuration":81,"studyType":82,"phases":10,"briefSummary":83,"conditions":84,"keywords":86,"overallStatus":33,"whyStopped":10,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"Endeavor Health","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Men 40-69 years old",null,"Men with moderately-elevated PSA (2.5-10 ng\u002FmL) undergoing prostate biopsy for detecting prostate cancer at NorthShore University HealthSystem, Northwestern University, or Johns Hopkins Hospital. The trial will not alter any clinical practice for diagnostic biopsy that includes state-of-the-art procedures (transperineal fusion biopsy, multiparametric MRI, and novel biomarkers).",[13],"Genetic: Genetic Assessment",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":10},"GENETIC","Genetic Assessment","The trial is to observe whether inherited risk, including rare pathogenic mutations (RPMs) in several major genes and SNPs-based genetic risk scores (GRS), is correlated with prostate cancer detection rate from diagnostic prostate biopsy.",[9],[21],{"name":22,"affiliation":5,"role":23},"Jianfeng Xu, MD, Dr.PH","PRINCIPAL_INVESTIGATOR",[25],{"name":26,"role":27,"phone":28,"phoneExt":10,"email":29},"Annie Ashworth","CONTACT","2243647502","aashworth@northshore.org",[31],{"facility":32,"status":33,"city":34,"state":35,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"NorthShore University HealthSystem","RECRUITING","Evanston","Illinois","60626","United States","US",{"type":40,"coordinates":41},"Point",[42,43],-87.69006,42.04114,{"lat":43,"lon":42},[46,50,54],{"name":47,"role":27,"phone":48,"phoneExt":10,"email":49},"Pooja Talaty","847-503-4280","ptalaty@northshore.org",{"name":51,"role":27,"phone":52,"phoneExt":10,"email":53},"Malgorzata Antoniak","847-570-2112","mantoniak@northshore.org",{"name":55,"role":23,"phone":10,"phoneExt":10,"email":10},"Jianfeng Xu, MD, DrPH",{"type":23,"investigatorFullName":57,"investigatorTitle":58,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Jianfeng Xu","Director of Program for Personalized Cancer Care",[60,62,64],{"name":61,"class":6},"Northwestern University",{"name":63,"class":6},"Johns Hopkins University",{"name":65,"class":66},"GoPath Diagnostics","UNKNOWN","100461957","performance-of-inherited-risk-assessment-for-predicting-prostate-cancer-from-prostate-biopsy-100461957",false,"NCT05295407","Performance of Inherited Risk Assessment for Predicting Prostate Cancer From Prostate Biopsy","Observational and Prospective Study on the Performance of Inherited Risk Assessment for Predicting Prostate Cancer From Prostate Biopsy (GenBx)","GenBx","Inclusion Criteria:\n\n* Consecutive patients undergoing prostate biopsy for detection of prostate cancer\n* Aged 40 to 69 years\n* Four ethnicity groups (Caucasian, African Americans, East Asians, Latinos)\n* PSA between 2.5-10 ng\u002FmL\n\nExclusion Criteria:\n\n* Previous diagnosis of prostate cancer.\n* Ethnicity outside the inclusion criterion (including mixed ethnicity).\n* Any prior PSA test result outside the range of inclusion criterion.","MALE","40 Years","69 Years",{"count":79,"type":80},1000,"ESTIMATED","2 Months","OBSERVATIONAL","Condition: Prostate cancer Intervention: Biopsy and inherited risk assessment",[85],"Prostate Cancer",[87,88,89,90],"Prostate biopsy","prostate cancer","inherited risk assessment","PSA","2026-02-24",{"date":93,"type":94},"2026-02-27","ACTUAL",{"date":96,"type":94},"2021-12-13",{"date":98,"type":80},"2027-12-13",{"name":5,"class":6},1]