[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100631960":3},{"organization":4,"armGroups":7,"interventions":8,"overallOfficials":7,"centralContacts":24,"locations":30,"responsibleParty":50,"collaborators":7,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":60,"eligibilityCriteria":61,"healthyVolunteers":56,"sex":62,"minAge":63,"maxAge":7,"enrollmentInfo":64,"targetDuration":7,"studyType":67,"phases":7,"briefSummary":68,"conditions":69,"keywords":71,"overallStatus":32,"whyStopped":7,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},{"fullName":5,"class":6},"University of Pisa","OTHER",null,[9,15,19],{"type":10,"name":11,"description":12,"armGroupLabels":7,"otherNames":13},"PROCEDURE","Periodontal non surgical treatment","Non surgical periodontal therapy performed with ultrasonics and manual instruments. In patients affected by stages III-IV periodontitis, the adjunctive usage of wound healing enhancers will be applied in sites with PPD \\>5 mm.",[14],"Scaling and root planing",{"type":16,"name":17,"description":18,"armGroupLabels":7,"otherNames":7},"BEHAVIORAL","Oral Hygiene Instructions","Patients will be motivated and instructed to improve their daily home dental plaque control through the usage of interdental devices and electric toothbrush.",{"type":10,"name":20,"description":21,"armGroupLabels":7,"otherNames":22},"Surgical Periodontal Treatment","In some selected patients, whose periodontal defects will not heal despite consecutive non surgical interventions, periodontal surgical treatment, with or without regenerative devices, will be implemented.",[23],"periodontal surgery",[25],{"name":26,"role":27,"phone":28,"phoneExt":7,"email":29},"Filippo Graziani, Prof.","CONTACT","+393384014984","filippo.graziani@unipi.it",[31],{"facility":5,"status":32,"city":33,"state":34,"zip":35,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"RECRUITING","Pisa","None Selected","56126","Italy","IT",{"type":39,"coordinates":40},"Point",[41,42],10.4036,43.70853,{"lat":42,"lon":41},[45,48],{"name":46,"role":27,"phone":7,"phoneExt":7,"email":47},"Filippo Graziani","filippograziani@med.unipi.it",{"name":7,"role":27,"phone":7,"phoneExt":7,"email":49},"rossana.izzetti@unipi.it",{"type":51,"investigatorFullName":52,"investigatorTitle":53,"investigatorAffiliation":5,"oldNameTitle":7,"oldOrganization":7},"PRINCIPAL_INVESTIGATOR","Filippo Graziani, DDS MClinDent PhD","Full Professor, DMD, MClinDent, PhD","100631960","performance-of-the-treatment-of-periodontitis-according-to-the-bioperio-protocol-100631960",false,"NCT07507474","Performance of the Treatment of Periodontitis According to the Bioperio® Protocol","Performance of the Treatment of Periodontitis According to the Bioperio® Protocol: a Prospective Cohort Study","BIOPERIO","Inclusion Criteria:\n\n* Confirmed diagnosis of periodontitis (proximal attachment loss in ≥2 non-adjacent teeth)\n* No previous treatment for periodontitis\n* Systemically healthy or with well-controlled chronic medical conditions\n* Willingness to participate in the study and comply with the follow-up schedule\n\nExclusion Criteria:\n\n* Pregnancy or breastfeeding\n* Patients previously treated for periodontitis\n* Poorly controlled systemic conditions\n* Refusal to participate\n* Patients who did not complete the proposed treatment plan","ALL","18 Years",{"count":65,"type":66},5000,"ESTIMATED","OBSERVATIONAL","This multicenter, prospective, single-arm observational study evaluated the clinical performance of the Bioperio® protocol, a standardized, patient-centered framework for managing periodontitis. The protocol combined professional supra-gingival scaling, oral hygiene instruction and motivation, full-mouth subgingival instrumentation, and-in Stage III\u002FIV cases-adjunctive enamel matrix derivative application in deep pockets.",[70],"Periodontitis",[72,73,74,75,76,77],"Enamel matrix proteins","dental scaling","root planing","oral hygiene","non-surgical periodontal therapy","periodontitis","2026-04-27",{"date":80,"type":81},"2026-05-01","ACTUAL",{"date":83,"type":81},"2023-12-05",{"date":85,"type":66},"2030-12-05",{"name":5,"class":6},1]