[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100466724":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":32,"centralContacts":36,"locations":44,"responsibleParty":66,"collaborators":10,"id":69,"slug":70,"hasResults":71,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":10,"eligibilityCriteria":75,"healthyVolunteers":76,"sex":77,"minAge":78,"maxAge":79,"enrollmentInfo":80,"targetDuration":10,"studyType":83,"phases":10,"briefSummary":84,"conditions":85,"keywords":89,"overallStatus":47,"whyStopped":10,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":102},{"fullName":5,"class":6},"The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"autonomous cortisol secretion",null,"Patients admitted to the hospital with adrenal incidentalomas are evaluated for adrenal function, and then ACS patients are diagnosed based on the serum cortisol ≥ 50 nmol\u002FL following the 1 mg dexamethasone suppression test and without any other signs or symptoms of cortisol excess.Patients with ACS will undergo a physical exam, cognitive function test as well as structural and functional brain MRI at baseline and 12 months after their surgery or conservative treatment.",[13,14],"Behavioral: Cognitive function assessment; functional magnetic resonance imaging","Procedure: laparoscopic adrenal surgery",{"label":16,"type":10,"description":17,"interventionNames":18},"non-functioning adrenal adenomas","Patients admitted to the hospital with adrenal incidentalomas are evaluated for adrenal function, and then non-functioning adrenal adenomas patients are diagnosed based on the serum cortisol \\\u003C 50 nmol\u002FL following the 1 mg dexamethasone suppression test .Patients with non-functioning adrenal adenomas will undergo a physical exam, cognitive function test as well as structural and functional brain MRI at baseline.",[13],[20,27],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"BEHAVIORAL","Cognitive function assessment; functional magnetic resonance imaging","cognitive function measurement",[9,16],[26],"fMRI",{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":10},"PROCEDURE","laparoscopic adrenal surgery","Only a subgroup of the autonomous cortisol secretion patients will have the laparoscopic adrenal surgery",[9],[33],{"name":34,"affiliation":5,"role":35},"Dalong Zhu, MD,PhD","PRINCIPAL_INVESTIGATOR",[37,41],{"name":34,"role":38,"phone":39,"phoneExt":10,"email":40},"CONTACT","86-25-83-105302","zhudalong@nju.edu.cn",{"name":42,"role":38,"phone":39,"phoneExt":10,"email":43},"PIng Li, MD,PhD","li78321@yeah.net",[45],{"facility":46,"status":47,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"Department of Endocrinology, Drum Tower Hospital affiliated to Nanjing University Medical School","RECRUITING","Nanjing","Jiangsu","210008","China","CN",{"type":54,"coordinates":55},"Point",[56,57],118.77778,32.06167,{"lat":57,"lon":56},[60,61,63,64],{"name":34,"role":38,"phone":39,"phoneExt":10,"email":40},{"name":62,"role":38,"phone":39,"phoneExt":10,"email":43},"Ping Li, MD,PhD",{"name":34,"role":35,"phone":10,"phoneExt":10,"email":10},{"name":62,"role":65,"phone":10,"phoneExt":10,"email":10},"SUB_INVESTIGATOR",{"type":35,"investigatorFullName":67,"investigatorTitle":68,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Dalong Zhu","Chief Physician","100466724","performances-on-cognitive-functions-and-brain-function-and-follow-up-after-different-treatments-in-patients-with-autonomous-cortisol-secretion-a-single-center-prospective-observational-study-100466724",false,"NCT05357456","Performances on Cognitive Functions and Brain Function and Follow-up After Different Treatments in Patients With Autonomous Cortisol Secretion: a Single-center, Prospective, Observational Study","A Single Center, Prospective, Observational Study to Explore and Evaluate the Differences of Cognitive Function and Brain Function Between Non-functioning Adrenal Adenomas and Autonomous Cortisol Secretion Patients, and the Different Treatments Methods on Cognitive Function and Brain Function in Patients With Autonomous Cortisol Secretion","Inclusion Criteria:\n\n* age 20-65 years;\n* ≥ 6 years of education；\n* right-handed;\n* complete entire cognitive function tests;\n* adrenal lesions ≥ 1 cm in diameter;\n* patients with non-functioning adrenal adenomas;\n* patients with autonomous cortisol secretion.\n\nExclusion Criteria:\n\n* \\\u003C 6 years of education;\n* age \\\u003C 20 years or \\> 65 years;\n* maximum diameter of AI \\\u003C1cm;\n* active malignancies;\n* with a history of thyroid disease;\n* with a history of acute infection in the last month;\n* central nervous system diseases, including brain trauma, intracranial hemorrhage, acute cerebral infarction, etc;\n* contraindications of MRI examination: such as implantation of metal prosthesis in vivo, claustrophobia, etc;\n* adrenal tuberculosis;\n* suspected or diagnosed adrenocortical carcinoma;\n* unable to complete entire cognitive function tests;\n* current use of steroids or any drugs known to alter steroid synthesis or metabolism in the previous 3 months;\n* clinical Cushing syndrome;\n* Cushing disease;\n* primary hyperaldosteronism;\n* pheochromocytoma;\n* severe impairment of heart, liver, kidney and other organs;\n* pregnant and lactating women",true,"ALL","20 Years","65 Years",{"count":81,"type":82},62,"ESTIMATED","OBSERVATIONAL","This is a single center, prospective, observational study to explore and evaluate the differences on cognitive function and brain function by functional-MRI in autonomous cortisol secretion patients, and the different treatments methods on the cognitive function and brain function in patients with autonomous cortisol secretion",[86,87,88],"Autonomous Cortisol Secretion","Adrenal Incidentaloma","Non-functioning Adrenal Adenomas",[90,91,92],"cognitive function","functional MRI","treatment","2022-04-27",{"date":95,"type":96},"2022-05-02","ACTUAL",{"date":98,"type":96},"2021-10-01",{"date":100,"type":82},"2026-10-01",{"name":5,"class":6},1]