[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100643946":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":35,"locations":41,"responsibleParty":57,"collaborators":26,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":26,"eligibilityCriteria":67,"healthyVolunteers":63,"sex":68,"minAge":69,"maxAge":70,"enrollmentInfo":71,"targetDuration":26,"studyType":74,"phases":75,"briefSummary":77,"conditions":78,"keywords":80,"overallStatus":87,"whyStopped":26,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"Beirut Arab University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Connective Tissue Graft","ACTIVE_COMPARATOR","Participants will receive peri-implant soft tissue augmentation using a subepithelial connective tissue graft harvested from the palate during implant second-stage surgery. The graft will be placed at the buccal aspect of the implant site to increase peri-implant mucosal thickness and improve soft tissue phenotype stability.",[13],"Procedure: Connective Tissue Graft (CTG)",{"label":15,"type":16,"description":17,"interventionNames":18},"Microneedling + Injectable Platelet-Rich Fibrin (MN+i-PRF)","EXPERIMENTAL","Participants will receive peri-implant soft tissue augmentation using microneedling with a sterile automated microneedling device followed by injection of autologous injectable platelet-rich fibrin (i-PRF). The procedure will be performed during implant second-stage surgery and repeated at 2 and 4 weeks postoperatively.",[19],"Procedure: Microneedling with Injectable Platelet-Rich Fibrin (MN+i-PRF)",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","Connective Tissue Graft (CTG)","Peri-implant soft tissue augmentation performed using a subepithelial connective tissue graft harvested from the palate during implant second-stage surgery. The graft is placed at the buccal aspect of the implant site to increase mucosal thickness and improve peri-implant soft tissue phenotype.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Microneedling with Injectable Platelet-Rich Fibrin (MN+i-PRF)","Peri-implant soft tissue augmentation performed using automated microneedling followed by injection of autologous injectable platelet-rich fibrin (i-PRF) during implant second-stage surgery. The intervention is repeated at 2 and 4 weeks postoperatively to enhance peri-implant soft tissue thickness and quality.",[15],[32],{"name":33,"affiliation":5,"role":34},"Nayer Aboelsaad, PHD","STUDY_CHAIR",[36],{"name":37,"role":38,"phone":39,"phoneExt":26,"email":40},"Ranim Ahmad, Msc Oral & Dental Surgery","CONTACT","+961 79129351","raneem-ahmad1998@hotmail.com",[42],{"facility":5,"status":26,"city":43,"state":26,"zip":26,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"Beirut","Lebanon","LB",{"type":47,"coordinates":48},"Point",[49,50],35.50157,33.89332,{"lat":50,"lon":49},[53],{"name":54,"role":38,"phone":55,"phoneExt":26,"email":56},"Nayer Aboelsaad, Phd","+96179109899","naier74@gmail.com",{"type":58,"investigatorFullName":59,"investigatorTitle":60,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Nayer Aboelsaad","Professor and chairperson of Periodontology Department","100643946","peri-implant-soft-tissue-augmentation-using-microneedling-with-i-prf-vs-connective-tissue-graft-100643946",false,"NCT07667855","Peri-implant Soft Tissue Augmentation Using Microneedling With i-PRF vs. Connective Tissue Graft","Peri-implant Soft Tissue Augmentation Using Microneedling With i-PRF vs. Connective Tissue Graft: A Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* Systemically healthy adults (Between 18 and 65) with one or more dental implants requiring second-stage surgery in the esthetic zone (Anteriors and Premolars).\n* Thin soft tissue phenotype: mucosal thickness or KTW \\\u003C2 mm buccally.\n* Stable osseointegrated implant, adequate restorative space, and healthy adjacent teeth.\n* Good oral hygiene (PI ≤10%), with peri-implant maintenance.\n* Signed consent + willingness for 1-year follow-up.\n\nExclusion Criteria:\n\n* Heavy smokers (≥10 cig\u002Fday); light smokers only if reduced.\n* Systemic\u002Fhealing issues: uncontrolled diabetes, immunocompromise, bleeding disorders, anticoagulants, steroids.\n* Pregnancy or breastfeeding.\n* Active infection (periodontal or peri-implant).\n* No residual keratinized mucosa on buccal side.\n* Previous graft\u002Faugmentation at the site or recent surgery (\\\u003C6 months).\n* Allergies to anesthetics\u002Fmaterials.\n* Non-compliance with instructions or follow-up.","ALL","18 Years","65 Years",{"count":72,"type":73},24,"ESTIMATED","INTERVENTIONAL",[76],"NA","This randomized controlled clinical trial aims to evaluate a minimally invasive technique for peri-implant soft tissue augmentation using microneedling combined with injectable platelet-rich fibrin (i-PRF) compared with the current gold-standard connective tissue graft (CTG). Patients with thin peri-implant soft tissue requiring implant second-stage surgery in the esthetic zone will be randomly assigned to receive either CTG harvested from the palate or a series of microneedling and i-PRF treatments. Clinical outcomes including mucosal thickness, keratinized tissue width, peri-implant health parameters, volumetric soft tissue changes, esthetic outcomes, and patient-reported measures of pain and satisfaction will be evaluated during follow-up. The study aims to determine whether microneedling with i-PRF can provide comparable soft tissue augmentation while reducing patient morbidity associated with connective tissue graft harvesting.",[79],"Thin Peri-implant Mucosal Phenotype",[81,82,83,84,85,86,9],"Microneedling","Injectable Platelet-Rich Fibrin","i-PRF","Peri-implant soft tissue augmentation","Implant Esthetics","Mucosal Thickness","NOT_YET_RECRUITING","2026-06-19",{"date":90,"type":91},"2026-06-25","ACTUAL",{"date":93,"type":73},"2026-06-26",{"date":95,"type":73},"2027-03-26",{"name":5,"class":6},1]