[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100620692":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":10,"centralContacts":20,"locations":29,"responsibleParty":42,"collaborators":10,"id":46,"slug":47,"hasResults":48,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":48,"sex":54,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":10,"studyType":60,"phases":10,"briefSummary":61,"conditions":62,"keywords":65,"overallStatus":32,"whyStopped":10,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":79},{"fullName":5,"class":6},"Institute for Clinical and Experimental Medicine","OTHER_GOV",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"patients with advanced heart failure",null,"A group of patients with advanced heart failure were indicated for heart transplanta-tion for either ischemic or dilatational cardiomyopathy. The study group will also in-clude subjects with previously implanted LVAD as a bridge-to-transplant approach. Predictory-related subgroups will be evaluated separately.",[13],"Procedure: Heart transplantation for the final stage of heart failure",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":10},"PROCEDURE","Heart transplantation for the final stage of heart failure","The study population comprises patients who underwent heart transplantation for heart failure at the Institute for Clinical and Experimental Medicine, Cardiovascular Surgery Department, between June 2023 and December 2028. Only the subjects' retrospective clinical data and matching heart samples will be analyzed.",[9],[21,26],{"name":22,"role":23,"phone":24,"phoneExt":10,"email":25},"Ivana K Lesna, MD, PhD., assoc. prof.","CONTACT","00420236055445","ivana.kralova.lesna@ikem.cz",{"name":27,"role":23,"phone":10,"phoneExt":10,"email":28},"Peter Ivak, M.D., PhD, assoc. prof.","peter.ivak@ikem.cz",[30],{"facility":31,"status":32,"city":33,"state":10,"zip":34,"country":35,"countryCode":10,"cosmosGeoPoint":36,"geoPoint":41,"contacts":10},"Centre of Experimental Medicine, Institute for Clinical and Experimental Medicine,","RECRUITING","Prague","14021","Czechia",{"type":37,"coordinates":38},"Point",[39,40],14.42076,50.08804,{"lat":40,"lon":39},{"type":43,"investigatorFullName":44,"investigatorTitle":45,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Ivana Kralova Lesna","Ivana Kralova Lesna, M.D., PhD., assoc. prof.","100620692","pericoronary-adipocyte-size-gradient-100620692",false,"NCT07360925","Pericoronary Adipocyte Size Gradient","Direct Measurement of Pericoronary Adipocyte Size Gradient as a Parameter of Immunometabolic Changes of Perivascular Adipose Tissue","AdipoCor","Inclusion Criteria:\n\n* Age 30-90 years\n* Diagnosis of dilatational or ischemic cardiomyopathy\n* Patients undergoing heart transplantation in IKEM\n\nExclusion Criteria:\n\n* Known combined diagnosis of dilatational and ischemic cardiomyopathy\n* Arrhythmogenic cardiomyopathy\n* Congenital heart defects\n* Non-eligibility due to the absence of informed consent","ALL","30 Years","90 Years",{"count":58,"type":59},60,"ESTIMATED","OBSERVATIONAL","Evaluation of pericoronary adipocyte gradient (PCAT) in relationship with local atherosclerotic changes in a patient undergoing heart transplantation.",[63,64],"Heart Failure","Heart Transplantation",[66,67,68,69],"Pericoronary adipose tissue","adipocyte size","inflammatory changes","macrophages","2026-01-14",{"date":72,"type":73},"2026-01-22","ACTUAL",{"date":75,"type":73},"2023-06-01",{"date":77,"type":59},"2029-07-01",{"name":5,"class":6},1]