[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100556257":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":25,"locations":31,"responsibleParty":50,"collaborators":19,"id":52,"slug":53,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":54,"sex":60,"minAge":61,"maxAge":62,"enrollmentInfo":63,"targetDuration":19,"studyType":66,"phases":67,"briefSummary":69,"conditions":70,"keywords":73,"overallStatus":34,"whyStopped":19,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"University of Luxembourg","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"20 participants. Long covid patients.","EXPERIMENTAL","All patients will undergo a caloric restriction diet for a week.This begins with the intake of a laxative fluid on the first fasting day. This fluid aids in bowel emptying, akin to preparations for a colonoscopy. Detailed instructions on how to use it will be provided along with the laxative, and the study physician or dietary team will discuss dosage and intake with you. The caloric restriction period will last for 7 days and then be broken with the consumption of an apple. Following the breaking of the fast, three build-up days will follow to gradually increase food intake.",[13],"Other: 7-day ambulatory caloric restriction intervention using the Buchinger-Wilhelmi method",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":19},"7-day ambulatory caloric restriction intervention using the Buchinger-Wilhelmi method","Buchinger-Wilhelmi method, will be administered in an ambulatory setting under physician guidance. It involves an initial bowel cleanse followed by 7-day fasting period. The initial bowel cleanse will be performed according to the standard procedure commonly used for colonoscopy preparation. During the fasting period, subjects will be provided with a dietary energy supply of a maximum of 350 kcal per day, primarily consisting of vegetable broths as well as fresh vegetable juices. Patients will only be allowed to consume calorie-free and unsweetened water or tea in addition to the prescribed diet.",[9],null,[21],{"name":22,"affiliation":23,"role":24},"Raquel Gomez Bravo, PhD","Rehaklinik du Centre Hospitalier Neuro-Psychiatrique (CHNP), UL","PRINCIPAL_INVESTIGATOR",[26],{"name":27,"role":28,"phone":29,"phoneExt":19,"email":30},"Marta Sanchez, PhD","CONTACT","+3524666446555","marta.sanchez@uni.lu",[32],{"facility":33,"status":34,"city":35,"state":19,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"Rehaklinik CHNP","RECRUITING","Ettelbruck","L-9012","Luxembourg","LU",{"type":40,"coordinates":41},"Point",[42,43],6.10417,49.8475,{"lat":43,"lon":42},[46],{"name":47,"role":28,"phone":19,"phoneExt":48,"email":49},"Raquel Gómez-Bravo Gómez-Bravo, MD PhD","+352 26 82 37","raquel.gomezbravo@chnp.lu",{"type":51,"investigatorFullName":19,"investigatorTitle":19,"investigatorAffiliation":19,"oldNameTitle":19,"oldOrganization":19},"SPONSOR","100556257","periodic-fasting-for-treatment-of-long-covid-in-adults-a-pilot-study-100556257",false,"NCT06522750","Periodic Fasting for Treatment of Long Covid in Adults: a Pilot Study","Pilot Study on the Feasibility of an RCT: Evaluating Periodic Fasting as a Treatment Strategy for Long Covid in Adults","FASTCOV-P","Inclusion Criteria:\n\n* Age 18-64\n* Diagnosis Long Covid Syndrome (post-acute COVID-19 symptoms persisting ≥12 weeks)\n* Normal body Mass Index (18.5 to 25 kg\u002Fm2)\n* Marginal Iron status ( PF\\\u003C 25 ng\u002Fml)\n* Able to communicate in and comprehend English and\u002For German and\u002For French language\n* Present written \u002F signed declaration of consent\n* Ability to understand the patient information and willingness to sign the consent form\n* Consent to specimen collection and specimen use\n\nExclusion Criteria:\n\n* Current underweight condition (body mass index less than 18.5 kg\u002Fm2) or weight loss exceeding 3 kg within the last month or 5 kg within the last three months.\n* Existing \u002F current eating disorder within the past five years (e.g., anorexia, bulimia).\n* Psychiatric condition that limits understanding of the examination protocol (unable to consent)\n* Severe internal disease (e.g. kidney deficiency with creatinine \\> 2mg\u002Fdl), chronic inflammatory illness other than LCS\n* Participation in another intervention study.\n* Existing vegan diet or fasting during the last six months\n* Pregnancy or breastfeeding status.\n* Presence or suspicion of pre-existing ME\u002FCFS or early autonomous dysfunction\n* Diagnosis of chronic inflammatory bowel diseases, celiac disease or colorectal cancer according to the guidelines of the German Society of Gastroenterology\n* Use of anti-psychotic drugs\n* Antibiotic use during the previous 12 months\n* Start of novel drug therapy\n* Contraindication for additional blood draws (e.g. hemoglobin \\\u003C10)","ALL","18 Years","64 Years",{"count":64,"type":65},20,"ESTIMATED","INTERVENTIONAL",[68],"NA","Background:\n\nLong COVID, characterized by persistent symptoms following acute COVID-19 infection, has emerged as a significant public health concern. Symptoms range from fatigue, cognitive impairments, to respiratory difficulties, affecting patients\\' quality of life. Dietary interventions, particularly fasting, have historically been used to modulate immune responses and improve health outcomes in various conditions. The Buchinger-Wilhelmi method represents a structured and medically supervised fasting approach. Given the inflammatory nature of long COVID, fasting may offer therapeutic benefits by modulating the immune response, enhancing cellular repair mechanisms, and resetting metabolic processes.\n\nObjectives:\n\nThis clinical trial aims to assess the feasibility of a 7-day ambulatory fasting intervention using the Buchinger-Wilhelmi method on long COVID patients as primary objective. As secondary objectives, the study will investigate the potential beneficial impact of fasting on clinical, biological, and psychological parameters over a period of 4 weeks, offering insights into potential therapeutic avenues for long COVID management.\n\nStudy timeline:\n\nThe research will span a period of 4 weeks\n\nStudy population:\n\nThis study aims to recruit around 20 participants, who will all receive a fasting intervention using the Buchinger-Wilhelmi method.\n\nBiological sample and data collection:\n\nParticipants will undergo various data and sample collection procedures, including blood draws of up to 90 42 ml per visit, collection of peripheral mononuclear cells, stool samples, and completion of questionnaires in a smartphone-based Application (MyCap).\n\nSample analysis:\n\nThe collected samples will be subjected to a range of analyses, including the assessment of serological markers for routine blood chemistry, evaluation of inflammation markers, and examination of stool samples.",[71,72],"Long Covid","Chronic Inflammation",[74,75,76,77,78,79,80],"long covid","fasting","caloric restriction","chronic inflammation","dysbiosis","mitochondrial dysfunction","thrombosis","2025-03-25",{"date":83,"type":84},"2025-03-30","ACTUAL",{"date":86,"type":84},"2025-02-19",{"date":88,"type":65},"2025-09-30",{"name":5,"class":6},1]